Über die Beeinflussung des Knorpelstoffwechsels durch einen Knorpel-Knochenmark-Extrakt

Stimulation of Articular Chondrocytes of Middle-Aged Mice by a Cartilage-Bone Marrow Extract

“…In vitro, the uptake of 3r'S by costal cartilage of old rats was not increased after administration of the extract to the living animal [5], These findings are not inconsistent with the present results: the composition of cartilage varies with species and location [6-8j and such differences may alter the reaction to stimulation in various ways. In grossly normal articular cartilage of human subjects in their6th to 10th decade of life, the extract stimulated the uptake of S5S and of :1H-serine and thus promoted the synthesis of protein polysaccharides [9].…”

A High Molecular Mucopolysaccharide Peptide Complex Stimulating Connective Tissue Metabolism

“…Tbe results of our experimental work indicate that in addition to active com ponents of low molecular weight tbe cartilage extract contains a high molecular fraction, coded DAK-16, which was isolated by our [21]). By further fractiona tions of the low molecular components of Kumalon® they found that the effective component for the stimulation of sulfate incor poration in cartilage is not due to the amino acid fractions but may be due to nucleic acids derivatives and peptides present in ltumalon®.…”

“…[1|: Weigel and Jasinski [21]; Knrzet and Domenjoz [ 101; Richter [ 14 j : Knrzet et at. [11 j; Kalbhen et at.…”

Editorial

“…It has been shown to stimulate anabolism in cartilage tissue of normal animals [2,3] and mucopolysaccharide biosynthesis by fibroblasts [4]. Certainly there are no known agents which have been shown conclusively to influence joint repair in such degenerative conditions.…”