“…All these chains vary in length, ranging from two to more than ten residues. They can be homotypic if the same residue is modified during elongation as in M1, K11, 48 or 63-linked chains, or heterotypic if the same chain displays different linkages [21,22]. Moreover, a single ubiquitin can be modified with multiple chains or UBLs (NEDD8, SUMO, ISG15), generating branched chains or mixed chains, respectively.…”