UEG Week 2018 Oral Presentations

Laursen, Stig Borbjerg; Oakland, Kathryn; Laine, Loren; Bieber, Vered; Marmo, Riccardo; Cerezo, Eduardo Redondo; Dalton, Harry R.; Ngu, Jing Hieng; Schultz, Michael; Gralnek, Ian M.; Jairath, Vipul; Murray, A S; Stanley, AJ

doi:10.1177/2050640618792817

Cited by 7 publications

(2 citation statements)

References 235 publications

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“…Незважаючи на значні успіхи, досягнуті в сучасній гастроентерології, відбувається неухильне поширення захворювань органів травлення, особливо серед дитячого населення -з 60-80‰ до 140-200‰ [1,2]. У структурі патології органів травлення 1,7-16% становить виразкова хвороба, яка у 90% випадків асоціюється з інфекцією H.pylori [3]. Сьогодні медико-соціальне значення цієї патології визначають не лише суттєвим її поширенням у найбільш значущі періоди росту і розвитку дитини, яким є шкільний вік, але й хронічним рецидивуючим перебігом, формуванням ускладнених форм захворювання, що у низці випадків призводить до інвалідизації [4].…”

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Evaluation of Effectiveness of Comprehensive Treatment of Duodenal Ulcer in Children

Sorokman¹,

Cherney²

2021

Clin. and experim. pathol.

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In the structure of pathology of the digestive organs 1.7–16% constitute peptic ulcerdisease, which in 90% of cases is associated with H.pylori infection.The aim is to evaluate the effectiveness of comprehensive treatment of duodenal ulcer inchildren.Material and methods: The study included 60 children at the age of 10 -18 years withHelicobacter pylori-associated duodenal ulcer (DU), who were divided into three groupsof 20 people depending on the treatment regimen (protocol, including the donor of nitrogen monoxide and capillary stabilizing preparation).Results. Complex therapy of the disease in children provides faster positive dynamics ofclinical and endoscopic symptoms, increases the frequency of eradication of Helicobacterpylori, the relative risk of recurrence will decrease by 0.57 times when included in thetreatment regimen of nitrogen oxide donor and 0.66 times when used along with theprotocol scheme of the donor nitrogen oxide and capillarotropic drug.Conclusion. Comprehensive treatment of DU provides more stable results of treatmentand decreases the disease recurrences both in the early and late stages of observation.

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Section: вступunclassified

Evaluation of Effectiveness of Comprehensive Treatment of Duodenal Ulcer in Children

Sorokman¹,

Cherney²

2021

Clin. and experim. pathol.

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“…An important contributing factor was the inability to cannulate the pancreatic duct in over one third of patients, which was mainly due to duodenal edema. In comparison, in a large prospective study examining the role of early endoscopic retrograde cholangiopancreaticography (ERCP) with biliary sphincterotomy in patients with acute biliary pancreatitis, cannulation of the bile duct was successful in 78 % [6]. It is noteworthy that in the latter study, ERCP was performed within 24 hours after presentation, whereas in the study by Karjula et al the median time to ERCP was 4.6 days.…”

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confidence: 97%

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Wanrooij¹,

Hooft²

2019

Endoscopy

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The early phase of acute pancreatitis is characterized by a systemic inflammatory response that leads to necrosis of the pancreas parenchyma and/or the pancreatic fat tissue in about 20 % of patients [1]. Acute necrotizing pancreatitis (ANP) is commonly associated with pancreatic duct leakage resulting in extensive damage of the parenchyma and duct(s) of the pancreas, which in turn is associated with disconnected duct syndrome and persistent peripancreatic fluid collections [2]; vice versa, leakage of enzymatic active pancreatic fluid into the pancreas parenchyma is also thought to aggravate damage of the pancreas [2]. After 7-14 days, the inflammatory response attenuates, and during this late phase the course of disease is now mostly determined by whether or not necrotic tissue becomes infected, which occurs in about 30 % of patients with ANP [3]. Mortality rates in patients with infected ANP are high (30 %), and although recent developments in treatment approaches utilizing minimal invasive drainage strategies have improved outcomes, further progress is much needed [4].

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Medical treatment of eosinophilic esophagitis

Franciosi

Gordon

Sinopoulou

et al. 2023

Cochrane Database of Systematic Reviews

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Background Eosinophilic esophagitis (EoE) is a chronic antigen‐mediated eosinophilic inflammatory disease isolated to the esophagus. As a clinicopathologic disorder, a diagnosis of EoE requires a constellation of clinical symptoms of esophageal dysfunction and histologic findings (at least 15 eosinophils/high‐powered microscope field (eos/hpf)). Current guidelines no longer require the failure of response to proton pump inhibitor medications to establish a diagnosis of EoE, but continue to suggest the exclusion of other etiologies of esophageal eosinophilia. The treatment goals for EoE are improvement in clinical symptoms, resolution of esophageal eosinophilia and other histologic abnormalities, endoscopic improvement, improved quality of life, improved esophageal function, minimized adverse effects of treatment, and prevention of disease progression and subsequent complications. Currently, there is no cure for EoE, making long‐term treatment necessary. Standard treatment modalities include dietary modifications, esophageal dilation, and pharmacologic therapy. Effective pharmacologic therapies include corticosteroids, rapidly emerging biological therapies, and proton pump inhibitor medications. Objectives To evaluate the efficacy and safety of medical interventions for people with eosinophilic esophagitis. Search methods We searched CENTRAL, MEDLINE, Embase, ClinicalTrials.gov, and WHO ICTRP to 3 March 2023. Selection criteria Randomized controlled trials (RCTs) comparing any medical intervention or food elimination diet for the treatment of eosinophilic esophagitis, either alone or in combination, to any other intervention (including placebo). Data collection and analysis Pairs of review authors independently selected studies and conducted data extraction and risk of bias assessment. We expressed outcomes as a risk ratio (RR) and as the mean or standardized mean difference (MD/SMD) with 95% confidence interval (CI). We assessed the certainty of the evidence using GRADE. Our primary outcomes were: clinical, histological, and endoscopic improvement, and withdrawals due to adverse events. Secondary outcomes were: serious and total adverse events, and quality of life. Main results We included 41 RCTs with 3253 participants. Eleven studies included pediatric patients while the rest recruited both children and adults. Four studies were in patients with inactive disease while the rest were in patients with active disease. We identified 19 intervention comparisons. In this abstract we present the results of the primary outcomes for the two main comparisons: corticosteroids versus placebo and biologics versus placebo, based on the prespecified outcomes defined of the primary studies. Fourteen studies compared corticosteroids to placebo for induction of remission and the risk of bias for these...

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UEG Week 2018 Oral Presentations

Cited by 7 publications

References 235 publications

Evaluation of Effectiveness of Comprehensive Treatment of Duodenal Ulcer in Children

Evaluation of Effectiveness of Comprehensive Treatment of Duodenal Ulcer in Children

Bridging the gap or paving the way for uninvited guests?

Medical treatment of eosinophilic esophagitis

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