Tyrosine pretreatment reverses hypothermia-induced behavioral depression

Rauch, Terry M.; Lieberman, Harris R.

doi:10.1016/0361-9230(90)90299-f

Cited by 52 publications

(32 citation statements)

References 12 publications

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“…Rats immersed in cold water (17°C) were also reported to be more behaviorally depressed than controls (Rauch and Lieberman 1980). Analogous patterns of cognitive impairment and adverse mood changes have been reported in humans.…”

Section: Discussionmentioning

confidence: 77%

Chronic intermittent cold stress and serotonin depletion induce deficits of reversal learning in an attentional set-shifting test in rats

et al. 2008

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Rationale-Chronic stress perturbs modulatory brain neurotransmitter systems, including serotonin (5-HT), and is a risk factor for psychiatric disorders such as depression. Deficits in cognitive flexibility, reflecting prefrontal cortical dysfunction, are prominent in such disorders. Orbitofrontal cortex (OFC) has been implicated specifically in reversal learning, a form of cognitive flexibility modulated by 5-HT.Objectives-Assess the effects of chronic intermittent cold (CIC) stress, a potent metabolic stressor, on performance of rats in an attentional set shifting test (AST). Assess a possible role for serotonin in CIC-induced deficits, and test the effects of acute serotonin reuptake blockade. Methods-MaleSprague-Dawley rats were exposed to CIC stress (14 days × 6 hr/day at 4 °C) before testing on the AST. In subsequent experiments, brain 5-HT was depleted in naïve rats with para-chlorophenylalanine, or 5-HT release was increased acutely in CIC-stressed rats with citalopram (5 mg/kg, s.c.) given 30 min prior to the first reversal task. Microdialysis was used to assess CICinduced changes in 5-HT release in OFC during testing.Results-CIC-stressed rats exhibited a selective impairment on the first reversal task in the AST. 5-HT depletion induced a similarly selective deficit in reversal learning. The CIC-induced impairment in reversal learning was attenuated by acute 5-HT reuptake blockade. 5-HT release was reduced in OFC of CIC-stressed rats during behavioral testing.Conclusions-The CIC stress-induced impairment of cognitive flexibility may involve dysregulation of 5-HT modulatory function in OFC. Such deficits may thus model relevant symptoms of neuropsychiatric disorders that respond positively to SSRI treatment.

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Section: Discussionmentioning

confidence: 77%

Chronic intermittent cold stress and serotonin depletion induce deficits of reversal learning in an attentional set-shifting test in rats

et al. 2008

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“…as a correct response, and was followed by the delivery of a food Rauch and Lieberman (1990) also showed that rats adpellet. A response to the previously non-cued lever extinguished ministered tyrosine prior to cold water (17°C) immersion both cue lights and was recorded as an incorrect response.…”

Section: Camentioning

confidence: 91%

“…Furtherm ore, these data are congruous w ith preparisons showed that cold exposure following saline advious research attesting to the beneficial effects of tyministration significantly increased the slope of cumularosine on a variety of behavioral and cognitive measures five errors relative to the 22*C saline condition during, or following, exposure to other acute stressors (p..0.0001). During cold sessions, the slope characteriz- (Reinstein et al 1984;Banderet and Lieberman 1989: jig cumulative error rate following 50 mg/kg tyrosine did Rauch and Lieberman 1990;Ahlers et al 1992). Howevnot significantly differ from saline (P>0.05), while the er, although tyrosine administration ameliorated the efslopes characterizing cumulative errors for 100 and 200 fact of cold stress on DMTS performance, it did not com-,,,/kg tyrosine were significantly lower, relative to saline pletely reverse the effect of cold, and performance levels (bth PS=0.0001).…”

Section: Camentioning

confidence: 99%

Tyrosine ameliorates a cold-induced delayed matching-to-sample performance decrement in rats

et al. 1993

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“…Human and animal studies have also found that tyrosine, a nutrient precursor of catecholamines, appears to enhance catecholaminergic function and prevent cold-induced decrements in mood and cognitive performance (22)(23)(24). Gibson and Wurtman (22) demonstrated that tyrosine can increase the rate at which norepinephrine (NE) is synthesized in the CNS of rats during acute ambient cold exposure (4°C) relative to rats not administered tyrosine and exposed to cold.…”

Section: Introductionmentioning

confidence: 99%

Psychoneuroendocrine effects of combined thyroxine and triiodothyronine versus tyrosine during prolonged Antarctic residence

Palinkas

Reedy

Smith

et al. 2007

International Journal of Circumpolar Health

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Objectives. We previously reported that cognitive function improves with thyroxine and that there is a circannual pattern to mood and human TSH during Antarctic residence. To extend these findings, we examined the effects of tyrosine and a combined levothyroxine/ liothyronine supplement in euthyroid men and women who spent the austral summer (n=43) and/or winter (n=42) in Antarctica. Study Design. Randomized, placebo-controlled, clinical trial. Methods. Subjects were randomized to receive the following each day for 91.6±3.2 days in summer and/or 138.0± 3.2 days in winter: (1) 12g tyrosine mixed in 113g applesauce; (2) 50ug of levothyroxine and 12.5ug of liothyronine (T4-T3 Supplement); or (3) placebo. Cognitive performance and mood were assessed using the Automatic Neuropsychological Assessment Metric -Isolated and Confined Environments. Effectiveness of thyroid supplement and tyrosine in Antarctica Results. With placebo in summer, mood did not change while TSH decreased by 28%; in winter, there was a 136% degradation in mood (p<0.01) and TSH increased by 18%. With combined T4-T3 supplement, there was a 51% degradation in mood in summer compared with placebo (p<0.05) and TSH decreased by 57%; in winter there was a 135% degradation in mood while TSH was reduced by 26% (p<0.05). Tyrosine use in summer was associated with no change in mood and a 30% decline in TSH, while in winter there was a 47% improvement in mood and TSH decreased by 28% along with a 6% increase in fT3 (p<0.05). Conclusions. Administration of tyrosine leads to a significant reduction in serum TSH and improvement in mood in winter compared with placebo, while the combined T4-T3 supplement leads to a worsening of mood in summer and no improvement in winter. There appears to be a seasonal influence on the psychological response to interventions and the relationship to changes in TSH reductions. (Int J Circumpolar Health 2007; 66(5):401-417)

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Tyrosine pretreatment reverses hypothermia-induced behavioral depression

Cited by 52 publications

References 12 publications

Chronic intermittent cold stress and serotonin depletion induce deficits of reversal learning in an attentional set-shifting test in rats

Chronic intermittent cold stress and serotonin depletion induce deficits of reversal learning in an attentional set-shifting test in rats

Tyrosine ameliorates a cold-induced delayed matching-to-sample performance decrement in rats

Psychoneuroendocrine effects of combined thyroxine and triiodothyronine versus tyrosine during prolonged Antarctic residence

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