Über neuraminsäurehaltige Mucoide aus Menschenerythrocytenstroma, ein Beitrag zur Chemie der Agglutinogene

The Crossreaction of Anti-N with Type M Erythrocytes

“…Studies by Uhlenbruck [6,15,16] and Uhlenbruck and Krüpe [17], have shown that, by either enzyme or phenol-water extraction, mucopolysaccharides inhibiting both anti-M and anti-N were always obtained from type MU red cells but not from type Mu. In contrast, only N inhibitor was obtained from type N cells.…”

Erythrocyte Mucoids

“…Subsequently several research teams have succeeded independently in isolating similar material from human erythrocyte stroma (Baranowski et al [1], Klenk and Uhlenbruck [10], Stalder and Springer [24], Kathan, Winzler and Johnson [6]) by a modification of Westphal's phenol/water extraction method for bacteria [36], first used for erythrocyte extraction by Hohorst [3] in order to obtain MN-active substances.…”

Possible Genetical Pathways in the MNSsUu System

“…The impossi bility of showing any inhibition in the U system may be due to the fact that, since protein structures seem to play a specific role in the MN system [Lisowska and Morawiecki, 1967, 24] the same may hold for the U antigen. However, by the procedure employed the MNSs substances are isolated from the red cells [18], so that a dénaturation of the protein part cannot be excluded and this may be the explanation of the above results.…”