Über Beziehungen zwischen Blutgerinnung und Kreislauffunktion

Fibrinolysis and peritoneal dialysis in the treatment of diabetic coma, complicated by severe shock. A case report

“…Since heparin therapy did not seem to have a favourable effect we decided to start a fibrinolytie therapy. To our knowledge, the case of Lasch et al [9] and ours were the only ones in which fibrinolysis has been performed over a prolonged period. It is remarkable that fibrinolysis did not show an effect on renal function in our patient.…”

“…vascular clotting and severe glomerular thrombosis was revealed by autopsy. The latter case is reminiscent of a diabetic patient mentioned by Lasch et al [9], that had been treated with fibrinolysis in the course of a severe shock due to diabetic coma.…”

“…Advances in the pathology of microcirculation [8,11] have led to a remarkable improvement in the therapy of severe shock. The importance of a heparin prophylaxis and of fibrinolysis in the treatment of persistent shock complicating diabetic coma has already been stressed by Lasch et al [9] and by Siebenmann and Reutter [19]. To our knowledge both heparin prophylaxis and fibrinolysis have not yet become part of the usual standard therapy [14] of diabetic ketoacidosis.…”

The effect of heparinized blood exchange transfusion on endotoxin induced disseminated intravascular coagulation (DIC)

“…Polymerisation of fibrin monomer is inhibited to a certain extent by complex formation with fibrinogen and fibrin degradation products [10,20] resulting in the so called soluble fibrin monomer complexes (SFMC). Furthermore, these fibrinogen fibrin intermediates äs well äs activated coagulation factors can not be removed from the circulation since the reticuloendothelial System is blocked [5,16] and the fibrinolytic activity impaired by endotoxin [l, 8]. Hence fibrin and fibrin complexes are deposited in the renal glomerular capillaries and other Organs [11, 21, 1 26] to form microclots.…”

The effect of venous congestion on the blood clotting system

“…Lasch, Mechelke, Nusser & Sessner (1958), studying priniarily the blood levels of prothrombin (factor 11) and proconvertin (factor VII), have maintained the view that there are certain connectioiis between the circulation rate and the blood levels of different clotting factors. Their hypothesis was founded on the theory of a latent continuous intravascular coagulation.…”