Ultrafast photodimerization dynamics in α-cyano-4-hydroxycinnamic and sinapinic acid crystals

Hoyer, Theo; Tuszynski, W.; Lienau, Christoph

doi:10.1016/j.cplett.2007.06.038

Cited by 36 publications

(55 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At least two emitting excited states and photoinduced reaction, possibly dimerization, have been proposed [30]. Even more extensive photoreaction has been proposed for sinapinic acid, with long-lived products [30].…”

Section: Resultsmentioning

confidence: 99%

“…The matrix CHCA is more complicated than DHB [30,34], though it also has been successfully modeled with the CPCD [17]. At least two emitting excited states and photoinduced reaction, possibly dimerization, have been proposed [30].…”

Section: Resultsmentioning

confidence: 99%

“…Singlet exciton pooling in DHB has been repeatedly investigated [29][30][31][32] and is the key process bringing together energy for charge separation in the CPCD. Using the original estimated rate constant for the S n + S 1 pooling step, 10 9 s…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Ion Yields in the Coupled Chemical and Physical Dynamics Model of Matrix-Assisted Laser Desorption/Ionization

Knochenmuss¹

2015

J. Am. Soc. Mass Spectrom.

View full text Add to dashboard Cite

Abstract. The Coupled Chemical and Physical Dynamics (CPCD) model of matrix assisted laser desorption ionization has been restricted to relative rather than absolute yield comparisons because the rate constant for one step in the model was not accurately known. Recent measurements are used to constrain this constant, leading to good agreement with experimental yield versus fluence data for 2,5-dihydroxybenzoic acid. Parameters for alpha-cyano-4-hydroxycinnamic acid are also estimated, including contributions from a possible triplet state. The results are compared with the polar fluid model, the CPCD is found to give better agreement with the data.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Ion Yields in the Coupled Chemical and Physical Dynamics Model of Matrix-Assisted Laser Desorption/Ionization

Knochenmuss¹

2015

J. Am. Soc. Mass Spectrom.

View full text Add to dashboard Cite

show abstract

“…A very minor decline of both signals (within a factor of 2-3) with increasing sputter time is probably caused by the changes in the matrix diameter, or possibly some spatial segregation effect, rather than by an Ar beam-induced degradation of matrix or analytes. This differentiates the method from the MALDI analysis of cinnamic acid derivatives, where laser-induced thermal-/photochemical modifications degrade the matrix performance [15][16][17][18][19]. Figure 2 shows the 2D distribution of bradykinin across the initial top crystal surface and at approximately 1/3 depth.…”

Section: Integral Depth Profilesmentioning

confidence: 99%

“…In particular for cinnamic acid-derived matrices, a strong deterioration of the ion signals is typically observed with an accumulating number of laser pulses applied to one position [16,17]. This has been attributed to laser-induced thermal and photochemical modifications of the matrix compounds [18,19]. Despite these limitations, the above MALDI-MS imaging studies clearly indicated the occurrence of analyte segregation within the analytematrix crystals; in particular the hydrophobicity of a compound seems to affect the overall co-crystallization process [14,15].…”

Section: Introductionmentioning

confidence: 99%

3D ToF-SIMS Analysis of Peptide Incorporation into MALDI Matrix Crystals with Sub-micrometer Resolution

Körsgen

Pelster

Dreisewerd

et al. 2015

J. Am. Soc. Mass Spectrom.

View full text Add to dashboard Cite

Abstract. The analytical sensitivity in matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) is largely affected by the specific analyte-matrix interaction, in particular by the possible incorporation of the analytes into crystalline MALDI matrices. Here we used time-of-flight secondary ion mass spectrometry (ToF-SIMS) to visualize the incorporation of three peptides with different hydrophobicities, bradykinin, Substance P, and vasopressin, into two classic MALDI matrices, 2,5-dihydroxybenzoic acid (DHB) and α-cyano-4-hydroxycinnamic acid (HCCA). For depth profiling, an Ar cluster ion beam was used to gradually sputter through the matrix crystals without causing significant degradation of matrix or biomolecules. A pulsed Bi 3 ion cluster beam was used to image the lateral analyte distribution in the center of the sputter crater. Using this dual beam technique, the 3D distribution of the analytes and spatial segregation effects within the matrix crystals were imaged with sub-μm resolution. The technique could in the future enable matrix-enhanced (ME)-ToF-SIMS imaging of peptides in tissue slices at ultra-high resolution.

show abstract

The MALDI Process and Method

2013

View full text Add to dashboard Cite

Ultrafast photodimerization dynamics in α-cyano-4-hydroxycinnamic and sinapinic acid crystals

Cited by 36 publications

References 23 publications

Ion Yields in the Coupled Chemical and Physical Dynamics Model of Matrix-Assisted Laser Desorption/Ionization

Ion Yields in the Coupled Chemical and Physical Dynamics Model of Matrix-Assisted Laser Desorption/Ionization

3D ToF-SIMS Analysis of Peptide Incorporation into MALDI Matrix Crystals with Sub-micrometer Resolution

The MALDI Process and Method

Contact Info

Product

Resources

About