U.S. domestic cats as sentinels for perfluoroalkyl substances: Possible linkages with housing, obesity, and disease

Bost, Phillip C.; Strynar, Mark J.; Reiner, Jessica L.; Zweigenbaum, Jerry; Secoura, Patricia L.; Lindstrom, Andrew B.; Dye, Janice A.

doi:10.1016/j.envres.2016.07.027

Cited by 32 publications

(40 citation statements)

References 64 publications

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“…This observation is in agreement with a recent study, where PFOA levels in cats’ serum ( n = 72) were grouped into 4 quartiles, and significant association were observed between hyperthyroidism ( n = 4) and the fourth quartile 4. However, the age of the cats was not controlled ranging from 0.5 to 19 yr old (Bost et al ). Furthermore, from a toxicological perspective, a previous study suggested significant decrease ( p < 0.05) in total T4, free T4, and total T3 following oral PFOA dosage in rats over a 5‐d period, and the hormonal changes were associated with PFOA through the peroxisome proliferator‐activated receptor agonism (Martin et al ).…”

Section: Resultsmentioning

confidence: 99%

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Per‐ and polyfluoroalkyl substances in Northern California cats: Temporal comparison and a possible link to cat hyperthyroidism

Wang

Guo

Gardner³

et al. 2018

Enviro Toxic and Chemistry

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The indoor environment and dietary intake are considered to be major human exposure pathways to per- and polyfluoroalkyl substances (PFASs). Cats have similar exposures to humans by sharing their residential environments, although they have different diet, body sizes, and indoor activities. In the present study, we report PFAS levels in the serum of 2 groups of Northern California cats (>10 yr old) collected during 2 time periods: 2008 to 2010 (n = 21) and 2012 to 2013 (n = 22). Levels of ∑PFAS (geometric mean) were lower in the second period (geometric mean = 8.10 ng/mL) than the first time period (geometric mean = 15.8 ng/mL), although PFAS profiles remained similar. We also analyzed PFAS levels in human serum collected in the same time period (2008-2010) and geographic area, and compared the profiles and ∑PFAS levels (15.8 vs 14.3 ng/mL for cat and human, respectively). Long chain perfluorinated carboxylic acids, especially perfluorononanoic acid and perfluoroundecanoic acid, were significantly higher in cat serum than in humans. Furthermore, serum from hyperthyroid cats in the second time period showed higher ∑PFAS level (9.50 ng/mL) compared to nonhyperthyroid cats (7.24 ng/mL), and it is the perfluorooctanoic acid levels that were statistically significantly higher in hyperthyroid cats' serum (p < 0.05). This result may indicate a possible link between PFAS levels and cat hyperthyroid, warranting a larger study for further investigation. Environ Toxicol Chem 2018;37:2523-2529. © 2018 SETAC.

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Section: Resultsmentioning

confidence: 99%

“…We recently reported a possible causative link between high PBDE levels and hyperthyroid status in cats from Northern California (Guo et al , ). In addition, a recent study suggested possible linkages between thyroid disease and serum PFOA levels in indoor cats (Bost et al ).…”

Section: Resultsmentioning

confidence: 99%

Per‐ and polyfluoroalkyl substances in Northern California cats: Temporal comparison and a possible link to cat hyperthyroidism

Wang

Guo

Gardner³

et al. 2018

Enviro Toxic and Chemistry

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“…Epidemiological studies also suggested that kidney function may be associated with the blood levels of PFAAs [28]. As reported previously, higher levels of PFAAs in serum were linked with chronic kidney disease in domestic cats [29]. Hence, we analyzed twelve genes that were known to be associated with kidney function and injury.…”

Section: Discussionmentioning

confidence: 87%

Changes in hepato-renal gene expression in microminipigs following a single exposure to a mixture of perfluoroalkyl acids

Sakuma

Ochi²,

Yoshioka

et al. 2019

PLoS ONE

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It is evident that some perfluoroalkyl acids (PFAAs), a group of globally dispersed pollutants, have long biological half-lives in humans and farm animals. However, the effects of PFAAs in domestic animals have not been fully elucidated. The present study investigated how exposure to a single dose of a mixture of 10 PFAAs influenced hepatic and renal gene expression and histopathology, as well as plasma clinical biochemistry, in microminipigs (MMPigs) over 21 days. In animals treated with PFAAs, the mRNA expression of twelve genes related to fatty acid metabolism was upregulated in the kidney, while only few of these genes were induced in the liver. The expression of several kidney injury-associated genes such as, IGFBP1, IGFBP6, GCLC X2, GCLC X3, MSGT1, OLR1 was upregulated in the kidney. Interestingly, the expression of IGFBP-genes was differentially altered in the liver and kidney. Our findings thus identified hepato-renal gene expression changes in MMPigs that were associated with various molecular pathways including peroxisome proliferation, lipid metabolism, kidney injury, and apoptosis. Furthermore, serum HDL levels were significantly decreased following exposure to PFAAs, whereas no significant histopathological changes were detected, as compared to the vehicle group. Taken together, the present study provided the first indication that a single exposure to a mixture of PFAAs can produce changes in MMPig renal gene expression that were observed three weeks post exposure, suggesting that more attention should be paid to the kidney as a primary target organ of PFAAs.

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“…[47]. Cats from the US [21, 48] had 2–4 times higher serum levels than cats from Sweden [49]. The US study could show that serum from hyperthyroid cats showed higher PFAS level (9.50 ng/mL) compared to nonhyperthyroid cats (7.24 ng/mL), due to the levels of perfluorooctanoic acid (PFOA, P < 0.05).…”

Section: Endocrine Disrupting Chemicals In Catsmentioning

confidence: 99%

Are persistent organic pollutants important in the etiology of feline hyperthyroidism? A review

2019

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Feline hyperthyroidism is a rather new disease, first reported from the North American east coast in 1979. The prevalence is increasing, especially in older cats, and hyperthyroidism is now reported worldwide as the most common feline endocrinopathy. Several studies have been performed trying to identify important etiological factors such as exposure to persistent organic pollutants, and especially brominated flame retardants, have been suggested to be of importance for the development of the disease. Recent studies have shown higher concentrations of these contaminants in serum of hyperthyroid cats in comparison to cats with normal thyroid status. However, other still unknown factors are most probably of importance for the development of this disease.

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U.S. domestic cats as sentinels for perfluoroalkyl substances: Possible linkages with housing, obesity, and disease

Cited by 32 publications

References 64 publications

Per‐ and polyfluoroalkyl substances in Northern California cats: Temporal comparison and a possible link to cat hyperthyroidism

Per‐ and polyfluoroalkyl substances in Northern California cats: Temporal comparison and a possible link to cat hyperthyroidism

Changes in hepato-renal gene expression in microminipigs following a single exposure to a mixture of perfluoroalkyl acids

Are persistent organic pollutants important in the etiology of feline hyperthyroidism? A review

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