Über Hydromorphin

Oldenberg, L.

doi:10.1002/cber.19110440290

Cited by 18 publications

(2 citation statements)

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“…80,81 Then, in 1911, Oldenberg found that morphine and codeine both had a double bond that was able to be saturated with hydrogen and palladium to form 14 and 15. 82 A vast amount of work has been done on codeine with PCl 3 , PCl 5 , and SOCl 2 to convert the hydroxyl of codeine into α-chlorocodide (16), which can then be thermally isomerized to β-chlorocodide ). The same year, Knorr found that 18 and 19 could be oxidized to 13 and a pseudocodeinone (20), confirming the relationship between the hydroxyl at position 6 and the location of the double bond relative to the hydroxyl (Figure 10).…”

Section: Acs Chemical Neurosciencementioning

confidence: 99%

“…Then, in 1911, Oldenberg found that morphine and codeine both had a double bond that was able to be saturated with hydrogen and palladium to form 14 and 15 . A vast amount of work has been done on codeine with PCl 3 , PCl 5 , and SOCl 2 to convert the hydroxyl of codeine into α-chlorocodide ( 16 ), which can then be thermally isomerized to β-chlorocodide ( 17 ).…”

Section: Introductionmentioning

confidence: 99%

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DARK Classics in Chemical Neuroscience: Opium, a Historical Perspective

Presley

Lindsley

2018

ACS Chem. Neurosci.

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Opium is the latex from the opium poppy Papaver somniferum L., which humankind has utilized since ancient Mesopotamia all the way to modern times. Opium used to be surrounded in divine mystery or magic-like abilities and was given to cure a wide variety of diseases until its analgesic, antitussive, and antidiarrheal properties were understood, the resulting alkaloids were isolated, and their structure and properties unmasked. Opium went from being sold in any store front in the form of pills or tinctures with no prescription necessary for purchase or smoked in an opium den down the street, to then bringing about consumer advocacy and the right to know what is in a medication. Legislation was created to limit the prescribing and selling of medications to doctors and pharmacists as well as outlawing opium dens and smoking opium. This review focuses primarily on the uses of opium throughout history, the isolation of the principle alkaloids, and their structure elucidation.

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Section: Acs Chemical Neurosciencementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%