The advance of technology has enabled the development of unmanned systems/vehicles used in the air, on the ground or on/in the water. The application range for these systems is continuously increasing, and unmanned platforms continue to be the subject of numerous studies and research contributions. This paper deals with the role of sensors and measurements in ensuring that unmanned systems work properly, meet the requirements of the target application, provide and increase their navigation capabilities, and suitably monitor and gain information on several physical quantities in the environment around them. Unmanned system types and the critical environmental factors affecting their performance are discussed. The measurements that these kinds of vehicles can carry out are presented and discussed, while also describing the most frequently used on-board sensor technologies, as well as their advantages and limitations. The paper provides some examples of sensor specifications related to some current applications, as well as describing the recent research contributions in the field.