Über die Wirkung einer Fettemulsion auf menschliche Thrombocyten in vitro

Coagulation Changes with intravenous Administration of Fat after Blocking the RES

“…In some cases the plateletcount returned to normal after 24 h. This may be due to the mere aggregation of platelets, which have dissolved again within 24 h. The decrease of the platelets then is not due to destruction. By in vitro experiments Pfleiderer (21) and coworkers observed regularly a significant increase of the platelet aggregation after adding this same Lipofundin. Although it is known that the cottonseed oil, contained in Lipofundin, does not act on the contact activation [Connor (5), Didisheim (6)], it was looked for a possible contact activation after the fat infusions, using the contact activation test by Egli and Buscha (7).…”

Dietary Fats and Arterial Thrombosis

“…Lipofundin®, an emulsion of cottonseed oil, when administered to rabbits (2 g oil/kg body weight), decreased the circulating platelet count significantly, but produced an inconsistent effect on platelet retention in the rotating bulb [72]. When added to blood in vitro it invariably gave a significant in crease in platelet aggregation [109]. Later investigations of Pfleiderer et al [110], which included emulsions of a great number of fatty acids and vegetable and mineral oils, revealed that all emulsions, when added to ci trated platelet-rich plasma or citrated blood, increased platelet stickiness.…”