Über Vorhofflimmern und Vorhofflattern

Rothberger, C. J.; Winterberg, H.

doi:10.1007/bf01680717

Cited by 73 publications

(8 citation statements)

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“…If the vagi are then stimulated, atrial fibrillation recurs and persists (8). The probable role of vagal tonus in such experimental models is its effect on atrial recovery time (9). The average atrial refractory time is shortened by vagal stimulation in a nonhomo‐geneous manner.…”

Section: Discussionmentioning

confidence: 99%

Tachyarrhythmias in Old Age

Vaidya¹,

Bhosley

Rao³

et al. 1976

J American Geriatrics Society

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The electrocardiograms of 1,171 patients above the age of 65 in a predominantly geriatric institution were reviewed to determine the incidence of tachyarrhythmias. Data on the overall incidence and the individual types of arrhythmias are presented. Atrial fibrillation was the most common arrhythmia observed, followed by atrial flutter and supraventricular tachycardia. Atrial fibrillation often was associated with other evidence of myocardial damage. The significance of sinus bradycardia and grade I A-V block in the pathogenesis of atrial fibrillation and the significance of the tachyarrhythmias are discussed.

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Section: Discussionmentioning

confidence: 99%

Tachyarrhythmias in Old Age

Vaidya¹,

Bhosley

Rao³

et al. 1976

J American Geriatrics Society

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“…This change in view about the origin of flutter results from the observation that the atrial arrhythmia elicited in dogs by the topical application of aconitine to the atrial surface responded to vagal stimulation by an increase in atrial rate and occasional conversion into atrial fibrillation (Scherf, 1947;Scherf, Romano & Terranova, 1948;Scherf, Schaffer & Blumenfeld, 1953). Many years earlier the same vagal response was obtained during atrial flutter produced by faradization (Rothberger & Winterberg, 1914). Suppression of the atrial arrhythmia by vagus stimulation in the two conditions was only infrequently obtained (Lewis, Drury & Bulger, 1921 ;Scherf & Terranova, 1949;Scherf, Blumenfeld, Mueller & Beinfield, 1953).…”

Section: Discussionmentioning

confidence: 99%

Suppression of Ouabain‐induced Atrial Arrhythmias by Carotid Sinus Stimulation

Schott

1961

British Journal of Pharmacology and Chemotherapy

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In dogs anaesthetized with chloralose ectopic atrial arrhythmias were produced by subepicardial injection of ouabain. Stimulation of the right carotid sinus abruptly suppressed the ectopic arrhythmias. They returned on cessation of stimulation and sometimes already during the period of stimulation. It is suggested that in view of its response to carotid sinus stimulation the ouabain-induced arrhythmia resembles paroxysmal atrial tachycardia and that it is distinct from the aconitine-induced arrhythmia which on account of its response to vagal stimulation has been classified as atrial flutter.It is well known to clinicians that attacks of atrial paroxysmal tachycardia can often be terminated by carotid sinus pressure whereas this procedure is ineffective in atrial flutter. It is equally well known that different types of atrial arrhythmias can be produced in animals by local application of various drugs to the epicardial surface of the heart (Scherf, 1944(Scherf, , 1947Kisch, 1944;Scherf & Chick, 1951;Prinzmetal, Corday, Brill, Oblath & Kruger, 1952;Scherf, Blumenfeld, Taner & Yildiz, 1960), but it has never been shown that any of these resemble paroxysmal atrial tachycardia in man by the crucial test of being consistently suppressible by means of carotid sinus stimulation. It has now been found that the arrhythmia produced by subepicardial injection of ouabain is regularly susceptible to carotid sinus stimulation. METHODSDogs weighing between 9 and 14 kg were premedicated with morphine, 1 mg/kg injected subcutaneously, and anaesthetized with chloralose, 0.1 g/kg injected intravenously. The blood pressure was recorded from a femoral artery and a cannula was inserted into the trachea.In all experiments stimulation of the carotid sinus was carried out on the right side with both sinus and aortic nerves intact in order to approximate the effects obtained in man, where pressure on the right carotid sinus is more frequently effective in terminating attacks of atrial paroxysmal tachycardia (Scherf & Schott, 1953). The right carotid sinus was exposed, and stimulating shielded platinum electrodes were applied to the dissected sinus nerve and connected to a transistor stimulator (Joslin, 1959). Stimulation was carried out with impulses of 15 V, 1 msec, 100/sec. In a few experiments the innervated right carotid sinus was isolated, according to the method of Moissejeff (1927), making possible its distension by introducing liquid into it, and at the same time recording the intrasinusal pressure.After dissection of the carotid sinus, the sternum was split, the chest opened in the midline to expose the heart, while artificial respiration was given with a Starling (" Ideal ") pump.

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“…Reintroduction of the stimulus had no effect since those fibres which had been in phase with the stimulus were now also fibrillating. Rothberger & Winterberg (1915), and others since, have shown that vagal stimulation converts flutter into fibrillation. The converse of this was repeatedly seen in our experiments.…”

Section: Acetylcholine and Auricular Fibrillation 289mentioning

confidence: 91%