Ultra-fast laser microprocessing of medical polymers for cell engineering applications

Ortiz, Rocío; Moreno‐Flores, Susana; Quintana, Iban; Vivanco, María dM; Sarasua, Jose‐Ramon; Toca-Herrera, José L.

doi:10.1016/j.msec.2013.12.039

Cited by 50 publications

(27 citation statements)

References 60 publications

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“…Although the importance of biodegradability, which affects biocompatibility25 and sustainability26, has been discussed in previous studies involving the ultrafast laser processing of biodegradable polymers15161718192021, the effect of ultrashort pulsed laser irradiation on the biodegradability of biodegradable polymers has, to the best of our knowledge, not been reported.…”

Section: Discussionmentioning

confidence: 97%

Biodegradability of poly(lactic-co-glycolic acid) after femtosecond laser irradiation

Shibata

Yada

Terakawa

2016

Sci Rep

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Biodegradation is a key property for biodegradable polymer-based tissue scaffolds because it can provide suitable space for cell growth as well as tailored sustainability depending on their role. Ultrashort pulsed lasers have been widely used for the precise processing of optically transparent materials, including biodegradable polymers. Here, we demonstrated the change in the biodegradation of a poly(lactic-co-glycolic acid) (PLGA) following irradiation with femtosecond laser pulses at different wavelengths. Microscopic observation as well as water absorption and mass change measurement revealed that the biodegradation of the PLGA varied significantly depending on the laser wavelength. There was a significant acceleration of the degradation rate upon 400 nm-laser irradiation, whereas 800 nm-laser irradiation did not induce a comparable degree of change. The X-ray photoelectron spectroscopy analysis indicated that laser pulses at the shorter wavelength dissociated the chemical bonds effectively, resulting in a higher degradation rate at an early stage of degradation.

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Section: Discussionmentioning

confidence: 97%

Biodegradability of poly(lactic-co-glycolic acid) after femtosecond laser irradiation

Shibata

Yada

Terakawa

2016

Sci Rep

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“…In 2014, Ortiz et al reported an investigation on the effect of micropattern on the proliferation and morphology of breast cancer cells. They reported that the pattern direction directly affected cell proliferation, leading to the guided growth of cell clusters along that direction [31]. The structure suitable for controlling cell behavior is not limited to microchannels.…”

Section: Cell Adhesion and Behavior On The Laser-irradiated Surface Omentioning

confidence: 99%

Femtosecond Laser Processing of Biodegradable Polymers

Terakawa

2018

Applied Sciences

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Biodegradable polymers have attracted increasing attention in tissue engineering and drug delivery systems owing to their high biocompatibility and biodegradability. Among the various methods for shape forming and modification of biodegradable polymers, laser processing has advantages in a dry processing approach that can process complex-shaped surfaces without using toxic chemical components. This review provides an overview of femtosecond laser processing of biodegradable polymers, especially in the last decade. The interaction mechanism of femtosecond laser pulse and biodegradable polymers, e.g., bond dissociation after laser irradiation, affects the degradable property of biodegradable polymers, which has the potential to control the degradation and sustainability of a structure. Applied studies on controlling cell behavior, tissue scaffolding, and drug release are also described.

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“…Currently, diode-pumped solid-state lasers (DPSSLs) based on Nd-doped crystals have attracted signicant attention because of their high efficiency, compactness, and high stability and have been widely applied in the elds of medical treatment, industrial processing, military, and optical communication. [2][3][4][5] In this study, considerable efforts have been devoted towards exploring new single crystals with excellent performance and high quality for DPSSLs. For example, Nd-doped vanadate crystals (Nd:LnVO 4 , Ln ¼ Y, Gd, and Lu), represented by Nd:YVO 4 , have been identied to be a series of excellent laser materials with high chemical stability, good laser properties, and high laser damage threshold and commercialized and broadly applied in low-and even moderate-power lasers.…”

Section: Introductionmentioning

confidence: 99%

Crystal growth and characterization of a mixed laser crystal: Nd-doped Gd_0.89La_0.1NbO₄

et al. 2017

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Ultra-fast laser microprocessing of medical polymers for cell engineering applications

Cited by 50 publications

References 60 publications

Biodegradability of poly(lactic-co-glycolic acid) after femtosecond laser irradiation

Biodegradability of poly(lactic-co-glycolic acid) after femtosecond laser irradiation

Femtosecond Laser Processing of Biodegradable Polymers

Crystal growth and characterization of a mixed laser crystal: Nd-doped Gd_0.89La_0.1NbO₄

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Ultra-fast laser microprocessing of medical polymers for cell engineering applications

Cited by 50 publications

References 60 publications

Biodegradability of poly(lactic-co-glycolic acid) after femtosecond laser irradiation

Biodegradability of poly(lactic-co-glycolic acid) after femtosecond laser irradiation

Femtosecond Laser Processing of Biodegradable Polymers

Crystal growth and characterization of a mixed laser crystal: Nd-doped Gd0.89La0.1NbO4

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Product

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Crystal growth and characterization of a mixed laser crystal: Nd-doped Gd_0.89La_0.1NbO₄