Über die Bedeutung des NH3-Gehaltes des Blutes für die Beurteilung der Leberfunktion

Monguio, J; Krause, Fr.

doi:10.1007/bf01778447

Cited by 38 publications

(4 citation statements)

References 23 publications

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“…It has been shown that the blood ammonia in such dogs on a high protein diet may be increased. Further-more blood ammonia values after ammonia administration are higher in Eck fistula dogs than in normal controls (11). This indicates that the ability of the liver to form urea is subnormal in the Eck fistula dog.…”

Section: (From the Department Of Pathology The University Of Rochestmentioning

confidence: 71%

Liver Function and Blood Plasma Protein Formation

Knutti

Erickson

Madden

et al. 1937

Journal of Experimental Medicine

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Normal dogs and two Eck fistula dogs, receiving a daily diet containing an average of 1 gm. of vegetable protein per kilo of body weight, showed after average intervals of 7 to 9 weeks, slight decreases in amounts of circulating plasma protein (Table 21). A third Eck fistula dog under similar circumstances was unable to maintain its plasma protein concentration above the edema level. This dog by biopsy was shown to have an abnormal liver and the evidence indicated that the other organs were normal. The animal showed active thirst and diuresis as compared with controls (Table 25). This Eck fistula dog had less than one-tenth the capacity of the normal dog to form new plasma protein when various food proteins were added to the basal diet, and no significant quantitative differences in the relative potency of these foods (liver, kidney, heart muscle, soy bean, salmon) could be distinguished (Table 22). It appears that the liver abnormality is responsible for this abnormal reaction. This observation gives strong support to the thesis that the liver is actively concerned with fabrication of new plasma protein.

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Section: (From the Department Of Pathology The University Of Rochestmentioning

confidence: 71%

Liver Function and Blood Plasma Protein Formation

Knutti

Erickson

Madden

et al. 1937

Journal of Experimental Medicine

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“…Among them, ammonia is the most important in the treatment of hepatic encephalopathy in the sense that we can control it to some extent. In patients with portal-systemic shunt and experimental animals with hepatic damage or Eck fistula, meat intoxication or protein intoxication has been known (Nencki et al 1896;Monguio and Krause 1934), and protein restriction is effective for lowering the blood ammonia level and improving the clinical course. There was no report, however, dealing with hepatic encephalopathy which referred to the variation of blood ammonia level from the view point of diurnal fluctuation.…”

Section: Discussionmentioning

confidence: 99%

Diurnal fluctuation of blood ammonia levels in adult-type citrullinemia.

Yajima

Hirasawa

Saheki

1982

Tohoku J. Exp. Med.

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A 48-year-old man, who was diagnosed as adult-type citrullinemia by quantitative estimation of men cycle enzymes in the liver, showed a regular nocturnal rice of blood ammonia level. In order to elucidate the mechanism of diurnal fluctuation of blood ammonia level, the patient was put into fasting state for four days. The blood ammonia level rose at the night of the first fasting day even though no food was taken, then it decreased gradually and reached the lowest level in the morning of the third fasting day. Intravenous administration of amino acids mixture under the same starved condition gave rise to a significant elevation of blood ammonia level. Based on these results, it was concluded that hyperammonemia of adult-type citrullinemia could result from the accumulation of free ammonia which was produced from thn catabolism of amino acids absorbed frcm the small intestine and surpassed the urea synthesis of defective urea cycle to flood into the blood. Furthermore, the rise of blood ammonia level at the night of the first fasting day suggested that the circadian rhythm of amino acid-carbohydrate metabolim might superimpcse on the process mentioned above, adult-type citrullinemia; hyperammonemia; diurnal fluctuation A 48-year-old man with adult-type citrullinemia has been described in our previous report (Yajima et al. 1981). He showed repetitive episodes of encephalopathy and was diagnosed by quantitative estimation of amino acids and urea cycle enzymes in the liver. In this case, a regular diurnal fluctuation of the blood ammonia level was seen and the drip infusion of glutamate-arginine mixture and oral administration of citrate lowered the blood ammonia level. But the liver function tests of the patient became worse one month after the laparotomy for the evaluation of urea cycle enzymes and he clinically deteriorated to the state of general liver failure with jaundice and ascites. He died two months after the laparotomy. At the stage of general liver failure, citrate ingestion was ineffective and regular diurnal fluctuation of blood ammonia was no longer seen.

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“…Later, Monguio and Krause (1934) correlated these neurological disturbances with raised bloodammonia levels. In the same way, it had been shown that the psychiatric disturbances which frequently follow portacaval anastomosis in man are associated with elevation of blood-ammonia levels (van Caulaert, Deviller, and Halff, 1932).…”

Section: Department Of Surgery Quebn's University Of Belfastmentioning

confidence: 92%