UJI TOKSISITAS AKUT EKSTRAK AIR HERBA PECUT KUDA (Stachytarpheta jamaicensis (L) VAHL) PADA MENCIT SWISS WEBSTER

Sutjiatmo, Afifah Bambang; Sukandar, Elin Yulinah; Candra, Candra; Vikasari, Suci Nar

doi:10.26874/kjif.v3i2.103

Cited by 6 publications

(6 citation statements)

References 1 publication

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“…As a conclusion, Cincalok oil can be considered affecting on nervous system because it decreased motoric and platform activities. 17 The observations of body weight showed that there were no significant body weight variations in both doses. It indicated the normal processing of carbohydrate, protein, and lipids metabolism and normal functions of vital organs in the body, which are the major targeted area of any toxic substance metabolically.…”

Section: Disscussionmentioning

confidence: 90%

Acute Oral Toxicity of Cincalok Oil in Wistar Rats

Nurbaeti

Fajriaty

Nugraha

et al. 2021

IJPST

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Cincalok is a West Kalimantan traditional fermented food that has an opportunity to be developed into supplement products as a source of omega 3 and astaxanthin. This study was designed to observe the acute toxicity of Cincalok oil in female rats for its safety profile using AOT 425 program. Cincalok oil for the acute (2000 and 5000 mg/kg) toxicity studies was administered orally according to the OECD guidelines 425. The rat’s body and organs weight were observed then signs of toxicity were assessed. LD50 was being determined at the end of the study. The result showed that a single dose of Cincalok oil at 2000 or 5000 mg/kg had no lethal effect, behavioral change, a significant change in rat’s bodyweights, or any lesion on the rat’s organs. The LD50 of Cincalok oil for oral administration was higher than 5000 mg/kg and categorized as practically non-toxic.Keywords: Acute Toxicity, Cincalok Oil, LD50.

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Section: Disscussionmentioning

confidence: 90%

Acute Oral Toxicity of Cincalok Oil in Wistar Rats

Nurbaeti

Fajriaty

Nugraha

et al. 2021

IJPST

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“…Walaupun perlakuan menghasilkan nilai yang berbeda nyata, bobot badan mencit kedua kelompok dosis tersebut masih berada pada rentang bobot normal, yaitu 18-35 g untuk mencit betina (Nugroho, 2018). Hasil penimbangan bobot badan ini sesuai dengan penelitian Sutjiatmo et al (2015) yang menunjukkan bahwa perlakuan bahan herbal pada mencit betina menyebabkan penurunan bobot badan. Hal tersebut dikarenakan bahan herbal yang digunakan berpotensi toksik pada organ mencit betina, seperti hati, ginjal, dan tuba Fallopii.…”

Section: Pembahasanunclassified

Toksisitas akut infusa daun pepaya Calina jantan (Carica papaya L.) pada mencit betina

Sari

Safika

Putra³

et al. 2023

curr. biomed.

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Pepaya (Carica papaya L) merupakan salah satu tanaman yang berpotensi sebagai obat untuk beragam penyakit. Penelitian bertujuan menguji toksisitas akut ekstrak daun pepaya Calina (IPB 9) jantan pada mencit betina dengan menentukan nilai lethal dose 50 (LD50), mengamati pengaruhnya pada organ tubuh mencit, dan menghitung konsentrasi ekstrak yang paling efektif. Penelitian menggunakan 20 ekor mencit galur DDY yang dibagi secara acak ke dalam 4 kelompok perlakuan, yaitu kelompok kontrol (pemberian akuades) dan kelompok perlakuan pemberian infusa daun pepaya Calina jantan masing-masing dengan dosis 5, 10, dan 15 g/kg BB secara per oral. Pengamatan dilakukan pada mortalitas, gejala klinis, respons fisiologis, bobot badan, dan bobot relatif organ. Nilai LD50 menunjukkan pemberian infusa daun pepaya Calina jantan pada mencit betina bersifat tidak toksik. Pemberian infusa daun pepaya Calina jantan sampai dengan dosis 15 g/kg BB tidak menimbulkan gejala klinis yang bersifat patologis, perubahan makroanatomi organ, atau kematian. Pemberian infusa tidak menunjukkan efek yang signifikan pada peningkatan atau penurunan bobot badan. Pemberian infusa daun pepaya Calina jantan dengan dosis 10 g/kg BB terbukti paling efektif dalam mempertahankan pertambahan bobot badan secara normal dan tidak bersifat toksik. Berdasarkan penelitian, pemberian infusa daun pepaya Calina jantan sampai dengan dosis 15 g/kg BB bersifat tidak toksik dan tidak memengaruhi organ tubuh mencit, dengan dosis efektif sebesar 10 g/kg BB.

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“…Toksisitas ekstrak air tanaman pecut kuda lebih besar dari 5.000 mg/kgBB sehingga keamanannya termasuk kategori senyawa yang praktis tidak toksik. 21 Pemberian ekstrak air daun pecut kuda pada dosis 100 mg/kgBB dapat mengakibatkan efek samping sehingga perlu dilakukan pengujian lebih lanjut berupa uji toksisitas subkronik.…”

Section: Pembahasanunclassified

Water Extract Influence of Stachytarpheta jamaicensis (L.) Vahl Leaves to Prevent Psoriasis Severity in Animal Model

Abdurahman

Permana²,

Mardiana³

et al. 2022

IJPST

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Psoriasis is an autoimmune disease that is characterized by the appearance of lesions on the skin. The current treatment aims to control the symptoms. The efficacy of Stachytarpheta jamaicensis (L.) Vahl’s for autoimmune rheumatoid arthritis and systemic lupus erythematosus has been tested in animal models. The aim of this research was to evaluate the effect of the water extract of S. jamaicensis leaves on psoriasis model animal (male Balb/c mice) induced topically by imiquimod. The water extract of S. jamaicensis leaves is made by boiling. The animal was divided into groups: normal, control, methotrexate 0.2 mg/kgBW, the extract (doses 25, 50 and 100 mg/kgBW). The measured parameters were the Psoriasis Area and Severity Index (PASI) score and skin histopathology. The results showed that all doses of the extract could reduce the PASI score when compared to the control group. Histological results showed that there was a decrease in keratin growth in test animals that were given the extract. Extracts at doses of 25 and 50 mg/kgBW can reduce the thickening of keratin in the epidermis of the back and ears. It can be concluded that the water extract of S. jamaicensis leaf has the most effective activity to prevent psoriasis recurrence in the dose range of 25 and 50 mg/kgBW.Keywords: Psoriasis, Stachytarpheta jamaicensis leaf water extract, PASI, keratin, imiquimod

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UJI TOKSISITAS AKUT EKSTRAK AIR HERBA PECUT KUDA (Stachytarpheta jamaicensis (L) VAHL) PADA MENCIT SWISS WEBSTER

Cited by 6 publications

References 1 publication

Acute Oral Toxicity of Cincalok Oil in Wistar Rats

Acute Oral Toxicity of Cincalok Oil in Wistar Rats

Toksisitas akut infusa daun pepaya Calina jantan (Carica papaya L.) pada mencit betina

Water Extract Influence of Stachytarpheta jamaicensis (L.) Vahl Leaves to Prevent Psoriasis Severity in Animal Model

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