Ultimobranchial Origin of Calcitonin. Hypocalcemic Effect of Extracts From Chicken Glands

Copp, D. Harold; Cockcroft, Donald W.; Kueh, Y K

doi:10.1139/y67-127

Cited by 71 publications

(18 citation statements)

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“…In non-mammalian vertebrates, alternative splicing was also demonstrated generating two distinct transcripts for CT and CGRP, such as in the chicken, salmon and fugu [8,9,10]. In these groups, CT is synthesized in one organ, the ultimobranchial body [11], whereas CGRP is present in many tissues [3,12,13,14]. Analysis of the different peptide sequences in vertebrates suggests that CGRP is under stronger evolutionary control than CT.…”

Section: Introductionmentioning

confidence: 99%

Evidence for the Presence of Molecules Related to the Neuropeptide CGRP in Two Cephalopods, Sepia officinalis and Nautilus macromphalus: Comparison with Its Target Organ Distribution

Lafont¹,

Dufour²,

Fouchereau-Péron³

2006

Neuroendocrinology

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Calcitonin gene-related peptide (CGRP) is a neuropeptide mainly involved in brain and cardiovascular functions in mammals. We investigated its presence and potential roles in two cephalopods, Sepia officinalis and Nautilus macromphalus. CGRP-like, but not calcitonin (CT)-like, molecules were detected by specific radioimmuno- and radioreceptor assays in the brain, optic lobes, branchial heart or afferent branchial vein and kidney. Gel exclusion chromatography of cephalopod brain extracts, followed by SDS-PAGE, indicated that CGRP-like molecules had a molecular weight of around 3 kDa, close to that of human CGRP. The distribution of CGRP target organs was characterized by binding studies in cuttlefish. Specific CGRP binding sites were detected in the brain, optic lobes, and kidney, indicating potential autocrine/paracrine roles of CGRP. Specific CGRP binding sites were also detected in the gills and shell sac that do not contain the peptide itself, indicating potential endocrine roles of CGRP. Accordingly, high circulating levels of CGRP-like molecules were detected in hemolymph of both cuttlefish and nautilus, unlike the situation in mammals. CGRP binding sites were further characterized in the cuttlefish gills by the Scatchard method. Our study indicates that the brain neurotransmitter role of CGRP could represent an ancient role in metazoa, already present in cephalopods and conserved among vertebrates. In contrast, the endocrine role of CGRP, which was suggested in cephalopods and also present in teleosts, may have been lost during the evolution of the tetrapod lineage. Our data support the hypothesis that CGRP represents the ancestral molecule of the CT/CGRP family appeared in metazoa before the vertebrate emergence.

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Section: Introductionmentioning

confidence: 99%

Evidence for the Presence of Molecules Related to the Neuropeptide CGRP in Two Cephalopods, Sepia officinalis and Nautilus macromphalus: Comparison with Its Target Organ Distribution

Lafont¹,

Dufour²,

Fouchereau-Péron³

2006

Neuroendocrinology

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“…The thyroid parafollicular cell or C-cell is known to be the cell of origin of CT within the thyroid (2,12). Embryonically the C-cells originate in the ultimobranchial body which occurs in all vertebrate species (17).…”

Section: Introductionmentioning

confidence: 99%

Calcitonin Distribution within Pig, Sheep and Cow Thyroid

Pento¹

1978

Horm Res

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The distribution of calcitonin within the pig, sheep and cow thyroid was examined by measuring the concentration of the hormone in serial sagittal and transverse 5-mm sections of whole thyroids. It was observed that calcitonin in the pig thyroid was concentrated in the anterior to right lateral parts of the thyroid. Calcitonin was localized in the central region of the sheep thyroid with a relatively lower concentration in the peripheral parts of the gland. In the cow thyroid a uniform distribution of calcitonin was observed. The results of this study indicate a species specific and characteristic distribution of calcitonin within the thyroid of the pig, sheep and cow.

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“…It is known that the iCT-containing C cells of the mammalian thyroid gland originate in the neural crest, migrate to the ultimobranchial body, and finally join with the lateral lobes of the thyroid gland [Kingsbury, 1935;Copp et al, 1967;Le Douarin & Le Lievre, 19701. Both the thyroid gland and the lungs are derivatives of the embryonic pharynx.…”

Section: <002mentioning

confidence: 99%

Pulmonary immunoreactive calcitonin in the African green monkey (Cercopithecus aethiops): Anatomic distribution

Becker

Snider

Moore

et al. 1985

American J Primatol

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The hormone calcitonin, which occurs predominantly within the C cells of the mammalian thyroid gland, is also found within the pulmonary endocrine cells of the epithelium of the tracheobronchial tree. A study was made of the distribution of immunoreactive calcitonin (iCT) in the African green monkey. Using two different region-specific antisera, the total respiratory iCT comprised 2.5% and 5.8% of the total thyroid iCT. The mean concentration of iCT in the right lung exceeded that in the left, and the mean concentration of the right middle or right upper lobe exceeded that of all other lobes. Embryologically, the ultimobranchial bodies contribute their iCT-producing C cell primordia to the thyroid gland near the l e d of the primitive laryngotracheal cleft and shortly after the early arborization of the bronchial tree. In monkeys and most other mammals, the right main stem bronchus is larger and develops earlier than the left. The data suggest an early migration of cells from the ultimobranchial bodies to the bronchi, eventually giving rise to the iCT-containing pulmonary endocrine cells.

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Ultimobranchial Origin of Calcitonin. Hypocalcemic Effect of Extracts From Chicken Glands

Cited by 71 publications

References 0 publications

Evidence for the Presence of Molecules Related to the Neuropeptide CGRP in Two Cephalopods, <i>Sepia officinalis </i>and <i>Nautilus macromphalus</i>: Comparison with Its Target Organ Distribution

Evidence for the Presence of Molecules Related to the Neuropeptide CGRP in Two Cephalopods, <i>Sepia officinalis </i>and <i>Nautilus macromphalus</i>: Comparison with Its Target Organ Distribution

Calcitonin Distribution within Pig, Sheep and Cow Thyroid

Pulmonary immunoreactive calcitonin in the African green monkey (Cercopithecus aethiops): Anatomic distribution

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