Ultrafine calcium–titania–polyester dry powder coatings promote human mesenchymal cell attachment and biomineralization

Hou, Nicholas; Zhu, Jesse; Zhou, Hui; Perinpanayagam, Hiran

doi:10.1016/j.surfcoat.2014.04.022

Cited by 11 publications

(17 citation statements)

References 26 publications

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“…This cell line has provided us with a clinically-relevant model to study the cellular response to implant surfaces [29][30][31]. Our cellular studies demonstrated that the human mesenchymal cells attached, extended, proliferated, differentiated, and initiated biomineralization on the surfaces of modified biomaterials [2,3,24,25]. Through these studies, our research group hopes to use ultra-fine particle technology to develop more biocompatible and osteo-inductive biomaterial surfaces to improve the efficacy of orthopedic and bone implants.…”

Section: Introductionmentioning

confidence: 83%

“…Only with sufficient levels of osteo-integration, the host can then provide proper anchorage to retain the implant, decreasing the chances for loosening of the implant and increasing its post-surgical success. Thus, much of the current research interest has been invested to improve the biocompability and the osteo-integration of orthopedic implants [2,3].…”

Section: Introductionmentioning

confidence: 99%

“…Similarly, based on this idea, our research team demonstrated that not only was our technology able to develop coat surfaces using ultrafine powder coating, but the utilization of functional additives also opened a realm which allows research to enrich surfaces with specific properties. During this study, we will discuss a collection of the uses of this technology along with functional additives for improving the biocompability and the osteo-inductivity of orthopedic implants [2,3,[24][25][26].…”

Section: Introductionmentioning

confidence: 99%

“…Various calcium-containing functional additive mixtures were then incorporated to the coating, forming a surface that promoted bone formation [27,28]. The functional additives consisted of only a small fraction of the surface coating particles to ensure the composition and integrity of the polyester [2,3]. Nevertheless, significant physical and biological differences were observed in cell cultures [2,3].…”

Section: Introductionmentioning

confidence: 99%

“…The functional additives consisted of only a small fraction of the surface coating particles to ensure the composition and integrity of the polyester [2,3]. Nevertheless, significant physical and biological differences were observed in cell cultures [2,3]. Over the last few years, we demonstrated that through this technique, we were able to construct uniform, continuous, homogenous, and highly adherent, as well as biocompatible, polymer coatings.…”

Section: Introductionmentioning

confidence: 99%

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Novel Development of Biocompatible Coatings for Bone Implants

et al. 2015

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Prolonged life expectancy also results in an increased need for high-performance orthopedic implants. It has been shown that a compromised tissue-implant interface could lead to adverse immune-responses and even the dislodging of the implant. To overcome these obstacles, our research team has been seeking ways to decrease the risk of faulty tissue-implant interfaces by improving the biocompatibility and the osteo-inductivity of conventional orthopedic implants using ultrafine particle coatings. These particles were enriched with various bioactive additives prior to coating, and the coated biomaterial surfaces exhibited significantly increased biocompatibility and osteoinductivity. Physical assessments firstly confirmed the proper incorporation of the bioactive additives after examining their surface chemical composition. Then, in vitro assays demonstrated the biocompatibility and osteo-inductivity of the coated surfaces by studying the morphology of attached cells and their mineralization abilities. In addition, by quantifying the responses, activities and gene expressions, cellular evaluations confirmed the positive effects of these polymer based bioactive coatings. Consequently, the bioactive ultrafine polymer particles demonstrated their ability in improving the biocompatibility and osteo-inductivity of conventional orthopedic implants. As a result, our research team hope to apply this technology to the field of orthopedic implants by making them more effective medical devices through decreasing the risk of implant-induced immune responses and the loosening of the implant. OPEN ACCESSCoatings 2015, 5 738

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Section: Introductionmentioning

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Novel Development of Biocompatible Coatings for Bone Implants

et al. 2015

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Preparation and characteristics of polyacrylic ester‐based water‐free powder coatings in supercritical carbon dioxide

Yang

Cheng

Chen

et al. 2015

J of Applied Polymer Sci

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Powder coating for dry coating technique of paper as the promising method has attracted more and more attentions in recent years due to its advantages in reducing the dosage of water and saving energy compared with conventional coating. This study focused on the in situ polymerization of methyl methacrylate (PMMA) under a water-free condition in supercritical carbon dioxide in the presence of inorganic kaolin. The effects of varying the concentrations of the monomer, initiator, and stabilizer on the molecular weight and morphology of the resultant PMMA were investigated and discussed. Then the powder coating was systematically evaluated and characterized by gel permeation chromatography, scanning electron microscopy, Fourier transform infrared spectroscopy, and thermogravimetric analysis. Meanwhile, the feasibility of manufacturing PMMA/kaolin powder coatings was explored, and the mechanism of polymerization and the thermal degradation kinetics of powder coating were studied. The experimental results showed that the properties of PMMA as a film former were suitable with the molecular weight and narrow molecular weight distribution close to that in conventional coating when the concentration of monomer was about 10 wt %, concentration of initiator 1-1.5 wt % and stabilizer about 10 wt % with respect to monomer. Moreover, the interfacial bonds and dispersion situation of polyacrylic ester-based water-free powder coating particles were fairly well, the powder coating possesses good film-forming property combined with outstanding thermal-stability performance. The combination of these characteristics makes PMMA/kaolin powder coating an excellent candidate for dry coating technique of paper applications.

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Epoxy resin‐based ultrafine dry powder coatings for implants

Hou

Zhu

Zhang

et al. 2016

J of Applied Polymer Sci

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Ultrafine dry powder coating technology creates biocompatible polymeric coatings for implants. Nanoparticles (nTiO 2 ) modify flow to prevent agglomeration and create homogenous coatings. Since polyester-based coatings require the potentially harmful 1,3,5-triglycidyl isocyanurate (TGIC) curing agent, this study's objective was to develop alternative TGIC-free formulations. Epoxy and epoxy/polyester (1:1) hybrid mixtures were enriched with CaO (5% w/w) and nTiO 2 (0.5% w/w), as functional additives and flow modifiers, respectively. Epoxy-TiO 2 and Hybrid-TiO 2 mixtures were prepared with micron-sized TiO 2 (25% w/w) to enhance biocompatibility. Polymer chips and additives were combined in a high-shear mixer and passed through a sieve (35 mm) to yield ultrafine particles that were sprayed (20 kV) onto metal sheets and cured (200 8C). Particle size analyses showed that all formulations were ultrafine (D 0.5 < 35 mm), and epoxy/polyester/TiO 2 mixtures were the smallest (D 0.5 5 16.34 mm). Angles of repose, avalanche and resting indicated reduced flowability when epoxy was enriched with TiO 2 and/or polyester, although all formulae were highly flowable. Elemental mapping of coatings showed a predominance of carbon (C) and oxygen (O) from resin polymer, and elevated titanium (Ti) in the TiO 2 enriched surfaces. However, calcium (Ca) clusters were higher on the epoxy/polyester Hybrid coatings. Optical microscopy showed human mesenchymal cells (ATCC CRL-1486) attached and spread out, and Alizarin Red staining showed mineral deposits in 2-4 week cultures, particularly on epoxy/polyester/TiO 2 Hybrid surfaces. These epoxy resin-based formulations were effective TGIC-free substitutes for ultrafine dry powder coatings on implants. V C 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43960.

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Ultrafine calcium–titania–polyester dry powder coatings promote human mesenchymal cell attachment and biomineralization

Cited by 11 publications

References 26 publications

Novel Development of Biocompatible Coatings for Bone Implants

Novel Development of Biocompatible Coatings for Bone Implants

Preparation and characteristics of polyacrylic ester‐based water‐free powder coatings in supercritical carbon dioxide

Epoxy resin‐based ultrafine dry powder coatings for implants

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