UK Renal Registry 19th Annual Report: Chapter 3 Demographic and Biochemistry Profile of Kidney Transplant Recipients in the UK in 2015: National and Centre-specific Analyses

Sharples, Edward; Casula, Anna; Byrne, Catherine

doi:10.1159/000481365

Cited by 7 publications

(8 citation statements)

References 8 publications

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“…The overall prognosis of KT in South Korea was comparable to those of other developed countries [5][6][7]. However, the graft failure rate seemed relatively worse when compared to pure Asian population in the recent OPTN/SRTR annual data.…”

Section: Discussionmentioning

confidence: 63%

“…Thus, future improvements in donor allocation, donor shortage, discrepancy in accessibility to transplant, prognosis of recipients, and socioeconomic cost for transplantation are still necessary. In several countries, certain annual reports and nationwide studies described the characteristics of KT in their nations [5][6][7][10][11][12]. In South Korea, KONOS issued important annual reports regarding the characteristics of KT in the nation [4], and further information regarding detailed characteristics, prognosis, medication usage, and economic cost was warranted [13].…”

Section: Discussionmentioning

confidence: 99%

“…Recognizing the clinical and socioeconomic importance of KT, the Korean Network for Organ Sharing (KONOS) has published annual reports about the characteristics of transplantation including kidney cases [4]. However, detailed information of medication usage, prognosis, and socioeconomic cost of KT in the nation has been scarcely described, although other annual reports in various regions provided an important insight regarding the era of transplantation [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

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Characteristics of kidney transplantation recipients over time in South Korea

Park

Kim

et al. 2020

Korean J Intern Med

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Background/Aims: Detailed nationwide information regarding the recent status and time trends of kidney transplantation (KT) in South Korea is limited. Methods: We performed a nationwide, population-based cohort study using the national claims database of Korea. We included KT recipients from 2008 to 2016, and their demographic and clinical characteristics were collected. The prognostic outcome was graft failure consisted of patient death and death-censored graft failure (DCGF). Results: We studied 14,601 KT recipients with median follow-up duration of 3.96 years. The median age at the time of transplantation consistently increased from the past, and proportion of underlying diabetes mellitus prominently increased, reaching 35.6% in 2016. The preemptive KT accounted for approximately 30% of the total transplantation cases. The recipients showed a 10-year cumulative graft survival rate of 71.8%, consisting of 10-year DCGF free survival of 77.6% and patient survival of 92.8%. Age ≥ 20 and < 30 years, age ≥ 70 years, underlying history of diabetes, non-preemptive transplantation, and poor compliance on tacrolimus and mycophenolic acid were the significant risk factors associated with worse DCGF outcome. The economic cost of KT showed prominently increasing trends, reaching a total insured fee of > 60,000,000$ in 2016. However, the expansion was mainly burdened by the national insurance service but not by the patients. Conclusions: In South Korea, the number of kidney transplantation in elderly or in patients with comorbidities has been increasing. Complex clinical factors were associated with medication compliance and patient prognosis.

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Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Characteristics of kidney transplantation recipients over time in South Korea

Park

Kim

et al. 2020

Korean J Intern Med

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“…Allogeneic renal transplantation is the treatment of choice for end-stage kidney disease, offering superior outcomes in terms of morbidity and mortality when compared to dialysis [1,2]. However, kidney transplants do not survive the lifespan of most recipients [3] and approximately 840 patients return to dialysis each year in the United Kingdom (UK) [4]. This makes allograft failure the fifth most common reason for people to start dialysis in the UK [5], while in the United States (US), allograft failure is the fourth most common reason [6].…”

Section: Introductionmentioning

confidence: 99%

Causes of renal allograft failure in the UK: trends in UK Renal Registry and National Health Service Blood and Transplant data from 2000 to 2013

Burton

Perisanidou

Steenkamp

et al. 2018

Nephrology Dialysis Transplantation

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Background. Improvement in long-term renal allograft survival is impeded by incomplete or erroneous coding of causes of allograft loss. This study reports 13-year trends in causes of graft failure across the UK. Methods. National Health Service Blood and Transplant (NHSBT) and UK Renal Registry data were linked to describe UK kidney patients transplanted 2000-2013. NHSBT graft failure categories were used, with 'other' recoded when free text was available. Adjusted analyses examined the influence of age, ethnicity and donor type on causes of graft failure. Results. In 22,730 recipients, 5,389 (23.7%) grafts failed within a median follow-up of five years. The two most frequent causes were death with a functioning graft (40.8%) and alloimmune pathology (25.0%). Graft survival was higher in recipients who were younger (mean 47.3 vs. 50.7 years), received a pre-emptive transplant (20.2% vs. 10.4%), spent less time on dialysis (median 1.6 vs. 2.4 years) and received a living donor transplant (36.3% vs. 22.2%), with no differences by sex, ethnicity or human leukocyte antigen mismatch. Allograft failure within two years of transplantation fell from 12.5% (2000-2004) to 9.8% (2009-2013). Surgical and alloimmune related failures decreased over time while death with a functioning graft became more common. Age, ethnicity and donor type were factors in recurrent primary disease and alloimmune pathology. Conclusions. Since 2000 there have been reductions in surgical and alloimmune graft failures in the UK. However, graft failure codes need to be revised if they are to remain useful and effective in epidemiological and quality improvement trials.

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“…Cardiovascular disease affects two-thirds of older persons with CKD [ 33 , 34 ]—the majority with atherosclerotic heart disease—and accounts for 39% of deaths in patients on dialysis [ 34 ] and at least 22% of deaths in those with a kidney transplant [ 33 ]. Around 30% of adults aged over 40 years in the US report taking low-dose aspirin for primary or secondary prevention of cardiovascular disease [ 35 ].…”

Section: Introductionmentioning

confidence: 99%

Renal biopsy: it is time for pragmatism and consensus

Lees

McQuarrie

Mackinnon

2018

Clinical Kidney Journal

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To obtain truly informed consent, we must be able to advise our patients accurately about the relative risk and benefit of any treatment plan. Percutaneous renal biopsy remains the gold standard investigation in the evaluation of intrinsic renal disease. There have been significant improvements in practice over the past decades with regards to percutaneous renal biopsy. Across centres, we appear now to have reached agreement on many aspects of this procedure, such as the need for blood pressure control, avoidance of coagulopathy, use of spring-loaded needles under direct imaging guidance and a need to monitor for complications. The authors from Rush University Medical Centre provide reassurance that renal biopsy in the modern era remains a safe procedure with a low rate of significant bleeding. There remain areas of divergence in practice that may have unintended and deleterious consequences: administration of desmopressin and discontinuation of aspirin, for example, both carry a risk of thrombosis. It is our opinion that it is time to reach consensus on our interpretation of the available data and to draw up guidelines to standardize our biopsy practice internationally.

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UK Renal Registry 19th Annual Report: Chapter 3 Demographic and Biochemistry Profile of Kidney Transplant Recipients in the UK in 2015: National and Centre-specific Analyses

Cited by 7 publications

References 8 publications

Characteristics of kidney transplantation recipients over time in South Korea

Characteristics of kidney transplantation recipients over time in South Korea

Causes of renal allograft failure in the UK: trends in UK Renal Registry and National Health Service Blood and Transplant data from 2000 to 2013

Renal biopsy: it is time for pragmatism and consensus

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