2022
DOI: 10.1021/acsami.1c17349
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Ultrasensitive Bioelectronic Tongue Based on the Venus Flytrap Domain of a Human Sweet Taste Receptor

Abstract: Sweet taste is an important factor that regulates calorie intake and contributes to food preferences in humans and animals. Therefore, the evaluation of sweet substances is essential for various fields such as healthcare, food, and pharmaceutical industries. Sweet tastants are detected by sweet taste receptors which are class C G-protein-coupled receptors (GPCRs). T1R2 venus flytrap (VFT) of sweet taste receptor is known as a primary ligand-binding domain for sweet tastants. In this study, we developed an ultr… Show more

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Cited by 21 publications
(19 citation statements)
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“…A CNT-FET was fabricated following the previously reported method . Here, source and drain electrodes (Au (30 nm) on Ti (10 nm)) were first patterned on a Si/SiO 2 substrate via photolithography.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…A CNT-FET was fabricated following the previously reported method . Here, source and drain electrodes (Au (30 nm) on Ti (10 nm)) were first patterned on a Si/SiO 2 substrate via photolithography.…”
Section: Methodsmentioning
confidence: 99%
“…A CNT-FET was fabricated following the previously reported method. 32 Here, source and drain electrodes (Au (30 nm) on Ti (10 nm)) were first patterned on a Si/SiO 2 substrate via photolithography. Single-walled CNTs were dissolved in dichlorobenzene (DCB) at 0.05 mg/mL and sonicated for 3 h to prepare CNT suspensions.…”
Section: ■ Experimental Sectionmentioning
confidence: 99%
“…(f) Sensing mechanism of the device. Reproduced with permission [ 76 ]. Copyright 2022, American chemical society.…”
Section: Artificial Perception System Based On Neuromorphic Transistorsmentioning
confidence: 99%
“…The responses at high concentrations, including 500 pM and 1 nM, exhibited less than 5% differences, while the lower concentrations displayed more deviations (Figure S7C). From these observations, it is likely that other components in citrus interacted with the sensor and promoted the signal . Hence, additional analyses with fruit sample preparations are needed to reduce interference, and the development of a bioelectronic nose utilizing peptide probes derived from our screening would greatly improve our discrimination system for fruit detection. , Finally, the stability and reproducibility of the LBP3-gFET sensor were demonstrated by utilizing the internal and external coefficients of variation (CV) from limonene detections with multiple sensor devices as shown in Figure S8. , The internal CVs among sensing channels in one sensor device exhibited high consistency at concentrations greater than 10 pM (higher than interval of confidence) with CVs of 6% to 10%.…”
Section: Resultsmentioning
confidence: 98%