Ultrasensitive graphene coated SPR sensor for biosensing applications

Bhavsar, Kaushalkumar; Prabhu, Radhakrishna; Pollard, Pat

doi:10.1117/12.2179051

Cited by 3 publications

(2 citation statements)

References 25 publications

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“…When the introduction of DENV-2 E-proteins was higher than 0.001 nM, the reflectance curves remain unchanged at 54.408° due to the maximum binding of DENV-2 E-proteins. The observion of this phenomenon is mainly due to the difficulty of SPR evanescent wave in penetrating the thick dielectric layer, which then reduces the sensitivity of the SPR sensor [ 76 , 77 ].…”

Section: Resultsmentioning

confidence: 99%

“…When the introduction of DENV-2 E-proteins was higher than 0.001 nM, the reflectance curves remain unchanged at 54.408 • due to the maximum binding of DENV-2 E-proteins. The observion of this phenomenon is mainly due to the difficulty of SPR evanescent wave in penetrating the thick dielectric layer, which then reduces the sensitivity of the SPR sensor [76,77]. Next, the Au/DSU/NH2rGO-PAMAM/IgM-based SPR sensor response towards a lower range of DENV-2 E-protein concentration (0.000008 nM to 0.0001 nM) was conducted to determine the lowest detectable concentration for DENV-2 E-proteins, or on the other hand, to determine the detection limit obtained by this sensor.…”

Section: Incorporation Of Au/dsu/nh2rgo-pamam/igm Sensor Film Into Spr Systemmentioning

confidence: 99%

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An Optical Sensor for Dengue Envelope Proteins Using Polyamidoamine Dendrimer Biopolymer-Based Nanocomposite Thin Film: Enhanced Sensitivity, Selectivity, and Recovery Studies

et al. 2021

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This paper proposes a novel idea to enhance the sensitivity and selectivity of surface plasmon resonance (SPR) optical sensor for detection of dengue virus type-2 envelope proteins (DENV-2 E-proteins) using polyamidoamine (PAMAM) dendrimer biopolymer-based nanocomposite thin film. For this purpose, two ranges of DENV-2 E-protein concentrations, i.e., 0.000008–0.0001 nM and 0.00008–0.005 nM were evaluated, and the lowest detectable concentration was achieved at 0.00008 nM. The incorporation of PAMAM dendrimer-based nanocomposite thin film with an SPR sensor exhibited a significant increase in sensitivity and binding affinity to a lower range DENV-2 E-protein concentrations. Moreover, the proposed sensor displayed good selectivity towards DENV-2 E-proteins and have an average recovery of 80–120%. The findings of this study demonstrated that PAMAM dendrimer-based nanocomposite thin film combined with SPR sensor is a promising diagnostic tool for sensitive and selective detection of DENV-2 E-proteins.

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Section: Resultsmentioning

confidence: 99%

Section: Incorporation Of Au/dsu/nh2rgo-pamam/igm Sensor Film Into Spr Systemmentioning

confidence: 99%