Über Muskeladenylsäure und Hefeadenylsäure.

The Metabolic Systems: Anaerobic Metabolism (Glycolytic and Phosphagen)

“…In the late 1920s, Embden's group (58,59) discovered muscle adenylic acid, but its significance was not immediately obvious (123, p. 14). In 1928, Karl Lohmann (1898-1978) found a substance in trichloroacetic acid extracts of muscle that could be hydrolyzed into inorganic phosphate (107,108).…”

The physiological activity of adenine compounds with especial reference to their action upon the mammalian heart1

“…Among other effects upon the heart, they slow the rate of beating, impair conduction from auricle to ventricle, and arrest experimentally produced auricular fibrillation; they shorten the absolute refractory period of and improve slowed conduction in the auricle due to high rates of beating. 6. They lower general arterial pressure.…”

“…E mb den and his co-workers (4,5,6) consider that the deamination of adenylic acid is one of the earliest events in muscular activity. We have therefore investigated the action of adenosine upon the contraction of the tibialis anticus in the cat to determine its influence upon the contraction process itself.…”

“…The heart beat is recorded electrocardiographically from two needles inserted beneath the skin of the right fore leg and left hing leg respectively. Analysis of the records thus obtained shows that about 3 seconds after the beginning of the injection heart block abruptly develops, which is initially complete but which after about 6 seconds passes gradually off through the stages of 3 : 1, 2 : 1 block, 1 : 1 response with prolonged P-R intervals; the preinjection condition being reached in [9][10][11][12] Prof. Embden has kindly supplied us with his muscle adenylic acid and we have been able to make some further comparative observations. The mixed melting point of adenylic acid and of our substance is identical with that of either substance alone.…”

Wissenschaftliche und technische Sammelreferate

“…In den letzten Jahren sind von Embden und seinen Mitarbeitern (18,19,95,96) und von Deuticke (20,21) im Embden'scben Laboratorium eine (3ruppe yon kolloidchemischen Ver~inderungen als Folge der Muskelt~itigkeit aufgefunden worden, die mit dem Ablauf der chemischen Prozesse einerseits und der Feinstruktur des Muskels anderseits in Beziehung zu stehen scheinen. Waren die bisher beschriebenen Ver/inderungen reversibel, yon Zuckung zu Zuckung innerhalb physiologischer Grenzerl reproduzierbar, so sind diese Ver~tnderungen in dem Sinne nicht mehr reproduzierbar, sondern nehmen mit zunehmender Zuckungszahl in charakteristischer Weise zu.…”