Über den Einfluß von Adenosin und Adenosinphosphorsäuren auf den isolierten Meerschweinchenuterus

Deuticke, H. J.

doi:10.1007/bf01752009

Cited by 36 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Extracellular effects of purines were also identified in non‐cardiovascular preparations, including adenosine‐ and ATP‐induced contraction of the uterus (Deuticke 1932, Watts 1953) and intestine (Gillespie 1934, Ewing et al. 1949, Mihich et al.…”

Section: Early Studies Of the Extracellular Effects Of Purinesmentioning

confidence: 99%

The birth and postnatal development of purinergic signalling

et al. 2010

View full text Add to dashboard Cite

The purinergic signalling system is one of the most ancient and arguably the most widespread intercellular signalling system in living tissues. In this review we present a detailed account of the early developments and current status of purinergic signalling. We summarize the current knowledge on purinoceptors, their distribution and role in signal transduction in various tissues in physiological and pathophysiological conditions.

show abstract

Section: Early Studies Of the Extracellular Effects Of Purinesmentioning

confidence: 99%

The birth and postnatal development of purinergic signalling

et al. 2010

View full text Add to dashboard Cite

show abstract

“…Adenosine and its compounds have been shown to be present in a large number of tissues. Some of their pharmacological effects have been studied by Drury and Szent-Gy6rgyi [1929], Bennet and Drury [1931], Zipf [1931], Ostern and Parnas [1932], Deuticke [1932] and Drury [1932]. Zipf has drawn attention to the fact that they are probably responsible for those effects of defibrinated blood which Freund [1920] attributed to the "Friihgift.…”

mentioning

confidence: 99%

The localization of the action of drugs on the pulmonary vessels of dogs and cats

Gaddum¹,

Holtz²

1933

The Journal of Physiology

View full text Add to dashboard Cite

SINCE previous studies of the effect of drugs on the pulmonary vessels have been reviewed by Wiggers [1921], Tigerstedt [1923] and Daly [1932], it is not necessary for us to present a connected historical survey.We will discuss earlier work only in so far as it bears directly on our own experiments, which were devised with the chief object of obtaining information regardingthe site of action on the pulmonary circulation of various pharmacologically active substances which are found in tissue extracts.In early work on this subject the assumption was usually made that any observed effects of drugs on the resistance of the pulmonary vessels to the flow of blood were due to an action on the pulmonary arterioles. The suggestion that changes in the tone of the pulmonary veins might appreciably affect the resistance originated partly from the study of the action of drugs on isolated veins [Inchley, 1923[Inchley, , 1926 Franklin, 1932, who gives other references], and partly from observations of the lung volume when the circulation was intact [Luisada, 1928;Mautner and Pick, 1929]. Mautner and Pick have shown that the blood flow through the portal system of the dog is much influenced by the resistance offered by the hepatic veins under the action of histamine, and they give evidence suggesting that histamine also causes the pulmonary veins to constrict.The conclusions of Mautner and Pick regarding the portal circulation have been confirmed and extended in an investigation carried out in this laboratory [Bauer, Dale, Poulsson and Richards, 1932]. The present work was undertaken with the object of applying similar methods to the study of the behaviour of the pulmonary vessels. It was hoped that fresh light might be thrown on the importance of the pulmonary veins by

show abstract

“…In isolated smooth muscle preparations in which there is tone, adenosine generally produces relaxation. One previously known exception is the guinea-pig uterus, in which it produces contraction (Deuticke 1932). Another is the partly contracted anococcygeus muscle, in which non-phosphorylated purines (such as adenosine and NECA) produce a further contraction (Stone 1983).…”

Section: Discussionmentioning

confidence: 99%

Pharmacological Actions of the Coenzymes Nad(h) and Nadp(h) on the Rat Anococcygeus Muscle

Najbar

Rand

1994

Clin Exp Pharma Physio

View full text Add to dashboard Cite

1. The pharmacological actions of the oxidized and reduced forms of nicotinamide-adenosine dinucleotide (NAD, NADH) and nicotinamide-adenosine dinucleotide phosphate (NADP, NADPH) were studied on rat isolated anococcygeus muscles. 2. The actions of the two nucleotides were different, but there were no apparent qualitative differences between the oxidized and reduced forms of each. 3. In fully relaxed anococcygeus muscles, NADP(H) produced transient contractions that were subject to desensitization, but NAD(H) had no effect. 4. NADP(H) slightly enhanced contractions elicited by noradrenergic nerve stimulation. In contrast, noradrenergic contractions were inhibited by NAD(H). NADH reduced the stimulation-induced release of noradrenaline, but enhanced contractions elicited by exogenous noradrenaline. 5. In anococcygeus muscles partly contracted with guanethidine, NAD(H) produced a further sustained increase in tone; in contrast, NADP(H) mainly produced transient relaxations to which there was immediate desensitization. 6. Relaxations of anococcygeus muscle elicited by nitrergic nerve stimulation were not affected by NAD. In contrast, NADP(H) reduced them. 7. The actions of NAD(H) were generally the same as those of adenosine and can be attributed to activation of P1-purinoceptors since they were blocked by the selective antagonist 8-sulphophenyltheophylline. 8. The actions of NADP resembled those of the P2-purinoceptor agonist ATP to some extent, but there were some differences. As suggested by others, NADP may act on a unique receptor.

show abstract

Über den Einfluß von Adenosin und Adenosinphosphorsäuren auf den isolierten Meerschweinchenuterus

Cited by 36 publications

References 0 publications

The birth and postnatal development of purinergic signalling

The birth and postnatal development of purinergic signalling

The localization of the action of drugs on the pulmonary vessels of dogs and cats

Pharmacological Actions of the Coenzymes Nad(h) and Nadp(h) on the Rat Anococcygeus Muscle

Contact Info

Product

Resources

About