Ulceration of the cornea in rheumatoid arthritis.

Jayson, M. I. V.; Easty, D L

doi:10.1136/ard.36.5.428

Cited by 44 publications

(17 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In RA, sterile corneal ulceration can occur in either the central or peripheral cornea with a paucity of ocular symptoms (1,2). Progression to corneal perforation and visual loss can be relatively asymptomatic or can be associated with anterior uveitis and pain ( I ,2).…”

Section: )mentioning

confidence: 99%

Rheumatoid arthritis and sterile corneal ulceration

Michels

Cobo

Caldwell

et al. 1984

Arthritis & Rheumatism

View full text Add to dashboard Cite

Tissue immune effector cells and epithelial surface antigens present in eye tissue of rheumatoid arthritis (RA) patients with sterile corneal ulceration were studied using a large panel of monoclonal antibodies. During periods of active corneal ulceration, conjunctivae and corneas of all RA patients studied contained numerous immune-associated (Ia) antigen-positive tissue macrophages. In 4 of 6 patients, conjunctival or corneal T cell infiltrations were present. In 2 patients, a T cell vasculitis was seen in conjunctival tissue. Conjunctival epithelial cells of all 6 RA patients expressed Ia antigens during active corneal ulceration. These data provide evidence for immune-mediated mechanisms in the pathophysiology of corneal ulceration in RA. Moreover, the expression of Ia antigens by conjunctival epithelial cells may be a useful indicator of disease activity in RA patients with sterile corneal ulceration.The pathophysiologic events in rheumatoid arthritis (RA) leading to corneal ulceration and corneal stromal loss in the absencc of scleritis are unknown (I-

show abstract

Section: )mentioning

confidence: 99%

Rheumatoid arthritis and sterile corneal ulceration

Michels

Cobo

Caldwell

et al. 1984

Arthritis & Rheumatism

View full text Add to dashboard Cite

show abstract

“…In 1 of those cases of vasculitis there was also marginal melting of the cornea. In patients with corneal melting, described by Jayson and Easty [9], there was a wide range of expressions of rheumatoid disease, but the arthritis was inactive without systemic man ifestations and with negative tests for rheu matoid factor. In this respect our patient was similar.…”

Section: Discussionmentioning

confidence: 99%

Light and Electron Microscopical Study of the Conjunctiva in Sicca Syndrome

Meyer¹,

Y²,

Schechner³

et al. 1985

Ophthalmologica

View full text Add to dashboard Cite

Conjunctival biopsies of 11 patients with sicca syndrome were studied under light and transmission electron microscopy. The notable findings were vasculitis of the conjunctival vessels. There were severe changes in the microvilli, namely a loss of microvilli and decrease in their height, measuring approximately 1,000–2,000 A, in comparison with microvilli of the control conjunctiva, measuring 4,000 Å in height. There was no branching yet or fusion of microvilli.

show abstract

“…The common ocular complications of rheumatoid arthritis are keratoconjunctivitis, anterior uveitis, episcleritis, necrotising nodular scleritis and scleromalacia perforans [ 1 ]. Rare ocular lesions of this disease S. C. Reddy Sarojini Devi Eye Hospital and Institute of Ophthalmology, Hyderabad, India U. R. K. Rao Department of Medicine, Nizam's Institute of Medical Sciences, Hyderabad, India S. C. Reddy (~) Department of Ophthalmology, School of Medical Sciences, University Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia reported so far are rheumatoid nodules of the upper lid [2], granular opacities with peripheral vascularisation of the corneal stroma [3], marginal furrows (ulceration) of the cornea [4], peripheral ulceration of the cornea [5], sclerosing keratitis, acute stromal keratitis, corneal guttering (peripheral corneal thinning all around the limbus) or contactlens cornea, marginal keratitis, keratolysis, descemetocoele (thinning of the cornea with bulging of Descemet's membrane) or corneal perforation [6,7], corneomalacia perforans [8], choroidal nodules with secondary retinal detachment [9], cotton wool spots [10], retinal vasculitis [ 1 1, 12], venous stasis retinopathy secondary to polyclonal gammopathy [13], orbital apex syndrome resulting from orbital rheumatoid nodules [14], cranial nerve palsies and geniculocortical blindness [15], and Brown's syndrome with diplopia on upward inward gaze (looking steadily in an upward and inward direction for a period of time) caused by tenovaginitis of the superior oblique tendon [16].…”

Section: Introductionmentioning

confidence: 99%

Ocular complications of adult rheumatoid arthritis

Reddy

Rao

1996

Rheumatol Int

View full text Add to dashboard Cite

In a prospective study of 325 patients with adult rheumatoid arthritis, ocular complications were seen in 73 patients (22.4%). Keratoconjunctivitis sicca was the most common ocular lesion. Other lesions were episcleritis, scleritis, marginal thinning of the cornea with keratolysis, stromal corneal opacities with peripheral vascularisation, and iridocyclitis. The mean duration of the arthritis and the mean duration of seropositivity were found to be significantly higher in patients with ocular complications. Physicians should include ophthalmic examination as a routine in their protocol for patients with rheumatoid arthritis to facilitate early diagnosis and treatment of ocular complications.

show abstract

Ulceration of the cornea in rheumatoid arthritis.

Cited by 44 publications

References 13 publications

Rheumatoid arthritis and sterile corneal ulceration

Rheumatoid arthritis and sterile corneal ulceration

Light and Electron Microscopical Study of the Conjunctiva in Sicca Syndrome

Ocular complications of adult rheumatoid arthritis

Contact Info

Product

Resources

About