Uji Efektivitas Sediaan Gel Ekstrak Batang Pepaya (Carica papaya L.) Sebagai Penyembuh Luka Sayat Pada Tikus Putih (Rattus novergicus).

Watung, Esterlina J.; Sambou, Christel N.; Maarisit, Wilmar

doi:10.55724/j.biofar.trop.v3i2.278

Cited by 3 publications

(5 citation statements)

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“…The analysis results are supported by previous studies that showed papaya leaves could be used as an antiseptic in the form of a gel. The preparation gel with papaya leaf extract levels starting from 10% can reduce microorganisms by up to 57% (Watung et al, 2020).…”

Section: Medical Laboratory Technology Journal |mentioning

confidence: 99%

“…Myofibroblast cells commonly found in wound contraction consist of actin and myosin equal to the contraction system in smooth muscle so that myofibroblasts can contract and elongate. Wound contraction that occurs in the late stages of wound healing looks like the changes in the shape of the wound and the reduction of the open wound area and produces a smaller wound area (Watung et al, 2020).…”

Section: Medical Laboratory Technology Journal |mentioning

confidence: 99%

“…The use of thick extracts directly on the skin is less practical and less optimal; it is necessary to make preparations that can stick to the skin surface for a long time and are occlusive so that they effectively heal wounds, namely semi-solid preparations in the form of gels. The appearance of the gel is like a solid substance that is soft and chewy, but at a certain temperature range, it can behave like a fluid (Watung et al, 2020). Previous research stated that the gel preparation of Carica papaya ethanol extract had a test of burn healing activity on white rats.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Papaya Leaf Extract Gel (Carica papaya) on Incision Wound Healing in Rattus norvegicus

Marlinawati

Nurhidayah²,

Santoso³

et al. 2022

Med.Lab.Tech.J.

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Carica papaya is one kind of herbal plant that can help the wound healing process. Scientifically, the leaves of papaya are proven to have anti-inflammatory effects. Flavonoid, alkaloid, tannin, and saponin compounds in papaya leaves have antimicrobial and antioxidant properties to accelerate the re-epithelization and cell migration needed for wound healing. This research aims to determine the effect of papaya leaf extract gel (Carica papaya) on the healing of incision wounds in Rattus norvegicus based on changes in wound morphology (signs of redness, edema, pus, granulation, moisture, and wound length). This research used female Rattus norvegicus aged 12-16 weeks weighing 180-200 grams, divided into five groups (NaCl 0,9%, povidone-iodine, papaya leaf extract gel with concentrations of 10%, 20%, and 30%). Incision wounds on the back of the rat with a length of 2 cm and depth of 1 cm. The normality test used the Shapiro-Wilk test, and the homogeneity test used the Levene test. The research data were not normally distributed nor homogeneous, so they were analyzed using the Kruskal Wallis and Mann-Whitney tests. The results showed that the extract of papaya leaves with concentrations of 10%, 20%, and 30% had significant differences in positive and negative control groups in the wound healing process with the differences in redness (p=0.038), granulation tissue (p=0.039), moistures (0,48), and wound length (p=0,049). It can be concluded that papaya leaf extract gel (Carica papaya) is effective in accelerating the healing process of incision wounds in Rattus norwegicus at concentrations of 10%, 20%, and 30%, so for further research, it is hoped that a histopathological examination can be carried out so that changes that occur in collagen, neutrophile cells, monocytes, and lymphocytes are seen.

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Section: Medical Laboratory Technology Journal |mentioning

confidence: 99%

Section: Medical Laboratory Technology Journal |mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of Papaya Leaf Extract Gel (Carica papaya) on Incision Wound Healing in Rattus norvegicus

Marlinawati

Nurhidayah²,

Santoso³

et al. 2022

Med.Lab.Tech.J.

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“…Of course, superworm can live well when given organic feed intake (van Broekhoven et al, 2015), especially feed with fibre above 5% (Li et al, 2016). Papaya stems as superworm feed are believed to provide not only fibre but also produce quality superworms, given the presence of antibacterial content in papaya stems (Handayani et al, 2020;Nirmala et al, 2022;Watung et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Superworm (Zophobas morio) breeding for papaya stem waste management

Lisanty,

Hadiyanti,

Wibowo

et al. 2023

jcse

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Boyolangu District is a famous papaya-producing area and the largest in Tulungagung Regency. The local papaya farming community is active in farming. They succeeded in producing approximately 10 tons of papaya in 2020. This number has decreased by more than half from the previous year in 2019. This is inseparable from the impact of the COVID-19 pandemic. In addition, the community complaint about a large amount of papaya stem waste after harvest. Waste management is a separate problem for farmers. Not to mention the added problem of the low price of papaya per kilogram. Therefore, a community service program aims to overcome the target community's problems with superworm (Zophobas morio) breeding education and training. The activity conducted by the team of the Faculty of Agriculture, University of Kadiri empowering the papaya farming community in Boyolangu District, Tulungagung Regency to manage papaya stem waste as an alternative feed for superworm breeding. Farmers were invited to breed superworm as their additional income and improve the standard of living of the family. This activity mainly focused on the introduction and training of superworm breeding. The activity was beneficial for the social, economic, and environmental life of the target community.

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“…Nowadays, the use of herbal therapy is increasingly popular because apart from being effective, it also tends to have a very low risk of side effects. One of the plants that is receiving great attention is the papaya plant, because various parts such as leaves, fruit, stalks, stems and roots have a number of benefits in a medicinal context (Syahruddin, 2019).…”

Section: Introductionmentioning

confidence: 99%

Carica Papaya L. With Suture Wound Healing in Mice Experimental Animals

Istiqomah,

Azizah,

Purwanti

et al. 2023

IMHSJ

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Background: Stitches are a condition in which skin tissue damage results from incisions or surgery and trauma. Carica Papaya Linn contains flavonoids which are efficacious as anti-inflammatory or antiseptic in inhibiting bacterial growth. Carica Papaya Linn is effective in repairing cells damaged by free radicals. The purpose of this study was to see the effectiveness of papaya leaf extract (Carica Papaya Linn) against stitches. Method: This research was quantitative research with a True Experimental design with the one group post-test method using the REEDA scale assessment. The population in this study were mice (Mus Musculus) which were divided into 5 groups, control group, nebacetin group, 5% test group, 10% test group and 15% test group. Research was conducted in the Lab. Medical Laboratory Technology at Muhammadiyah University of Sidoarjo and for making extracts from the Faculty of Mathematics and Natural Sciences, Surabaya State University. Data was collected and then the results were analysed using the One Way ANOVA statistical test. Result: The results of the statistical test showed a value of P = 0.000 in the 7th day group, which means there was a difference in each group of mice and the mean results showed the lowest result was 0.2 in the 15% extract which stated the best wound healing. Conclusion : The conclusion of the study was that there was an effect of giving papaya leaf extract (Carica Papaya L.) on wound healing in experimental mice.

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Uji Efektivitas Sediaan Gel Ekstrak Batang Pepaya (Carica papaya L.) Sebagai Penyembuh Luka Sayat Pada Tikus Putih (Rattus novergicus).

Cited by 3 publications

References 0 publications

Effect of Papaya Leaf Extract Gel (Carica papaya) on Incision Wound Healing in Rattus norvegicus

Effect of Papaya Leaf Extract Gel (Carica papaya) on Incision Wound Healing in Rattus norvegicus

Superworm (Zophobas morio) breeding for papaya stem waste management

Carica Papaya L. With Suture Wound Healing in Mice Experimental Animals

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