Tyrosine Crystals in Bone-Marrow

Jaiswal, Riddhi; Bhai, I; Nath, Navneet

doi:10.1016/s0140-6736(68)91959-4

Cited by 4 publications

(2 citation statements)

References 4 publications

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“…Thus the proteolytic process that we employed to obtain the crystals may parallel natural processes that occur in some living tissues. The tyrosine crystals have not, however, been found exclusively in tumors of these glands but have also been reported as occurring with myelogenous leukemia, 38 in the bone marrow, 39 sweat glands, 40 and in fibrous meningioma, a brain tumor. 41 The tyrosine crystals that we describe, which appear to be the same as those found in tissues and natural products, are in general not the same as any of the several crystal forms normally obtained by conventional laboratory crystallization techniques.…”

Section: ■ Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Tyrosine Microcrystals Produced by Digestion of Proteins with Pancreatic Enzymes

McPherson

Larson

Kuznetsov

2012

Crystal Growth & Design

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If serum albumin from several animals, including humans, at concentrations greater than about 60 mg/mL is combined with an aqueous extract of porcine or human pancreas, then massive amounts of microcrystals develop. Both raw blood serum, as well as a range of concentrated, pure proteins, when combined with the extract produced identical crystals. Morphologies of crystals and their aggregates did, however, show some dependence on the starting protein material. Crystals could be dissolved by boiling in water and recrystallized. By X-ray diffraction we showed the crystals to be l-tyrosine crystals, presumably a degradation product of the starting proteins. Amino acid analysis, supported by mass spectrometry, of even well washed crystals, however, consistently showed them to be composed of 20% to 30% of other amino acids. An atomic force microscopy investigation of the crystals revealed that the crystal surfaces were persistently coated with spherical particles about 3 nm in diameter. The particles are apparently micellar arrangements of oligopeptides. Some implications of our results with regard the appearance of tyrosine crystals in human tissues under pathological conditions, in tumors, and in natural products such as foods are discussed.

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Section: ■ Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Tyrosine Microcrystals Produced by Digestion of Proteins with Pancreatic Enzymes

McPherson

Larson

Kuznetsov

2012

Crystal Growth & Design

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Diagnosis of Metabolic Disease

Snyderman

1971

Pediatric Clinics of North America

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A Neuropathological Investigation of a Case of Tyrosinosis

Kobayashi

Nakamuea

Akai

1980

Acta Pathologica Japonica

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An autopsy case of tyrosinosis was reported. The patient was a 5‐month‐old boy who had jaundice and hepatosplenomegaly since 10 weeks after his birth. Tyrosine blood level was 6.937 mg/dl and the level of p‐HPPA oxidase low. Neuropathologically, the cerebral lesions were characterized by a spongy state, vacuoles in neuronal cells and focal deposition of PAS‐positive substance in and around the axon. The electron microscopic examination revealed axonal degeneration and unusual deep cortical structure, possibly axons, containing numerous lysosomes, elongated mitochondria and MCB‐like bodies in unmyelinated axon. These facts were suggested to represent morphologic evidence of altered cellular metabolism, related to impaired tyrosine degradation.

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Tyrosine Crystals in Bone-Marrow

Cited by 4 publications

References 4 publications

Tyrosine Microcrystals Produced by Digestion of Proteins with Pancreatic Enzymes

Tyrosine Microcrystals Produced by Digestion of Proteins with Pancreatic Enzymes

Diagnosis of Metabolic Disease

A Neuropathological Investigation of a Case of Tyrosinosis

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