Computer‐aided diagnosis is pivotal in augmenting the diagnostic efficiency of ultrasound images. Nonetheless, the substantial presence of noise and artifacts in ultrasound images presents a challenge to the precise segmentation of the target region. To highlight and analyze the diagnostic information such as tissues, organs, and lesions in ultrasound medical images more accurately, a target region extraction method combining the improved PRIDNet and UCTransNet for ultrasound medical images is proposed. The method sequentially enhances and segments the target region of the image, thereby solving the problem of inconspicuous target region caused by noise and artifacts in ultrasound images. There are three key characteristics: (i) The feature extraction part of the enhancement network (improved PRIDNet) is redesigned for speckle noise to improve the network's ability to extract information and highlight the feature information of the target region in ultrasound images. (ii) The segmentation network with the addition of the underlying information on UCTransNet would effectively improves Channel‐wise Cross fusion Transformer (CCT) and decoder feature fusion capability. (iii) By combining the enhancement network with the segmentation network, we can further improve the segmentation accuracy of the target region in the presence of noise interference. The experiments conducted on both UFSU that we prepared and on some public datasets including BUSI, FHC, and CT2US have demonstrated that The proposed method attains MIoU, DSC, Acc, and HD of 96.34%, 98.12%, 99.35%, and 8.64 in CT2US, respectively. The method significantly surpasses those certain state‐of‐the‐art methods, demonstrating its potential to offer valuable guidance for clinical treatment. The code will be publicly released at https://github.com/425877/Target-Region-Extraction-Method-for-Ultrasound-Medical-Images.