Uji Efek Antiinflamasi Fraksi Daun Piladang (Solenostemonscutellarioides (L.) Codd)  terhadap Mencit Putih Betina

Aria, Mimi; Verawati, Verawati; Arel, Afdhil; Monika, Monika

doi:10.36434/scientia.v5i2.27

Cited by 6 publications

(14 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Trauma disebabkan oleh pelepasan serotonin, dan histamine pada daerah radang, serta meningkatkan pembentukan prostaglandin pada jaringan yang rusak. Fase kedua: tiga jam setelah injeksi keragenan, akan terjadi pelepasan prostaglandin yang dimediasi bradikinin, sel polimononuklear, leukotriene, dan produksi prostaglandin oleh makrofag (Aria et al, 2015). Penyuntikan karagenan 2% dilakukan secara subkutan dengan tujuan agar terabsorbsi secara pelan dan berdurasi panjang.…”

Section: Uji Aktivitas Anti-inflamasiunclassified

“…Penelitian lainnya juga menunjukkan bahwa ekstrak daun piladang (Solenstemonscutellarioides (L) Codd.) dengan dosis 400 mg/kgBB dapat menurunkan volume eksudat yaitu 0,020 ± 0,01 ml (Aria et al, 2015). Hal ini menunjukkan bahwa ekstrak etanol efektif untuk mengikat senyawa bioaktif yang berperan sebagai antiinflamasi pada konsentrasi 5% s/d 15%.…”

Section: Hasil Dan Pembahasanunclassified

See 1 more Smart Citation

ANTI INFLAMMATORY ACTIVITY OF SUNGKAI LEAVES (Peronema canescens JACK) ETHANOL EXTRACT IN CARRAGEENAN INDUCED MICE

Latief

Fisesa

Sari

et al. 2021

JFSP

View full text Add to dashboard Cite

Anti-inflammatory compounds play a role by inhibiting the formation of prostaglandin mediators, inhibiting the migration of leukocytes to the area of inflammation, and inhibiting the release of prostaglandins from the cells where they are located. Several plant-derived compounds that can act as anti-inflammatory candidates are flavonoids, saponins, alkaloids, and phenols. This study aims to determine the anti-inflammatory activity of the ethanol extract of Sungkai leaves and to determine the effect of the concentration given on the level of anti-inflammatory activity. The method used was the formation of granuloma pockets and edema on the mice's backs by inducing subcutaneous carrageenan using ethanol extract of Sungkai leaves with various concentrations of 5%, 10%, and 15%, respectively. The results of anti-inflammatory activity showed that the ethanol extract of Sungkai leaves had a significant effect on the average exudate volume and the percentage of inflammation inhibition. At a concentration of 15%, the extract was able to reduce the volume of exudate by 46,67 ± 5,506 µl and inhibition of inflammation by 87.78%. In addition, the ethanol extract of Sungkai leaves significantly affected lymphocytes, stem neutrophils, and segment neutrophils, but did not significantly affect the number of monocyte cells. At a concentration of 15%, the ethanol extract of Sungkai leaves showed the smallest number of leukocyte cell types, namely 50.11 ± 2.389 lymphocyte cells; stem neutrophil cells 10,44 ± 0,475; segmented neutrophil cells were 19.78 ± 0.596 and monocyte cells 2,0 ± 0,236. It can be concluded that the ethanol extract of Sungkai leaves has anti-inflammatory activity but has not approached the effect of anti-inflammatory drugs in general.

show abstract

Section: Uji Aktivitas Anti-inflamasiunclassified

Section: Hasil Dan Pembahasanunclassified

ANTI INFLAMMATORY ACTIVITY OF SUNGKAI LEAVES (Peronema canescens JACK) ETHANOL EXTRACT IN CARRAGEENAN INDUCED MICE

Latief

Fisesa

Sari

et al. 2021

JFSP

View full text Add to dashboard Cite

show abstract

“…The inflammation was induced by using carrageenan according to the method described by Aria et al [4]. A total of 25 mice was used and anesthetized using 0.1 ml of ketamine-xylazine.…”

Section: Induction Of Inflammationmentioning

confidence: 99%

“…The inflammatory response can be reduced through the administration of non-steroidal anti-inflammatory drugs (NSAIDs) which play a role in suppress the inflammatory mechanism [3]. Inflammation treatment is carried out with two main goals; relieve pain and stop the process of tissue damage [4].…”

Section: Introductionmentioning

confidence: 99%

“…The duration of the inflammatory process can be affected by the substances contained in the drug given. The effectiveness of a drug can be seen from the decrease in the volume of edema produced [4]. The administration of NSAIDs is known to have side effects such as kidney problems [5] so that effective anti-inflammatory drugs are developed to prevent secondary inflammation by using traditional medicinal plants.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Anti-Inflammation Activity of Ethyl Acetate Extract of Malacca Leaves (Phyllanthus emblica)

Asmilia¹,

Armansyah²,

Herrialfian³

et al. 2021

Advances in Biological Sciences Research

View full text Add to dashboard Cite

This study aims to evaluate the anti-inflammation activity of ethyl acetate extract of Malacca leaf (Phyllanthus emblica) in mice. The study used 25 mice which were induced by subcutaneous injection of 1 % carrageenan. The mice were divided into 5 treatment groups: K1 was negative control, K2 (positive control) was given piroxicam suspension at dose of 20 mg/kg BW, while K3, K4, and K5 were given Malacca leaf extract at dose of 100, 200, and 300 mg/kg BW, respectively, by oesophageal intubation for 4 days. On day 5, the edema volume was measured and the differential leucocytes were counted. The data were analyzed using one way Analysis of variance (ANOVA). The lowest edema volume was observed in mice treated with different doses of Malacca leaves extract (K2, K3, K4) and significantly different (P<0.05) compared to mice in K1 and K2. The percentage of neutrophils was significantly lower in groups K2, K3, K4, and K5 than in groups K1. In contrast, the percentage of eosinophil, lymphocytes and monocytes were significantly higher (P<0.05) in K2, K3, K3, and K4 as compared to those in K1. The basophils percentage were similar among the groups, except for K4 which had the highest value (P<0.05) compared to other groups. It is concluded that the administration of ethyl acetate extract of Malacca leaves can reduce the edema volume and affect the number of leukocytes in carrageenan-induced mice.

show abstract

Efek Pemberian Gel Ekstrak Etanol Daun Ekor Naga (Rhaphidophora pinnata (L.f) Schott) Sebagai Antiinflamasi Metode Carrageenan-Induced Air Pouch

Sani K,

Simamora,

Rahman

et al. 2023

J. Sains Kes.

View full text Add to dashboard Cite

The ethanol extract ekor naga leaves (Rhaphidophora pinnata (L.f) Schott) has been studied as an anti-inflammatory agent. This study aims to formulate a topical preparation of ekor naga leavesextract gel so that it can be a futher step from previous research as a product development effort. The research method used is experimental design. The treatment group was divided into five groups: positive control (Hydrocortisone), Formula 0 (Gel Base), Formula 1 (10% Extract Concentration), Formula 2 (15% Extract Concentration), and Formula 3 (20% Extract Concentration). The test animals used in each treatment group were 5 animals. The data obtained were analyzed using one way ANOVA with a 95% confidence level. The results showed that the more extracts, the better the anti-inflammatory effect. However, based on preparation evaluation data in previous studies regarding gel formulations, it was concluded that formula 2 was the best formula with an effect that was statistically almost the same as formula 3 and had good gel stability in the formulation. Keywords: Ekor Naga Leaves, Gel, Inflammation, Air Pouch Abstrak Ekstrak etanol daun ekor naga (Rhaphidophora pinnata (L.f) Schott) telah diteliti memiliki efek sebagai agen antiinflamasi. Penenlitian ini bertujuan untuk memformulasi sediaan topikal gel ekstrak daun ekor naga sehingga dapat menjadi menjadi langkah lanjut dari penelitian sebelumnya sebagai upaya pengembangan produk. Metode penelitian yang digunakan adalah experimental design. Kelompok perlakuan dibagi menjadi lima kelompok yaitu: Kontrol positif (Hidrokortisone), Formula 0 (Basis Gel), Formula 1 (Konsentrasi Ekstrak 10%), Formula 2 (Konsentrasi Ekstrak 15%), dan Formula 3 (Konsentrasi Ekstrak 20%). Hewan uji yang digunakan masing-masing kelompok perlakuan 5 ekor. Data yang didapat dianalisis menggunakan ANOVA satu arah dengan tingkat kepercayaan 95%. Hasil penelitian menunjukkan bahwa semakin banyak ekstrak maka semakin baik efek antiinflamasinya. Namun berdasarkan data evaluasi sediaan pada penelitian sebelumnya tentang formulasi gel maka disimpulkan bahwa formula 2 merupakan formula terbaik dengan efek yang secara statistic hampir sama dengan formula 3 serta memiliki stabilitas gel yang baik dalam formulasi. Kata Kunci: Daun Ekor Naga, Gel, Inflamasi, Air Pouch

show abstract

Uji Efek Antiinflamasi Fraksi Daun Piladang (Solenostemonscutellarioides (L.) Codd) terhadap Mencit Putih Betina

Cited by 6 publications

References 0 publications

ANTI INFLAMMATORY ACTIVITY OF SUNGKAI LEAVES (Peronema canescens JACK) ETHANOL EXTRACT IN CARRAGEENAN INDUCED MICE

ANTI INFLAMMATORY ACTIVITY OF SUNGKAI LEAVES (Peronema canescens JACK) ETHANOL EXTRACT IN CARRAGEENAN INDUCED MICE

Anti-Inflammation Activity of Ethyl Acetate Extract of Malacca Leaves (Phyllanthus emblica)

Efek Pemberian Gel Ekstrak Etanol Daun Ekor Naga (Rhaphidophora pinnata (L.f) Schott) Sebagai Antiinflamasi Metode Carrageenan-Induced Air Pouch

Contact Info

Product

Resources

About