Ubiquitin specific peptidase 11 as a novel therapeutic target for cancer management

Liao, Yihao; Zhou, Diansheng; Wang, Pu; Yang, Mengyue; Jiang, Ning

doi:10.1038/s41420-022-01083-5

Cited by 13 publications

(4 citation statements)

References 125 publications

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“…USP11 promotes tumor growth and metastasis in CRC via the ERK/MAPK pathway by stabilizing PPP1CA[ 66 , 67 ].…”

Section: Discussionmentioning

confidence: 99%

Comprehensive analysis of the role of ubiquitin-specific peptidases in colorectal cancer: A systematic review

Al-Balushi,

Al Marzouqi,

Tavoosi

et al. 2024

World J Gastrointest Oncol

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BACKGROUND Colorectal cancer (CRC) is the third most frequent and the second most fatal cancer. The search for more effective drugs to treat this disease is ongoing. A better understanding of the mechanisms of CRC development and progression may reveal new therapeutic strategies. Ubiquitin-specific peptidases (USPs), the largest group of the deubiquitinase protein family, have long been implicated in various cancers. There have been numerous studies on the role of USPs in CRC; however, a comprehensive view of this role is lacking. AIM To provide a systematic review of the studies investigating the roles and functions of USPs in CRC. METHODS We systematically queried the MEDLINE (via PubMed), Scopus, and Web of Science databases. RESULTS Our study highlights the pivotal role of various USPs in several processes implicated in CRC: Regulation of the cell cycle, apoptosis, cancer stemness, epithelial–mesenchymal transition, metastasis, DNA repair, and drug resistance. The findings of this study suggest that USPs have great potential as drug targets and noninvasive biomarkers in CRC. The dysregulation of USPs in CRC contributes to drug resistance through multiple mechanisms. CONCLUSION Targeting specific USPs involved in drug resistance pathways could provide a novel therapeutic strategy for overcoming resistance to current treatment regimens in CRC.

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“…USP11 promotes tumor growth and metastasis in CRC via the ERK/MAPK pathway by stabilizing PPP1CA[ 66 , 67 ].…”

Section: Discussionmentioning

confidence: 99%

Comprehensive analysis of the role of ubiquitin-specific peptidases in colorectal cancer: A systematic review

Al-Balushi,

Al Marzouqi,

Tavoosi

et al. 2024

World J Gastrointest Oncol

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“…Ubiquitin specific peptidase 11 (USP11) inactivation has also been associated with AD. USP11 is a deubiquitinase involved in chromatin condensation, genomic stability, and cell survival ( Liao et al, 2022 ). USP11 had been shown to escape inactivation and increase τau pathology in AD brains, mostly in women ( Yan et al, 2022 ).…”

Section: The Role Of Sex In the Pathogenesis Of Adrdmentioning

confidence: 99%

Sex-based differences in effector cells of the adaptive immune system during Alzheimer's disease and related dementias

Lutshumba

Wilcock

Monson

et al. 2023

Neurobiology of Disease

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“…Additionally, USP11 has promoted the accumulation of MLF2 in all tested cells ( 60 ), whereas MLF1 and MLF2 are approximately 40% similar ( 11 ). USP11 plays a dual role in the development of tumors ( 61 , 62 ). Based on the studies conducted so far, MLF1 may act as both a tumor suppressor and tumor oncogene, depending on the context of the cell.…”

Section: Mlf1 Networkmentioning

confidence: 99%

Myeloid leukemia factor 1: A “double-edged sword” in health and disease

Yang²,

Wu³

et al. 2023

Front. Oncol.

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The occurrence and development of malignancies are closely related to abnormal cell cycle regulation. Myeloid leukemia factor 1 (MLF1) is a small nucleocytoplasmic shuttling protein associated with cell cycle exit, apoptosis, and certain immune functions. Therefore, it is pertinent to explore the role of MLF1 in health and diseases. Studies to date have suggested that MLF1 could act as a double-edged sword, regulating biochemical activities directly or indirectly. In hematopoietic cells, it serves as a protective factor for the development of lineages, and in malignancies, it serves as an oncogenesis factor. The diversity of its functions depends on the binding partners, including tumor inhibitors, scaffolding molecules, mitochondrial membrane proteins, and transcription factors. Emerging evidence indicates that MLF1 influences immune responses as well. This paper reviews the structure, biological function, and research progress on MLF1 in health and diseases to provide new insights for future research.

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Ubiquitin specific peptidase 11 as a novel therapeutic target for cancer management

Cited by 13 publications

References 125 publications

Comprehensive analysis of the role of ubiquitin-specific peptidases in colorectal cancer: A systematic review

Comprehensive analysis of the role of ubiquitin-specific peptidases in colorectal cancer: A systematic review

Sex-based differences in effector cells of the adaptive immune system during Alzheimer's disease and related dementias

Myeloid leukemia factor 1: A “double-edged sword” in health and disease

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