Abstract-In this paper, a U-shaped microstrip patch antenna with meandered slots is presented. It is designed for biomedical applications to operate at 2.45 GHz. Based on the simulation experience, two designs of the patch are introduced with and without use of meandered slots. The comparative study between these two is also demonstrated. It is observed that the antenna with meandered slots shows good performance with sufficient bandwidth, low losses and is capable of use in biomedical applications. Furthermore, the proposed antenna has small size of 35 * 29 * 1.6 mm 3 , and the size of the ground is only 14% of the overall antenna size. The measured and simulated results show good agreement with each other. The antenna is fabricated on an FR4 substrate, and simulation is carried out on FDTD based Empire XCcel simulator.