Ultrasensitive label-free detection of DNA hybridization by sapphire-based graphene field-effect transistor biosensor

Xu, Shicai; Jiang, Shouzhen; Zhang, Chao; Yue, Weiwei; Zou, Yan; Wang, Guiying; Liu, Huilan; Zhang, Xiumei; Li, Mingzhen; Zhu, Zi‐Zhong; Wang, Jihua

doi:10.1016/j.apsusc.2017.09.113

Cited by 86 publications

(57 citation statements)

References 33 publications

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“…nucleotide variation [15]. Figure 1 schematically illustrates a method of synthesizing the D-type fiber optic sensor.…”

Section: Production Of D-type Fibermentioning

confidence: 99%

“…The following is the specificity detection of the D-type fiber biosensor for DNA hybridization. We used PBASE as an adhesive to attach the probe DNA to the surface of graphene so that we could fix the probe DNA without creating defects [15]. First, we dissolved the PBASE powder in DMSO to make the binder we need.…”

Section: The Specific Detection Of Biosensormentioning

confidence: 99%

“…However, because of the poor chemical stability of some metals, their adsorption capacity is weak. The weak chemical modification ability of these sensitive layers often limits their practical application [15].…”

Section: Introductionmentioning

confidence: 99%

“…In optical methods, label-free SPR is a convenient tool for DNA binding detection [19,30]. DNA hybridization refers to a biomolecular method for obtaining genetic differences between organisms by evaluating the genetic relationships between DNA sequence libraries [15]. DNA hybridization has important theoretical value and practical significance in gene screening and detection, disease biomarkers, transcriptional profiling and discovery of single nucleotide variation [15].…”

Section: Introductionmentioning

confidence: 99%

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An Au Nanofilm-Graphene/D-Type Fiber Surface Plasmon Resonance Sensor for Highly Sensitive Specificity Bioanalysis

et al. 2020

Sensors

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A highly sensitive Au-graphene structure D-type fiber surface plasmon resonance biosensor is presented in this study to specifically detect biomolecules. The method of growing graphene is employed directly on the copper, and then a gold film of optimum thickness is sputtered, and the copper foil is etched to obtain the structure. This method makes the contact closer between the gold layer and the graphene layer to improve surface plasmon resonance performance. The performance of this type of surface plasmon resonance (SPR) sensor has been previously verified both theoretically and experimentally. With the proposed Au-graphene structure D-type fiber biosensor, the SPR behaviors are obtained and discussed. In the detection of ethanol solution, a red shift of 40 nm is found between the refractive index of 1.3330 and 1.3657. By calculation, the sensitivity of the sensor we designed is 1223 nm/RIU. Besides, the proposed sensor can detect the nucleotide bonding between the double-stranded DNA helix structures. Thus, our sensors can distinguish between mismatched DNA sequences.

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“…nucleotide variation [15]. Figure 1 schematically illustrates a method of synthesizing the D-type fiber optic sensor.…”

Section: Production Of D-type Fibermentioning

confidence: 99%

Section: The Specific Detection Of Biosensormentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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An Au Nanofilm-Graphene/D-Type Fiber Surface Plasmon Resonance Sensor for Highly Sensitive Specificity Bioanalysis

et al. 2020

Sensors

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“…Besides, many other FET based DNA sensors could also achieve efficient DNA sensing and detection. [28][29][30][31][32][33] The carbon nanotube thin lm transistor (CNT-TFT) is another well-developed biosensing platform and can capture tiny signals for bio-analysis. 34,35 The target molecules are recognized and captured on the active CNT channel, resulting in the amplication of a tiny response for further detection.…”

Section: Introductionmentioning

confidence: 99%