Ultrafast cone-beam computed tomography imaging and postprocessing data during image-guided therapeutic practice

Paul, Jijo; Mbalisike, Emmanuel; Vogl, Thomas J.

doi:10.1007/s00330-014-3321-8

Cited by 5 publications

(3 citation statements)

References 24 publications

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“…The partial visualization of hepatic parenchyma on some UCBCT cross-sectional images due to the limited scan coverage (field of view) was compensated using UCBCT-MRI fused image data during tumor diagnosis and TACE Axial section Antero-posterior translation 0.9 ± 0.4 (0-1.8) Right/ left lateral translation 1.1 ± 0.5 (0-1.9) Axial rotation 0.6 ± 0.4 (0-1.7) Coronal section Right/ left lateral translation 0.8 ± 0.4 (0-2.1) Supero-inferior translation 1.8 ± 0.8 (0-2.6) Coronal rotation 0.7 ± 0.6 (0-2.3) Sagittal section Antero-posterior translation 1.2 ± 0.8 (0-2.4) Supero-inferior translation 1.9 ± 0.6 (0-2.5) Sagittal rotation 0.6 ± 0.4 (0-2.2) procedure (figure 4). Fused image data provided many additional advantages such as helping to accurately locate tumor-feeding vessels, properly detect contrast material injection sites, and localize the tip of the catheter using 3D visualization (Paul et al 2014). Furthermore, fusion images enabled the quantitative evaluation of ablation margins during intra-procedural ablation margin assessment (Iwazawa et al 2012).…”

Section: Discussionmentioning

confidence: 99%

“…A patient's 3D anatomical volume can be acquired using UCBCT imaging and the image data utilized to generate multi-planar images to detect target tumors. The acquired 3D patient image data can be post-processed using suitable post-processing software and this in turn generates additional post-processed image datasets (Zellerhoff et al 2009, Struffert et al 2012, van der Bom et al 2012, Royalty et al 2013, Paul et al 2014. Post-processed UCBCT perfusion blood volume (PBV) images and cross-modality UCBCT-MRI (magnetic resonance image) fusion images allow the potential use of multiple image datasets to simultaneously localize the target hepatic tumor.…”

Section: Introductionmentioning

confidence: 99%

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Detectability of hepatic tumors during 3D post-processed ultrafast cone-beam computed tomography

Paul¹,

Vogl²,

Chacko³

2015

Phys. Med. Biol.

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To evaluate hepatic tumor detection using ultrafast cone-beam computed tomography (UCBCT) cross-sectional and 3D post-processed image datasets. 657 patients were examined using UCBCT during hepatic transarterial chemoembolization (TACE), and data were collected retrospectively from January 2012 to September 2014. Tumor detectability, diagnostic ability, detection accuracy and sensitivity were examined for different hepatic tumors using UCBCT cross-sectional, perfusion blood volume (PBV) and UCBCT-MRI (magnetic resonance imaging) fused image datasets. Appropriate statistical tests were used to compare collected sample data. Fused image data showed the significantly higher (all P < 0.05) diagnostic ability for hepatic tumors compared to UCBCT or PBV image data. The detectability of small hepatic tumors (<5 mm) was significantly reduced (all P < 0.05) using UCBCT cross-sectional images compared to MRI or fused image data; however, PBV improved tumor detectability using a color display. Fused image data produced 100% tumor sensitivity due to the simultaneous availability of MRI and UCBCT information during tumor diagnosis. Fused image data produced excellent hepatic tumor sensitivity, detectability and diagnostic ability compared to other datasets assessed. Fused image data is extremely reliable and useful compared to UCBCT cross-sectional or PBV image datasets to depict hepatic tumors during TACE. Partial anatomical visualization on cross-sectional images was compensated by fused image data during tumor diagnosis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Detectability of hepatic tumors during 3D post-processed ultrafast cone-beam computed tomography

Paul¹,

Vogl²,

Chacko³

2015

Phys. Med. Biol.

Self Cite

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“…64,65 Furthermore, the feasibility of ultrafast CBCT, which uses the rotation of a double x-ray tube detector to acquire faster 3D volume data, has been studied with promising results for tumor and feeding vessel detection and catheter localization. 66 …”

Section: Clinical Introduction and Standardization Of Cone-beam Ct Immentioning

confidence: 99%

Interventional Oncology in Hepatocellular Carcinoma

et al. 2016

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The clinical management of hepatocellular carcinoma has evolved greatly in the last decade mostly through recent technical innovations. In particular, the application of cutting edge image guidance has led to minimally invasive solutions for complex clinical problems and rapid advances in the field of interventional oncology. Many image-guided therapies, such as transarterial chemoembolization and radiofrequency ablation have meanwhile been fully integrated into interdisciplinary clinical practice, while others are currently being investigated. This review will summarize and evaluate the most relevant completed and ongoing clinical trials, provide a synopsis of recent innovations in the field of intra-procedural imaging and tumor response assessment, and offer an outlook on new technologies, such as radiopaque embolic materials. In addition, combination therapies consisting of loco-regional therapies and systemic molecular targeted agents (e.g., sorafenib) remains of major interest to the field and will also be discussed. Finally, we will address the many substantial advances in immune response pathways that have been related to the systemic effects of loco-regional therapies. Knowledge of these new developments is crucial as they continue to shape the future of cancer treatment, further establishing interventional oncology along with surgical, medical, and radiation oncology as the 4th pillar of cancer care.

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Cone Beam Computed Tomography (CBCT) in the Field of Interventional Oncology of the Liver

Bapst

Lagadec

Bréguet

et al. 2015

Cardiovasc Intervent Radiol

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Cone beam computed tomography (CBCT) is an imaging modality that provides computed tomographic images using a rotational C-arm equipped with a flat panel detector as part of the Angiography suite. The aim of this technique is to provide additional information to conventional 2D imaging to improve the performance of interventional liver oncology procedures (intraarterial treatments such as chemoembolization or selective internal radiation therapy, and percutaneous tumor ablation). CBCT provides accurate tumor detection and targeting, periprocedural guidance, and post-procedural evaluation of treatment success. This technique can be performed during intraarterial or intravenous contrast agent administration with various acquisition protocols to highlight liver tumors, liver vessels, or the liver parenchyma. The purpose of this review is to present an extensive overview of published data on CBCT in interventional oncology of the liver, for both percutaneous ablation and intraarterial procedures.

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Ultrafast cone-beam computed tomography imaging and postprocessing data during image-guided therapeutic practice

Cited by 5 publications

References 24 publications

Detectability of hepatic tumors during 3D post-processed ultrafast cone-beam computed tomography

Detectability of hepatic tumors during 3D post-processed ultrafast cone-beam computed tomography

Interventional Oncology in Hepatocellular Carcinoma

Cone Beam Computed Tomography (CBCT) in the Field of Interventional Oncology of the Liver

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