Tyrosinase inhibition by extracts and constituents of stembark of Sideroxylon inerme L

Momtaz, Saeideh; Mapunya, B.; Houghton, Peter J.; Edgerly, Christina K.; Hussein, Ahmed A.; Naidoo, Sanushka; Lall, Namrita

doi:10.1055/s-0028-1083996

Cited by 2 publications

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“…The result for zone of inhibition of plant extract against test organisms showed that it was significantly active. Any activity above 12 mm is taken as a strong activity, although the percentage extracted was low when compared to other reported MAE (Momtaz et al, 2008). Extracts showed a very competitive activity when compared with ciprofloxacin.…”

Section: Results and Resultsmentioning

confidence: 93%

Microwave assisted extraction, phytochemical and antimicrobial evaluation of ethyl acetate extracts of stem bark of Ficus exasperata (Vahl)

Ugbenyo¹,

Anyam²,

Yahaya³

et al. 2021

jasem

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Stem bark of Ficus exasperata was extracted using ethyl acetate by microwave-assisted solvent extraction. Phytochemical screening and antimicrobial evaluation were carried out on the extract. Phytochemical screening revealed the presence of cardiac glycosides, tannins, flavonoids, triterpenes and steroids. Antimicrobial evaluation revealed that the extract is active against Methicillin – resistant Staphylococcus aureus (MRSA), Staphylococcus aureus, Streptococcus pneumoniae, Salmonella typhi, Proteus mirabilis, Shigella dysenteriae, Candida stellatoidea and Candida tropicalis. The zones of inhibition (mm) for the test organisms were (24 - 31) mm. Minimum inhibition concentrations (mg/L) of extract against MRSA, Staphylococcus aureus, Streptococcus pneumonia, Salmonella typhi, Proteus mirabilis, Shigella dysenteriae, Candida stellatoidea and Candida tropicalis were 2.5, 1.25,1.25, 2.5, 1.25, 1.25, 1.25 and 2.5 respectively. Minimum bactericidal concentrations (mg/L) of extract against Methicillin – resistant Staphylococcus aureus (MRSA), Staphylococcus aureus, Streptococcus pneumonia, Salmonella typhi, Proteus mirabilis Shigella dysenteriae Candida stellatoidea and Candida tropicalis were 5, 2.5, 2.5, 5, 5, 2.5,2.5 and 5 respectively. The extract showed high inhibition against MRSA and Candida tropicalis.

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Section: Results and Resultsmentioning

confidence: 93%

Microwave assisted extraction, phytochemical and antimicrobial evaluation of ethyl acetate extracts of stem bark of Ficus exasperata (Vahl)

Ugbenyo¹,

Anyam²,

Yahaya³

et al. 2021

jasem

View full text Add to dashboard Cite

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Antibiotic and novel compounds manipulation in vitro collagen matrix cells changes extracellular matrix non-complete cell division of fibroblast cells as new dermology technology

Ahmed

2021

Preprint

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Fibroblasts are several cells that are essential for human skin function and regulation process, the underfeed cells are a further issue of skin disorder the current study was based on isolated novel antibiotics compounds comparison of (Chloramphenicol IV) with the changes of Extracellular matrix (RC), inflammatory cells (SC) and non-complete cell division (ICD) effects on fibroblasts cell changes with the cell wall in structural and morphological changes. The new antibiotic compounds were measured and characters in (FTIR) methods with their functional group's analysis of bioactive compounds from Adhatoda vasica and Calotropis procera plants and their effective inhibition concentrations (I C50) extract's against tyrosinase conditions with their activity in vitro enzymatic process, both extracts have higher enzymatic inhibition assay was assessed. The fibroblast cells were compared with Chloramphenicol IV antibiotics with extracted compounds the cell wall was indiscretion and complete shape and structural changes were measured. The higher values of Diphenolase (22.5 μg/mL) was noted in Adhatoda vasica while an IC50 value of Monophenolase was 19.16 μg/mL, which is helpful in the treatment of fibroblast cell disorders, were higher in collagenase inhibition assay, elastase inhibition assay, hyaluronidase inhibition assay, tyrosinase inhibition assay process. It was concluded that novel antibiotics compounds from species could act an as effective role in fibroblast were used in future medicines as sources of locations and creams to control various skin diseases and skin disorder management's processes.

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Tyrosinase inhibition by extracts and constituents of stembark of Sideroxylon inerme L

Cited by 2 publications

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Microwave assisted extraction, phytochemical and antimicrobial evaluation of ethyl acetate extracts of stem bark of Ficus exasperata (Vahl)

Microwave assisted extraction, phytochemical and antimicrobial evaluation of ethyl acetate extracts of stem bark of Ficus exasperata (Vahl)

Antibiotic and novel compounds manipulation in vitro collagen matrix cells changes extracellular matrix non-complete cell division of fibroblast cells as new dermology technology

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