Tyrosinase Inhibition Activity and Antioxidant Capacity by Fermented Products of Some Medicinal Plants

Abstract

The effects of fermented products from 40 medicinal herbals commonly available in Korea were examined according to concentrations of polyphenolic compound and kojic acid, and the activities of DPPH (α,α'-diphenyl-β-picrylhydrazyl) free radical scavenging and tyrosinase. The polyphenolic compound concentrations were 0.24 by Corydalis turtschaminovill ~ 11.42% (dry matter basis) by Syringa velutina in the extracts and 0.18 by Poria cocos ~ 12.27% by S. velutina in the fermented products. Kojic acid concentrations were 0.02 by Poria cocos Sclerotium ~ 9.67 mM by S. velutina in the extracts and 0.33 by P. cocos ~ 10.32 mM by S. velutina in the fermented products. Syringa velutina contained the highest polyphenolic compound and kojic acid concentrations, which were higher in the fermented product than in the extract. Higher DPPH free radical scavenging activity (>60%) was observed in the extracts of A. sessiliflorum, Citrus nobillis, and Angelica gigas and the fermented product of A. sessiliflorum compared to the other medicinal plants. Higher tyrosinase inhibition activity (>50%) was observed in the extracts of Morus alba, Glycyrrhiza glabra, and Rubus coreanus and the fermented products of G. glabra, Cnidium officinale, and S. velutina. Based on the above results, G. glabra, C. officinale, and S. velutina possessed high tyrosinase-inhibitive activities and kojic acid concentrations, which could be definitely enhanced by the fermentation of Phenillus linteus mycelium. 있다[3,14,19,20,24]. 한방 생약재에 관한 문헌을 근거로 한 tyrosinase 활성 저해효과는 메탄올 추출물인 갈근 25%, 후박 3%, 에탄올 추출물인 창출 14%, 갈근 10% 및 수용성 추출물인 상백피 63%, 감초 13-52%, 작약 44%, 당귀 39%, 천궁 28%, 복령 4%, 맥문동 0%로 비교적 낮은 저해 활성을 나타내었다[13]. 한편, 미백 화장품 개발 소재로 이용되고 있는 약용식물