Über den Einfluss langjährigen Zigarettenrauchens auf die Lungenfunktion jugendlicher Normalpersonen

Hüttemann, U.; Oswald, P.; Lode, Holger N.; Huckauf, H.

doi:10.1159/000192897

Cited by 6 publications

(4 citation statements)

References 16 publications

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“…Smokers were expected to show a fall in compliance at increased respiratory rates (Ingram and O'Cain, 1971;Huttemann et al, 1972), but this finding was not confirmed in the larger number of subjects in this study. There was a slight excess of heavier smokers in the control group and six male volunteers were excluded from analysis for FDC because their FEV1 was less than 80% of predicted.…”

Section: Discussionmentioning

confidence: 66%

Frequency dependence of dynamic compliance in patients with rheumatoid arthritis.

Hills¹,

Davies²,

Geary³

1979

Thorax

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Section: Discussionmentioning

confidence: 66%

Frequency dependence of dynamic compliance in patients with rheumatoid arthritis.

Hills¹,

Davies²,

Geary³

1979

Thorax

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“…On the other hand, constituents of the tobacco present in the small airways [33] might bring about an alveolar underventilation with maintained perfusion owing to hypersecretion of mucus. However, even an appreciable increase in the airway resistance in the small airways is not reflected in the Raw [25], since the small airways only account for 10-30% of the overall airway resistance of the bronchial system [20,29,39,48]. We were unable to observe an alteration in the Cdyn40 after smoking as a possible indication for an increase in resistance in the small airways [20,39,48].…”

Section: Discussionmentioning

confidence: 68%

“…However, even an appreciable increase in the airway resistance in the small airways is not reflected in the Raw [25], since the small airways only account for 10-30% of the overall airway resistance of the bronchial system [20,29,39,48]. We were unable to observe an alteration in the Cdyn40 after smoking as a possible indication for an increase in resistance in the small airways [20,39,48]. The Cayn40 reacts congruently with the fall in Raw, but the rise was not statistically significant.…”

Section: Discussionmentioning

confidence: 99%

Acute ventilation-perfusion mismatching resulting from inhalative smoking of the first cigarette in the morning

Rieben

1992

Clin Investig

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The effect of the first cigarette in the morning on the airway resistance (R,w) which can be measured by body-plethysmography was investigated in 70 inhaling cigarette smokers. The test population showed a significant (P<0.0005) fall in R,w 8 rain after smoking. A further study (n = 16) showed that the fall in R~w was most likely to be attributable to a decrease in the trapped air. The effect of the first cigarette in the morning on the arterial blood gases and on the alveolar-arterial oxygen difference P(A-a)O2 and carbon dioxide difference P(A-a)CO2 was investigated in 12 inhaling cigarette smokers. Smoking gave rise to a significant (P < 0.0005) fall in the partial pressure of oxygen (PaO2) with compensatory overventilation. At the same time, the P(A-a)O2 and the P(A-a)CO2 increased significantly (P<0.01 and P<0.05, respectively). This effect could be observed for up to 24 min after smoking. In addition, the flow of blood in the pulmonary capillaries was measured in 28 test subjects with the nitrous oxide method ((~N2o) before, and 18-22 min after, smoking the first cigarette in the morning. After smoking, there was a significant (P < 0.0005) fall in the 0N2o by an average of 11.3%. The decrease in the Raw, the fall in the PaO2 with compensatory overventilation, the increase in P(A-a)O2 and P(A-a)CO2 and the decrease in the 0N2o are interpreted as manifestations of pronounced acute ventilation-perfusion mismatching induced by smoking.Abbreviations: Cdyn = dynamic compliance; Cdyn 40 = dynamic compliance at 40 breaths/min; QN~o =pulmonary capillary blood flow measured by the N/O method; P(A-a)= alveolararterial pressure difference; Pa=arterial partial pressure; APAo=alveolar pressure difference measured in the pressureflow curve at zero flow; Raw = airway resistance; sGaw = specific airway conductance; SVI=stroke volume index; TGV= thoracic gas volume; BSA = body surface area

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“…Dieser Mittel wert hegt deutlich niedriger als der von 20 Nichtrauchern, der von Hüttemann et al [15] mit 3,58 g • cm/ml angegeben wurde. Die von die sen Autoren gefundene Standardabweichung von ±1,11 g • cm/ml ent spricht recht gut der unsrigen.…”

Section: Diskussionunclassified

Normalwerte der ventilatorischen Atemarbeit

Börngen¹

1976

Respiration

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Ventilatory work of breathing is defined as a variable referring to the mechanics of the breathing function of the lung, ascertainable from the alveolar pressure-breathing volume diagram. Information on the resistance of the respiratory canal can be obtained. The ventilatory respiration of 93 healthy persons at spontaneous resting breath frequency (15 ± 3 min) was investigated, with the aid of a body plethysmograph. A mean value of 2.21 g·cm/ml (s = 0.92) was obtained. A dependence on age and sex could not be statistically proved. The value of 4.0 g•cm/ml (= 2 s) is discussed as a limit to a pathological increase. With a rise in breath volume, relative weight and also, marginally, the spontaneous resting breath frequency, a significant increase of ventilatory work of breathing in normal persons must be anticipated. A so-called index of ventilatory work of breathing (breath volume/alveolar pressure changes under defined conditions) correlates significantly with ventilatory work of breathing and can thus be regarded as an orientating value for the resistance of the respiratory canal. Its mean value amounts to 3.10 cm/cm, with a SD of 1.12.

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Über den Einfluss langjährigen Zigarettenrauchens auf die Lungenfunktion jugendlicher Normalpersonen

Cited by 6 publications

References 16 publications

Frequency dependence of dynamic compliance in patients with rheumatoid arthritis.

Frequency dependence of dynamic compliance in patients with rheumatoid arthritis.

Acute ventilation-perfusion mismatching resulting from inhalative smoking of the first cigarette in the morning

Normalwerte der ventilatorischen Atemarbeit

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