Ultralow‐field and spin‐locking relaxation dispersion in postmortem pig brain

Dong, Huafeng; Hwang, Sung Ho; Wendland, Michael F.; You, Lixing; Clarke, John; Inglis, Ben

doi:10.1002/mrm.26621

Cited by 5 publications

(4 citation statements)

References 70 publications

(122 reference statements)

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“…These include the relatively high similarity between the pigs and human organs, the physiology and disease development, as well as the shareability of porcine and human genome, transcriptome, proteome, and other database tools. With the rapid development of genetic research and biotechnology in recent years, it has become feasible to construct transgenic pigs with specific genes that can be used in human models of infectious diseases, such as viruses, bacteria, parasitic transmission, and various tumor models 21,22 . Besides, there has been a gradual increase in studies related to brain lesions in experimental miniature pigs.…”

Section: Discussionmentioning

confidence: 99%

“…With the rapid development of genetic research and biotechnology in recent years, it has become feasible to construct transgenic pigs with specific genes that can be used in human models of infectious diseases, such as viruses, bacteria, parasitic transmission, and various tumor models. 21 , 22 Besides, there has been a gradual increase in studies related to brain lesions in experimental miniature pigs. In 2014, Matthew proposed that the major brain growth bursts in minipigs extend from prenatal to postnatal, similar to humans, and that their brain convolution patterns, gray and white matter distrivution are so similar to human infants.…”

Section: Discussionmentioning

confidence: 99%

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Brain structure analysis of different age groups of Diannan small‐ear pigs

Liu

Fang

et al. 2022

Ibrain

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The objective of the study is to investigate the brain development and atrophy of Diannan small-ear pigs in different ages using magnetic resonance imaging (MRI). A total of 12 Diannan small-ear pigs were included and divided into the young group, adult group, and middle-and-old age (M&O) group according to their age. The brain structure of pigs was scanned using MRI, and the brain data obtained were statistically analyzed by signal conversion and image reconstruction. Compared with the young group, the signals of most brain structures in the adult group and M&O group were significantly decreased (p < 0.05). Compared with the adult group, the signal intensity of the right caudate nucleus and the right lateral ventricle in the M&O group was significantly increased, while the signal intensity of other regions was almost significantly decreased (p < 0.05). Compared with the young group, both adult and M&O groups had some degree of brain atrophy. Brain atrophy in the precuneus and the inferior temporal gyrus was more predominant in the M&O group in comparison with the adult group. The present study demonstrated that the brain signal of Diannan small-ear pigs gradually diminished with age, while the degree of brain atrophy was the opposite, providing the basic data on the brain of Diannan small-ear pigs.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Brain structure analysis of different age groups of Diannan small‐ear pigs

Liu

Fang

et al. 2022

Ibrain

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“…Compared to high magnetic field MRI, ULF NMR/MRI has the advantage of improved portability, lower cost, enhanced contrast between benign and cancerous tissues, and the possibility of simultaneous acquisition with MEG. Pioneering applications of ULF NMR/MRI have been successfully developed by a number of women, such as a liquid explosive detection technique, a combined MEG and ULF MRI system, by Espy (Los Alamos National Laboratory (LANL)) [88], a dispersion contrast study [89] and magnetic resonance switches for biosensing by Dong (SIMIT) [90], and tumour discrimination by Horng (National Taiwan Normal University) [91]. Figure 12 shows a ULF NMR/MRI system, developed by Dong with her team at SIMIT.…”

Section: Squid Technologymentioning

confidence: 99%

The 2022 applied physics by pioneering women: a roadmap

Mayor

Alberi

Ayers³

et al. 2023

J. Phys. D: Appl. Phys.

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Women have made significant contributions to applied physics research and development, and their participation is vital to continued progress. Recognizing these contributions is important for encouraging increased involvement and creating an equitable environment in which women can thrive. This Roadmap on Women in Applied Physics, written by women scientists and engineers, is intended to celebrate women’s accomplishments, highlight established and early career researchers enlarging the boundaries in their respective fields, and promote increased visibility for the impact women have on applied physics research. Perspectives cover the topics of plasma materials processing and propulsion, super-resolution microscopy, bioelectronics, spintronics, superconducting quantum interference device technology, quantum materials, 2D materials, catalysis and surface science, fuel cells, batteries, photovoltaics, neuromorphic computing and devices, nanophotonics and nanophononics, and nanomagnetism. Our intent is to inspire more women to enter these fields and encourage an atmosphere of inclusion within the scientific community.

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“…导SQUID的极低场磁共振研究, 第二年即在国际上首次在恶劣城市电磁环境中观测到无屏蔽核磁信号 [82] . 上海微系统所针对环境电磁干扰问题研发了一系列噪声抑制和屏蔽技术, 目前信号频段的磁场噪声在0.8 fT/Hz 1/2 左右 [83−86] , 并已获得多通道三维MRI图像 [87] . 已开展的应用研究包括:…”

Section: 上海微系统所与吉林大学联合开展的超导Tem 仪器与传统仪器相比低温超导Tem在浅层分辨unclassified

Recent progress of superconducting electronics in China

Li¹,

Wang²,

Wu³

et al. 2021

Acta Phys. Sin.

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It has been nearly 110 years since the discovery of superconductors, and more than 30 years since the discovery of high temperature superconductors (HTS). Great progress has been made in the application of superconducting electronics in the last two decades. HTS microwave devices have shown much higher perfomance than the traditional ones and have found their ways to the industry applications in mobile communication, radar, and special communication applications. Owing to the ultrahigh sensitivity to magnetic fields and currents, superconducting quantum interference devices (SQUIDs) have been used as the irresplacible sensors in geological surveying, magnetic resonanc imaging, biomagnetic imaging, and other areas. The sensitivity of superconducting radiation detectors such as superconducting SIS mixer, superconducting hot electron bolometer, superconducting transition edge sensor, superconducting nanowire single photon detector, and superconducting microwave kinetic inductance detector are near the quantum limitation. They are now key technology in geophysics, astrophysics, quantum information science, biomedicine, and so on. Superconducting Josephson parametric amplifier has become a key element for superconducting quantum computing. Superconducting integrated circuit has been included in the international roadmap for devices and systems, and shows that having the potential to become one of the mainstreams for post-Moore information processing technology. In metrology, superconducting Josephson effect and Josephson junction array devices have been widely used in the redefinition of quantum voltage reference and basic units of the International system of Units. Superconducting electronics plays an important role in the current quantum information technology boom, which in turn promotes the development of superconducting electronics. This review will brief introduce the research and application of superconducting electronics in China in recent years.

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Ultralow‐field and spin‐locking relaxation dispersion in postmortem pig brain

Abstract: Ultralow-field MRI may offer distinct, quantitative advantages for human brain imaging, while simultaneously avoiding the severe heating limitation imposed on high-field spin locking. Magn Reson Med 78:2342-2351, 2017. © 2016 International Society for Magnetic Resonance in Medicine.

Cited by 5 publications

References 70 publications

Brain structure analysis of different age groups of Diannan small‐ear pigs

Brain structure analysis of different age groups of Diannan small‐ear pigs

The 2022 applied physics by pioneering women: a roadmap

Recent progress of superconducting electronics in China

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