Über den Einfluß von Substituenten auf die Ultraviolettabsorption zweier konjugierter Benzolchromophore

Pestemer, Max; Mayer-Pitsch, E.

doi:10.1007/bf01755659

Cited by 14 publications

(1 citation statement)

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“…Similar steric effects result when groups are ortho to the nitro group (40a, 209), causing a hindrance to the coplanarity of the oxygen atoms in such resonating structures as o-0-Remington found Xmax for p-nitro-lV, iV-dimethylaniline to diminish rapidly as one, and then two, methyl groups are placed ortho to the nitro group (see figure 10). Several investigators (58,113,232,235,257,276,286,301) have offered additional examples of steric hindrance occurring in the excited state of organic molecules, particularly the substituted biphenyls. It is found that 3,3'or 4,4'-disubstituted biphenyls have spectra similar to that of biphenyl with, perhaps, anticipated substitutive effects.…”

Section: Steric Hindrance and Colormentioning

confidence: 99%

Relationships between Absorption Spectra and Spectra and Chemical Constitution of Organic Molecules.

Ferguson¹

1948

Chem. Rev.

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Section: Steric Hindrance and Colormentioning

confidence: 99%

Relationships between Absorption Spectra and Spectra and Chemical Constitution of Organic Molecules.

Ferguson¹

1948

Chem. Rev.

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Syntheses and Selective Inhibitory Activities of Terphenyl‐Bisamidines for Serine Proteases

Saal¹,

Engh

Eichinger

et al. 1996

Archiv der Pharmazie

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Biphenyl nitriles 5a-c, terphenyl dinitriles 11a-d, and naphthalene-bis(benzonitrile) 11c were prepared by palladium-catalyzed cross coupling reactions and subsequently converted to biphenyl amidines 8a-c and bis(benzamidines) 4a-e. Among the biphenyl amidines 8 only the meta-derivative 8b inhibits factor Xa and trypsin (Ki = 10 microM). The terphenyl bisamidine 4c does not inhibit factor Xa, trypsin, thrombin, and plasmin, while 4a and 4d are almost equipotent inhibitors of these enzymes (Ki 1-6 microM), and 4b and 4e are selective for trypsin (Ki = 0.2 and 0.3 microM; but Ki > 1 microM for factor Xa, thrombin, and plasmin). X-ray analysis of crystals of 4b complexed with bovine trypsin revealed a unique binding mode: one benzamidino group binds in the S1 site to the side chain carboxylate of Arg189. The central phenyl group is twisted away from the S2/S3 sites and the second amidino group contacts the Asn143 side chain.

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Über den Einfluss von Substituenten auf die Ultraviolettabsorption des mit anderen Chromophoren konjugierten Benzolchromophors

Pestemer

1937

Zeitschrift für Elektrochemie und angewandte physikalische Chem

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Über den Einfluß von Substituenten auf die Ultraviolettabsorption zweier konjugierter Benzolchromophore

Cited by 14 publications

References 0 publications

Relationships between Absorption Spectra and Spectra and Chemical Constitution of Organic Molecules.

Relationships between Absorption Spectra and Spectra and Chemical Constitution of Organic Molecules.

Syntheses and Selective Inhibitory Activities of Terphenyl‐Bisamidines for Serine Proteases

Über den Einfluss von Substituenten auf die Ultraviolettabsorption des mit anderen Chromophoren konjugierten Benzolchromophors

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