Ulcerative colitis-specific delivery of keratinocyte growth factor by neutrophils-simulated liposomes facilitates the morphologic and functional recovery of the damaged colon through alleviating the inflammation

Zhao, Ying‐Zheng; ZhuGe, De‐Li; Tong, Meng-Qi; Lin, Meng-Ting; Zheng, Yawen; Jiang, Xue; Yang, Wai-Geng; Yao, Qing; Xiang, Qi; Li, Xiaokun; Xu, He‐Lin

doi:10.1016/j.jconrel.2019.02.034

Cited by 52 publications

(29 citation statements)

References 36 publications

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“…It was reported that the MPO activity also increased in intestinal mucosal lesions of patients with inflammatory bowel disease (IBD), , which can cause a great danger if not diagnosed in time. To further demonstrate the practicability of FD-301 in biomedicine, we constructed a mouse model of ulcerative colitis (UC) to verify the potential of FD-301 for imaging the MPO activity in UC mice. , As shown in Figure a,b, the UC mice had significantly lower body weights, bloody stools, and shorter colons compared with healthy mice, indicating that the UC model was constructed successfully. However, the symptoms significantly improved after treatment with the inhibitor 5-aminosalicylic acid (5-ASA) after 8-day inflammation.…”

Section: Resultsmentioning

confidence: 99%

Detecting Basal Myeloperoxidase Activity in Living Systems with a Near-Infrared Emissive “Turn-On” Probe

et al. 2020

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Detecting myeloperoxidase (MPO) activity in living organisms is important because MPO contributes to the pathogenesis of many diseases such as rheumatoid arthritis and other inflammatory diseases, artherosclerosis, neurodegenerative disease, and some cancers. However, rapid and effective methods for the detection of basal MPO activity in living systems have not yet been reported. Herein, we report a near-infrared (NIR) emissive “turn-on” probe FD-301 that can specifically bind to MPO and accurately measure MPO activity in living cells and in vivo via a rapid response to initial hypochlorous acid (HOCl), produced by MPO. Notably, FD-301 could detect the basal level of MPO activity in human promyelocytic leukemia cells (HL-60) and could discriminate between MPO high-expression and low-expression cells. Furthermore, FD-301 was successfully applied to in vivo imaging of MPO in MPO-dependent diseases, such as arthritis and inflammatory bowel disease.

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Section: Resultsmentioning

confidence: 99%

Detecting Basal Myeloperoxidase Activity in Living Systems with a Near-Infrared Emissive “Turn-On” Probe

et al. 2020

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“…Zhao and their coworkers, in order to treat ulcerative colitis, which is a gastrointestinal (GI) inflammatory condition exaggerating the risk of GI cancers, first filled liposomes with keratinocyte growth factor (KGF) ( Figure ). [ 164 ] Next, they employed lipopolysaccharides to activate neutrophils in mice and then isolated activated neutrophils’ membranes in the form of vesicles. The incorporation of KGF‐loaded liposomes with activated neutrophil liposomes resulted in a structure named neutrophil‐like liposome (KGF‐Neus).…”

Section: Mechanisms Involved In Tumor Targeting By Leukocytesmentioning

confidence: 99%

Immune Cell Membrane‐Coated Biomimetic Nanoparticles for Targeted Cancer Therapy

Oroojalian

Beygi

Baradaran

et al. 2021

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Cancer is one of the preeminent causes of morbidity and mortality across the world, with a remarkable burden and strain on individuals and communities. [1] Several conventional and novel modalities have been employed in recent decades to overcome therapeutic challenges of cancer, depending on the Nanotechnology has provided great opportunities for managing neoplastic conditions at various levels, from preventive and diagnostic to therapeutic fields. However, when it comes to clinical application, nanoparticles (NPs) have some limitations in terms of biological stability, poor targeting, and rapid clearance from the body. Therefore, biomimetic approaches, utilizing immune cell membranes, are proposed to solve these issues. For example, macrophage or neutrophil cell membrane coated NPs are developed with the ability to interact with tumor tissue to suppress cancer progression and metastasis. The functionality of these particles largely depends on the surface proteins of the immune cells and their preserved function during membrane extraction and coating process on the NPs. Proteins on the outer surface of immune cells can render a wide range of activities to the NPs, including prolonged blood circulation, remarkable competency in recognizing antigens for enhanced targeting, better cellular interactions, gradual drug release, and reduced toxicity in vivo. In this review, nano-based systems coated with immune cells-derived membranous layers, their detailed production process, and the applicability of these biomimetic systems in cancer treatment are discussed. In addition, future perspectives and challenges for their clinical translation are also presented.

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“…For instance, Zhao et al designed a neutrophil-like liposome called KGF-Neus for the precise treatment of ulcerative colitis (UC). 29 Keratinocyte growth factor (KGF), a polypeptide with 208 amino acids, has been reported to show efficacy in the treatment of UC. 76 However, there are some limitations that impede the efficient application of KGF, such as short half-life with rapid clearance, unspecific distribution and poor stability.…”

Section: Organic Nanomaterials In Neutrophil-based Drug Delivery Systemsmentioning

confidence: 99%

Combining nanotechnology with the multifunctional roles of neutrophils against cancer and inflammatory disease

Tang

Yin

et al. 2022

Nanoscale

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Ulcerative colitis-specific delivery of keratinocyte growth factor by neutrophils-simulated liposomes facilitates the morphologic and functional recovery of the damaged colon through alleviating the inflammation

Cited by 52 publications

References 36 publications

Detecting Basal Myeloperoxidase Activity in Living Systems with a Near-Infrared Emissive “Turn-On” Probe

Detecting Basal Myeloperoxidase Activity in Living Systems with a Near-Infrared Emissive “Turn-On” Probe

Immune Cell Membrane‐Coated Biomimetic Nanoparticles for Targeted Cancer Therapy

Combining nanotechnology with the multifunctional roles of neutrophils against cancer and inflammatory disease

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