Ulcer Healing and Gastroprotective Activity of Methanolic Extracts of Hyoscyamus Albus and Umbilicus Rupestris Leaves against Gastric Injury Caused by Ethanol in Rats

Yahia, Mouloud; Benhouda, Afaf; Benbia, S.; Khadraoui, Hachani

doi:10.21767/2393-8854.10008

Cited by 5 publications

(3 citation statements)

References 8 publications

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“…Flavonoids, phenols, tannins, alkaloids, saponins, and terpenoids were found in the phytochemical analysis of the C. paniculatum extract and fractions. These phytoconstituents, particularly flavonoids and tannins, were previously established to be among the possible cytoprotective agents involved in reducing gastric ulcer [30,31]. The presence of these phytochemicals in the extract and fractions of C. paniculatum may account for its use in the treatment of ulcers.…”

Section: Discussionmentioning

confidence: 99%

Gastroprotective effects of Combretum paniculatum (Combretaceae) leaf extract and fractions on absolute ethanol-induced gastric ulcer in rats

et al. 2022

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Background Combretum paniculatum (Combretaceae) Vent. is commonly used in traditional medicine to treat ulcers and gastrointestinal disorders, including distended spleens and the liver. This study investigated the gastroprotective effects of C. paniculatum leaf extract and its fractions on absolute ethanol-induced gastric ulcers in rats and explored their effects on endogenous antioxidant (SOD, MDA, GSH, and Catalase) levels. Butanol, n-hexane, and ethyl acetate extracts (100 and 200 mg/kg), omeprazole (20 mg/kg), and control (3% Tween 80) were administered orally. Results The methanolic extract and fractions of C. paniculatum exhibited varying degrees of ulcer protection. MECP exhibited significant (P < 0.05) ulcer protection (55.56%) at 200 mg/kg; at 100 and 200 mg/kg, HFCP induced considerable (P < 0.01 & 0.001) ulcer reduction (64.44% and 80.00%), respectively; EAFCP offered substantial (P < 0.05) ulcer reduction (57.78%) at 200 mg/kg, whereas BFCP produced significant (P < 0.01) ulcer protection (73.33% and 68.89%) at 100 and 200 mg/kg against absolute ethanol-induced ulcer. MDA levels were substantially reduced after pretreatment with the extract and fractions, whereas SOD, GSH, and catalase levels were significantly enhanced. Conclusion These findings suggest that C. paniculatum leaf extract and fractions possess gastroprotective actions against ethanol-induced ulcers and exert these effects through antioxidant mechanisms. Therefore, the traditional use of C. paniculatum leaves in the treatment of ulcers is justified.

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Section: Discussionmentioning

confidence: 99%

Gastroprotective effects of Combretum paniculatum (Combretaceae) leaf extract and fractions on absolute ethanol-induced gastric ulcer in rats

et al. 2022

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“…This study is based on our phytochemical screening of this extract which revealed the presence of flavonoids, tannins, triterpenoids and saponin. These phytoconstituents, particularly flavonoids and tannins, were previously established to be among the possible cytoprotective agents involved in reducing gastric ulcer [36, 37].…”

Section: Discussionmentioning

confidence: 99%

Antiulcerogenic effect of Cuphea ignea extract against ethanol-induced gastric ulcer in rats

Mousa

El-Sammad

Hassan

et al. 2019

BMC Complement Altern Med

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BackgroundCuphea ignea is one of the herbal resources belonging to Lythraceae family. Some species of this family have been used traditionally in South and Central America’s folk medicine for treating stomach disorders. Therefore, the present study was performed to evaluate the gastropreventive effect of aqueous ethanolic extract of C. ignea aerial parts on ethanol-induced gastric ulcer.MethodsGastric ulcers were induced in Sprague Dawley rats using one oral dose of absolute ethanol (1.5 mL/rat). The C. ignea aerial parts extract at doses of 250 and 500 mg/kg body weight and ranitidine (a reference drug) at a dose of 30 mg/kg body weight were orally administrated daily for 7 days before ulcer induction. One hour after ethanol administration blood samples were collected and then stomachs of sacrificed rats were subjected to biochemical, macroscopic and microscopic studies.ResultsOral administration of C. ignea extract significantly attenuated gastric ulcer as revealed by significant reduction in the gastric ulcer index and volume of gastric juice while significantly increased preventive percentage, gastric pH value and pepsin activity. Pre-treatment of C. ignea extract markedly improved the serum level of TNF-α, the gastric MPO activity and NO content. Furthermore, C. ignea pre-treatment significantly increased the gastric levels of enzymatic and non- enzymatic antioxidants namely CAT, SOD, GSH-Px, and GSH with concomitant reduction in MDA level compared with those in the ethanol group. These results were further supported by histopathological findings which revealed the curing effect of C. ignea on the hemorrhagic shock induced by ethanol toxicity.ConclusionsC. ignea extract showed a potential gastroprotective effect on ethanol-induced gastric ulcer, and its effect may be mediated through suppression of oxidative stress and gastric inflammation.

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“…The percentage protection offered by 200 and 400 mg/kg b. w. of MELA were 78.88 and 82.40 %, respectively, while CIM gave 79.83 % to rats. These observations could be due to the presence of the phenolic and flavonoids contents in the extract as these phytochemicals have been reported to possess anti-ulcerative properties [35]. Biochemical analyses of gastric secretions (for pH, gastric volume, bicarbonate and pepsin activity) and mucosal integrity of stomach are usually employed to ascertain its status following exposure to pharmacological agents [36].…”

Section: Effects Of Mela and Cim On Ulcerogenic Parameters In Ethanol...mentioning

confidence: 99%

Cytoprotective Effect of Methanol Extract of Laportea aestuans on Acidified Ethanol-induced Gastric Ulcer in Male Wistar Rats

Tijani

Temitayo²,

Farombi³

2022

Trends Sci

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Laportea aestuans (Urticaceae) plant is widely distributed in tropical rain forests and used as remedial agent for various diseases in Nigeria by herbal practitioners. Ethanol consumption is one of the common causes of gastric ulcer due to excessive generation of reactive oxygen species and erosion of gastric mucosal layer. This study investigated the cytoprotective effect of pretreatment with methanol extract of Laportea aestuans (MELA) for 7 days on ethanol-induced gastric ulcer in male Wistar rats using cimetidine as a standard drug. Ulcerogenic parameters, oxidative damage, inflammatory and apoptotic markers were evaluated. MELA showed a significant dose-dependent (p < 0.01) decrease in ulcer score (US), ulcer index (UI) and peptic activity with an increase in mucus content and percentage inhibition compared to the ethanol group. Activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), Glutathione S-transferase (GST) and level of reduced glutathione (GSH) were also increased with concomitant decrease in malondialdehyde (MDA) level in MELA treated rats. Serum levels of tumor necrosis factor-alpha (TNF-α), interleukin-1β (IL-1β) and activities of cytochrome c (Cyt c), caspases-3 and -9 (CASPS-3 and -9) were also reduced by administration of MELA. Taking together, this study shows that MELA protected the gastric mucosal against the assault induced by ethanol via upregulation of the antioxidant system, and downregulation of inflammatory and apoptotic processes. HIGHLIGHTS Oral administration of ethanol to Wistar rats induced gastric ulceration Oral administration of ethanol to Wistar rats caused ulcer by generation of ROS, inflammation and induce apoptosis Pretreatment of rats with methanol extract of Laportea aestuans (MELA) preserved the gastric mucosal integrityby boosting antioxidant defence system and inhibiting inflammatory and apoptotic processes GRAPHICAL ABSTRACT

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Ulcer Healing and Gastroprotective Activity of Methanolic Extracts of Hyoscyamus Albus and Umbilicus Rupestris Leaves against Gastric Injury Caused by Ethanol in Rats

Cited by 5 publications

References 8 publications

Gastroprotective effects of Combretum paniculatum (Combretaceae) leaf extract and fractions on absolute ethanol-induced gastric ulcer in rats

Gastroprotective effects of Combretum paniculatum (Combretaceae) leaf extract and fractions on absolute ethanol-induced gastric ulcer in rats

Antiulcerogenic effect of Cuphea ignea extract against ethanol-induced gastric ulcer in rats

Cytoprotective Effect of Methanol Extract of Laportea aestuans on Acidified Ethanol-induced Gastric Ulcer in Male Wistar Rats

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