Ueber Benzoltetrasulfid und p‐Toluoltetrasulfid; nach untersuchungen von A. Milch

Milch, Amrei; Otto, Robert

doi:10.1002/prac.18880370118

Cited by 8 publications

(1 citation statement)

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“…The power to combine with cations may be the cause of the absence of reports that these tetracyclines affect the faster growing cells of host animals such as blood cells which are affected by the inhibitor of protein synthesis, chloramphenicol : the tetracyclines may not be able to reach the blood producing centres in the molecular inhibitory form because of the availability of calcium in the bone. Milch, Rall and Tobie (1957) report that interperitoneally injected tetracycline induces fluorescence in the bones of several species of laboratory animals, and we find that filtering an aqueous solution of tetracycline through powdered calcium ortho-phosphate severely decreases the inhibitory power.…”

Section: Tetracycllne and Oxytetracyclinementioning

confidence: 73%

The Bacteriostatic Actions of Tetracycline and Oxytetracycline

Jones

Morrison

1962

Journal of Pharmacy and Pharmacology

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The bacteriostatic actions of tetracycline and oxytetracycline on cultures of A. aerogenes in glucose‐mineral salt media have been studied. Both antibiotics show two modes of action, one of which is non‐operative under aerobic conditions and is ascribed to an interference with the disposal of hydrogen in unaerated cultures. The other mode of action can be accounted for by an interference with the synthesis of protein. Quantitative measurements of the dependence of the degree of inhibition on the pH and the concentration of magnesium ions are in accord with attributing inhibitory power solely to the non‐ionic molecular forms of the antibiotics. The possible contributions of the two modes of action to the cytotoxic action are discussed.

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Section: Tetracycllne and Oxytetracyclinementioning

confidence: 73%