Ulcus vulvae acutum, a rare diagnosis to keep in mind

Reactive nonsexually related acute genital ulcers: Review of cases evaluated at Mayo Clinic

“…RNSRAGU preferentially affects adolescent girls. [12][13][14] Most affected patients were believed to be virginal, a characteristic that has been reported previously. 3,4,8,11,12,[14][15][16][17] We found an average age of onset of 11.5 years, similar to the findings of a previous study 15 and considerably younger than those of another.…”

“…9,10,12, 13 We found that most lesions were shallow ulcers or erosions with a clean or fibrinous base (ie, aphthae), although 3 patients developed necrotic ulcers, a complication described previously. 6,8 Taylor et al 10 noted a purple-red margin around the ulcers of several patients with RNSRAGU; this finding was not documented in the medical records or identified in the photographs of patients in our study.…”

“…Patients with moderately severe RNSRAGU (ie, pain tolerable but uncomfortable, ulceration without necrosis) may benefit from application of a class 1 or 2 topical corticosteroid (eg, clobetasol propionate or fluocinonide ointments, respectively), oral nonsteroidal anti-inflammatory drugs, and local anesthetics (eg, lidocaine jelly) to hasten resolution of associated inflammation and pain. 12,13 Despite the theoretical risk of exacerbating a recent or current infection, systemic corticosteroids may be required in patients with severely painful, multiple, or necrotic ulcers. In cases associated with ulcer necrosis, systemic antibiotics may be indicated on the basis of culture of the exudate and antimicrobial sensitivity data.…”

Vulvar ulcers: a differential diagnosis between Behçet’s disease and Lipschütz ulcus

“…More recently, similar ulcerations were found in human immunodeficiency viruspositive women, and there is also one report where Salmonella paratyphi may have been involved [1][2][3]. Most publications, however, are reported as single sporadic cases [4][5][6][7].…”

Ulcus vulvae acutum Lipschütz in two young female patients

“…The cause of this nonherpetic acute genital ulcer is still unknown, although during the 20th century several infectious agents, including EBV [3,[9][10][11][12][13], CMV [14], influenza virus [15], salmonella [16] and toxoplasmosis have been associated with the disease. We report two cases occurring in young women.…”