Ulcerating Tumor of Tonsil and Neck Mass as Occurrence of Acute Myelocytic Leukemia

Zapf, Burger; Carpenter, Robert J.; Snyder, G. Gordon

doi:10.1177/019459988108900410

Cited by 5 publications

(3 citation statements)

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“…AML occurrence and progression depend upon oxidative phosphorylation and amino sugar and nucleotide sugar metabolism pathways. 17 , 18 …”

Section: Discussionmentioning

confidence: 99%

Downregulation of PDIA3 inhibits proliferation and invasion of human acute myeloid leukemia cells

Ye¹,

Fu²,

Dou³

et al. 2018

OTT

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IntroductionAcute myeloid leukemia (AML) is a common malignancy of the hematopoietic system. In bone marrow samples of AML patients, PDIA3 expression was higher than that in the samples of healthy controls. We aimed at exploring the effect of PDIA3 siRNA on proliferation, apoptosis, migration, and invasion of AML HL-60 and HEL cells.Materials and methodsRT-PCR was performed to identify PDIA3 expression. Cell proliferation was assessed by MTT. Flow cytometry analysis and transwell were used to detect cell apoptosis, migration and invasion. Gene set enrich-ment analysis (GSEA) was employed to explore the PDIA 3-associated pathways in AML. Western blotting was used for protein expression detection.ResultsPDIA3 siRNA significantly inhibited the proliferation of AML cells at 24 and 48 h. PDIA3 siRNA notably enhanced the percentage of apoptotic cells. The migration and invasion abilities of HL-60 and HEL cells in the PDIA3 siRNA group were significantly suppressed compared with those in the control and siNC groups. GSEA of the Cancer Genome Atlas dataset showed that Kyoto Encyclopedia of Genes and Genomes oxidative phosphorylation and amino sugar and nucleotide sugar metabolism pathways could be correlated with PDIA3 expression; this was further confirmed in AML cells by Western blotting. MAPK signaling was also blocked by PDIA3 siRNA.ConclusionPDIA3 siRNA effectively enhanced apoptosis, and suppressed proliferation, invasion, and migration of AML cells by regulating oxidative phosphorylation and amino sugar and nucleotide sugar metabolism pathways, and MAPK signaling, which can provide novel therapeutic targets for AML.

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“…AML occurrence and progression depend upon oxidative phosphorylation and amino sugar and nucleotide sugar metabolism pathways. 17 , 18 …”

Section: Discussionmentioning

confidence: 99%

Downregulation of PDIA3 inhibits proliferation and invasion of human acute myeloid leukemia cells

Ye¹,

Fu²,

Dou³

et al. 2018

OTT

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“…Lymphadenopathy and tonsillar involvement are rare in AML [23][24][25], and it is controversial whether EML in AML generally confers a poor prognosis [26]. It remains to be shown whether the observed occurrence of cervicotonsillar EML in inv(16)/t(16;16)-positive AML has clinical relevance.…”

Section: Discussionmentioning

confidence: 99%

Acute myeloid leukemia with inv(16)(p13q22): Involvement of cervical lymph nodes and tonsils is common and may be a negative prognostic sign

et al. 2002

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“…nasopharyngeal cancer) and less severe (e.g. high blood pressure) disorders, and therefore has the potential to induce appraisals of danger and opportunity (Schoenberg & Drew, 2002;Zapf et al, 1981). In terms of message content, the conversations were developed based on the first author's real-life experiences of consulting with doctors about frequent nosebleeds on two existing medical consultation websites (i.e.…”

Section: Appraisal Of Opportunity Positive Affective and Behavioural Responsesmentioning

confidence: 99%

Vague Language in Online Medical Consultation

Smit

2021

EJHC

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Online medical consultation has become increasingly popular, while little is known about what features of such service can impact users’ emotions and behaviours. This study looked into the language features of online text-based medical consultation. Specifically, the aim of this paper was to examine the effects of vague language (i.e., non-specific, imprecise language) on health-related uncertainty, and its affective and behavioural consequences, while considering individual differences in regulatory focus. A between-subject (vague language vs. precise language vs. control condition) web-based experiment was conducted (N = 249), where participants in the experimental groups read virtual doctor-patient conversations where the doctor used either vague or precise language. Results showed that vague language induced more uncertainty than precise language (p = .010); such uncertainty was appraised as a danger (r = .18, p = .004) but not an opportunity (r = .01, p = .932), and subsequently led to negative emotions (r = .45, p < .001). No effects were found on behavioural outcomes, and there was no moderation from regulatory focus. The results suggest that online healthcare providers should refrain from using vague language in communication with patients to avoid eliciting uncertainty and subsequent negative feelings. Future research is needed to further examine the behavioural effects of uncertainty and explore factors that could foster the appraisal of opportunity.

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Ulcerating Tumor of Tonsil and Neck Mass as Occurrence of Acute Myelocytic Leukemia

Cited by 5 publications

References 2 publications

Downregulation of PDIA3 inhibits proliferation and invasion of human acute myeloid leukemia cells

Downregulation of PDIA3 inhibits proliferation and invasion of human acute myeloid leukemia cells

Acute myeloid leukemia with inv(16)(p13q22): Involvement of cervical lymph nodes and tonsils is common and may be a negative prognostic sign

Vague Language in Online Medical Consultation

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