Ueber das Aethylenimin (Spermin?)

Ladenburg, A.; Abel, J. E.

doi:10.1002/cber.188802101139

Cited by 33 publications

(9 citation statements)

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“…Their initial discovery was made as early as 1678, when "three-sided" crystals from human semen were Wrst described (van Leeuwenhoek 1678). Because the described polyamine occurs in high concentration in sperm, the name spermine [N,butane-1,4-diamine] was designated (Ladenburg and Abel 1888). The structure and chemical synthesis of this compound were not established until much later (1926) (Dudley et al 1926;Wrede 1925).…”

Section: Introductionmentioning

confidence: 98%

Polyamines: essential factors for growth and survival

Kusano

Berberich

Tateda

et al. 2008

Planta

788

574

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Polyamines are low molecular weight, aliphatic polycations found in the cells of all living organisms. Due to their positive charges, polyamines bind to macromolecules such as DNA, RNA, and proteins. They are involved in diverse processes, including regulation of gene expression, translation, cell proliferation, modulation of cell signalling, and membrane stabilization. They also modulate the activities of certain sets of ion channels. Because of these multifaceted functions, the homeostasis of polyamines is crucial and is ensured through regulation of biosynthesis, catabolism, and transport. Through isolation of the genes involved in plant polyamine biosynthesis and loss-of-function experiments on the corresponding genes, their essentiality for growth is reconfirmed. Polyamines are also involved in stress responses and diseases in plants, indicating their importance for plant survival. This review summarizes the recent advances in polyamine research in the field of plant science compared with the knowledge obtained in microorganisms and animal systems.

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Section: Introductionmentioning

confidence: 98%

Polyamines: essential factors for growth and survival

Kusano

Berberich

Tateda

et al. 2008

Planta

788

574

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“…Polyamines are low molecular weight aliphatic nitrogenous bases which are derivatives of protein digestion (Ladenburg, 1888;Leeuwenhoek and Observationes, 1678) and synthesized by almost all cells in varying quantities. They are essential for cell growth (Nitta et al, 2002;Thomas and Thomas, 2001), differentiation and proliferation.…”

Section: Introductionmentioning

confidence: 99%

The effects of polyamines on human colonic mucosal function

Rogers

McDermott

Mohan

et al. 2015

European Journal of Pharmacology

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“…Crystals of SPM phosphate were discovered and described in human semen, by Anton van Leeuwenhoek in 1678 [54]. The name spermin was first used by the German chemists Ladenburg and Abel in 1888 [55], but the correct structure of SPM was not definitely established until 1925, almost simultaneously in two independent laboratories [56,57].…”

Section: Spermine and Polyamines Metabolismmentioning

confidence: 99%

Spermine Metabolism and Anticancer Therapy

Amendola

Cervelli

Fratini³

et al. 2009

CCDT

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The natural polyamines (PA), putrescine (PUT), spermidine (SPD) and spermine (SPM) are ubiquitous constituents of eukaryotic cells. The increase of PA in malignant and proliferating cells attracted the interest of scientists during last decades, addressing PA depletion as a new strategy to inhibit cell growth. Selective enzyme inhibitors were developed for decreasing PA metabolism and to act as chemotherapeutic anticancer agents. Indeed, the complexity of the PA homoeostasis overcomes the PA perturbation by a single enzyme to take effect therapeutically. Recently, an increasing interest has been posed on spermine-oxidase (SMO), the only catabolic enzyme able to specifically oxidise SPM. Interestingly, the absence of SPM is compatible with life, but its accumulation and degradation is lethal. Augmented SMO activity provokes an oxidative stress rendering cells prone to die, and appears to be important in the cell differentiation pathway. Extra-cellular SPM is cytotoxic, but its analogues are capable of inhibiting cell growth at low concentrations, most likely by intracellular SPM depletion. These pivotal roles seem to evoke the biological processes of stress response, wherein balance is mandatory to live or to die. Thus, altering SPM metabolism could allow a multi-tasking therapeutic strategy, addressed not only to inhibit PA metabolism. Several tetramines are presently in early phases (I and II) of clinical trials, and it will be a matter of a few more years to understand whether SPM-related therapeutic approaches would be of benefit for composite treatment protocols of cancer.

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Ueber das Aethylenimin (Spermin?)

Cited by 33 publications

References 0 publications

Polyamines: essential factors for growth and survival

Polyamines: essential factors for growth and survival

The effects of polyamines on human colonic mucosal function

Spermine Metabolism and Anticancer Therapy

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