Ulcerative Colitis

Intestinal Microbiota and Perspectives of the Use of Meta-Analysis for Comparison of Ulcerative Colitis Studies

“…The diagnosis of UC is based on clinical examination, followed by a combination of biochemical, endoscopic, radiological, histological, or nuclear medicine tests. Endoscopy with histology remains the diagnostic standard of common practice [ 1 ]. To date, there is no effective treatment to ensure complete recovery of patients with UC, pharmacotherapy, and other procedures only lead to suppression of symptoms and increase the quality of life of the patient [ 5 ].…”

“…It is currently estimated that IBD affects up to 1.4 million people in the United States and 2.2 million in Europe. Gender differences have been observed in patients with a slight predominance of men [ 1 ]. Epidemiological studies have shown a north-south gradient with a higher incidence of UC in the Scandinavian countries and a lower one in the Mediterranean.…”

“…There was also an increase in the number of newly diagnosed cases from the number of newly diagnosed cases in the monitored period 1700 to 2500. The number of deaths with the main diagnosis of UC in the Czech Republic varies from 26 to 50 cases during each year [ 1 ].…”

“…Ulcerative colitis (UC) is one of the chronic inflammatory diseases of the gastrointestinal tract [ 1 , 2 ]. Its etiology has not yet been fully elucidated [ 3 , 4 , 5 ].…”

“…A low number of protective bacteria that produce short-chain fatty acids can lead to increased mucosal permeability. Conversely, enormous concentrations of some bacteria can increase the production of toxic metabolites that increase mucosal permeability and block butyrate metabolism [ 1 ]. The large intestine is populated by a specialized group of predominantly gram-negative anaerobes, known as sulfate-reducing bacteria (SRB) [ 7 , 11 , 12 , 13 , 14 , 15 , 16 ].…”