Über die experimentelle Cholesterinkrankheit der Kaninchen

An experimental model for type V hyperlipoproteinemia: Combined tween and cholesterol treatment in rabbits

“…In the adrenal cortex, interruption of the Tween ~-Cholesterol treatment brings about characteristic changes which are similar to those of cholesterol treated rabbits [13], as well as to those seen in animals under continued stress [14]. In the pancreas we could not detect changes suggestive of thrombosis, as are supposed to occur in type V hyperlipoproteinemia [3], where pancreatitis is of frequent occurrence; it is possible that a more prolonged treatment might have induced this alteration.…”

The Influence of Thyroidectomy, Splenectomy, Gonadectomy, and Suprarenalectomy Upon the Development of Experimental Atherosclerosis in Rabbits

“…In the case of the spleen we may be eliminating a possible storehouse for excess cholesterol because it sometimes undergoes very marked enlargement in the presence of prolonged lipemia. This is well illustrated in experimental lipemia and clinically in Gaucher's disease and in some cases of diabetic lipemia (1, 27,5,15,28,29,30, and others). The relation of the spleen to the reticulo-endothelial system and its function in both the destruction of old red blood ceils and the formation of new erythrocytes emphasizes the possibility that the spleen not only stores cholesterol but also utilizes it.…”

“…Because of their susceptibility to the development of atherosclerosis rabbits have been used in these experiments. It has been possible also to produce the same changes in guinea pigs (Anitschkow and Chalatow (4), SchSnheimer (15)) and in omnivorous animals, especially after castration (L6wenthal (19)).…”