Ueber das Keratoma palmare et plantare hereditarium

Unna, P. G.

doi:10.1007/bf01833456

Cited by 52 publications

(16 citation statements)

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“…Heterozygous mutations in KRT1 and KRT9 , encoding for the suprabasal keratins 1 (K1) and 9 (K9) (Table ), have been reported to cause three different forms of diffuse hereditary PPKs: epidermolytic PPK (EPPK) Thost–Unna/Vörner and Greither's types and a nonepidermolytic PPK (NEPPK) type due to KRT1 mutation. PPKs associated with KRT1/KRT9 mutations represent the commonest forms of hereditary PPKs.…”

Section: Isolated Palmoplantar Keratodermasmentioning

confidence: 99%

Hereditary palmoplantar keratodermas. Part I. Non‐syndromic palmoplantar keratodermas: classification, clinical and genetic features

Guerra

Castori

Didona

et al. 2018

Acad Dermatol Venereol

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The term palmoplantar keratoderma (PPK) indicates any form of persistent thickening of the epidermis of palms and soles and includes genetic as well as acquired conditions. We review the nosology of hereditary PPKs that comprise an increasing number of entities with different prognoses, and a multitude of associated cutaneous and extracutaneous features. On the basis of the phenotypic consequences of the underlying genetic defect, hereditary PPKs may be divided into the following: (i) non-syndromic, isolated PPKs, which are characterized by a unique or predominant palmoplantar involvement; (ii) non-syndromic PPKs with additional distinctive cutaneous and adnexal manifestations, here named complex PPKs; (iii) syndromic PPKs, in which PPK is associated with specific extracutaneous manifestations. To date, the diagnosis of the different hereditary PPKs is based mainly on clinical history and features combined with histopathological findings. In recent years, the exponentially increasing use of next-generation sequencing technologies has led to the identification of several novel disease genes, and thus substantially contributed to elucidate the molecular basis of such a heterogeneous group of disorders. Here, we focus on hereditary non-syndromic isolated and complex PPKs. Syndromic PPKs are reviewed in the second part of this 2-part article, where other well-defined genetic diseases, which may present PPK among their phenotypic manifestations, are also listed and diagnostic and therapeutic approaches for PPKs are summarized.

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Section: Isolated Palmoplantar Keratodermasmentioning

confidence: 99%

Hereditary palmoplantar keratodermas. Part I. Non‐syndromic palmoplantar keratodermas: classification, clinical and genetic features

Guerra

Castori

Didona

et al. 2018

Acad Dermatol Venereol

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“…Thost (3) and later Unna (4) in the 1880s described diffuse palmar‐plantar keratoderma of nonepidermolytic hyperkeratosis in two different families. The characteristic clinical features are diffuse yellowish thickening on the palms and soles with a clear line of demarcation at the sides without extension to the dorsum of the hands or feet.…”

Section: Discussionmentioning

confidence: 99%

Palmar‐Plantar Keratoderma of Unna Thost Associated with Atopic Dermatitis: An Underrecognized Entity?

Loh

Yosipovitch

Tay

2003

Pediatric Dermatology

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We report six cases of palmar-plantar keratoderma of Unna Thost (PPKUT) associated with atopic dermatitis. All had typical features of PPKUT with diffuse, yellowish thickening on the palms and soles with a well-defined erythematous rim of demarcation on the sides associated with palmar-plantar hyperhidrosis. The changes were obvious since birth or arose during early life, and were persistent. We believe that the association between the two disorders is not coincidental but an underrecognized entity that may shed light on the underlying pathogenesis of these two conditions.

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“…Unna-Thost PPK [33,34] Also known as, Thost-Unna keratoderma. It is a type of diffuse Palmoplantar Keratoderma.…”

Section: Remarksmentioning

confidence: 99%

Eponyms in the dermatology literature linked to Palmo-Plantar Keratoderma

Aboud¹,

Aboud²

2013

Our Dermatol Online

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Historical ArticlePalmoplantar keratodermas (PPKs) represent a diverse group of hereditary and acquired disorders characterized by hyperkeratosis of the skin on the palms and soles [1]. The three major patterns of involvement are diffuse, focal and punctate. There are clinical distinguishing features for each disease in this group, for example, transmigration to areas beyond the palmoplantar skin. Also the extent of associated systemic symptoms if present help in characterization of each type.Although a number of classifications of keratodermashave been published, none unite satisfactorily clinical presentation, pathology and molecular pathogenesis. We based our concise review of selected eponyms linked to PPK (Tabl. I) , on the classifications published in the current editions of two major textbooks in dermatology; Rook's Textbook of Dermatology and Dermatology by Jean L Bolognia.

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Ueber das Keratoma palmare et plantare hereditarium

Cited by 52 publications

References 0 publications

Hereditary palmoplantar keratodermas. Part I. Non‐syndromic palmoplantar keratodermas: classification, clinical and genetic features

Hereditary palmoplantar keratodermas. Part I. Non‐syndromic palmoplantar keratodermas: classification, clinical and genetic features

Palmar‐Plantar Keratoderma of Unna Thost Associated with Atopic Dermatitis: An Underrecognized Entity?

Eponyms in the dermatology literature linked to Palmo-Plantar Keratoderma

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