Über die Textur von Stärketabletten

Abstract

JIit Hilfe eines neu entnickelten Queckailber-Pomimeters wurden von Stiirketabletten Textur und andere Eigenschaften bei verschiedeneii Kompressionsdrucken und wechselndem Feuchtigkeitsgehalt verfolgt. Sowohl mit steigendemKompressionsdruck ah auch mit steigendem Feuchtigkeitagehalt verkleinern eich Porenvolumen und haufigster Porenrdius, ebenso der RollverschleiD, wahrend Bruchfestigkeit und Zerfallszeiten sich erhohen. Die Tablettenhohe steht ebenfalls in direkter Beziehung zur Textur, 80 daB danach Porenvolumen und hiiufigster Porenradius ermittelt werden konnen und auch die Feststoffdichte sich annahernd bcstimmen liilt. *) Die Arbeit wurde mit Untersttitzung der Deutschen Forschungsgemeinschaft durchgefiihrt.

Characterisation of pore structures of pharmaceutical tablets: A review

“…Mercury porosimetry was introduced to the pharmaceutical field by Strickland, Busse, and Higuchi, 1956 to measure the apparent density of granulates and the intragranular porosity. Reich and Gstirner, 1968 developed a mercury porosimeter that made it possible to measure from very low to high pressures continuously, which could thus be used to determine the pore sizes ranging from 0.05 to 500 µm. This was demonstrated with the example of starch tablets, where the authors showed that an increase in compression force resulted in a decrease in porosity and pore radius, as well as an extended disintegration time of these tablets.…”

“…Date Measuring apparatus Material Application (Strickland et al, 1956) 1956 Custom-built Glass beads, potassium bromide crystals, sulfathiazole/starch granules, phenobarbital/starch granules, sodium bicarbonate/starch granules, aspirin granules Intragranular porosity (Reich, 1967) ( Reich and Gstirner, 1968) 1968…”

Pharmaceutical Sciences-1969: Literature Review of Pharmaceutics

“…The porosity, pore-size distribution, and water permeability of several different coating powders used for subcoating sulfathiazole tablets were evaluated (324). Powders consisting of acacia, sucrose, titanium dioxide, talc, calcium carbonate, and Aerosil formed the coatings that were considered to have the best properties.…”

An Investigation of the Potential of Soy Cellulose as a Tablet Disintegrant

“…Porosity of tablets has been studied with increasing fre-quency in recent years, using a variety of materials and numerous ( experimental methods. Porosity, void space, and pore size decrease as pressure increases (33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46). Potato and corn starches increase mean pore diameters and porosity (47)(48)(49)(50).…”