Ultrasensitive NO Sensor Based on a Nickel Single-Atom Electrocatalyst for Preliminary Screening of COVID-19

Abstract

A new coronavirus, SARS-CoV-2, has caused the coronavirus disease-2019 (COVID-19) epidemic. A rapid and economical method for preliminary screening of COVID-19 may help to control the COVID-19 pandemic. Here, we report a nickel single-atom electrocatalyst that can be printed on a paper-printing sensor for preliminary screening of COVID-19 suspects by efficient detection of fractional exhaled nitric oxide (FeNO). The FeNO value is confirmed to be related to COVID-19 in our exploratory clinical study, and a machine learning model that can accurately classify healthy subjects and COVID-19 patients is established based on FeNO and other features. The nickel single-atom electrocatalyst consists of a single nickel atom with N2O2 coordination embedded in porous acetylene black (named Ni-N2O2/AB). A paper-printed sensor was fabricated with the material and showed ultrasensitive response to NO in the range of 0.3–180 ppb. This ultrasensitive sensor could be applied to preliminary screening of COVID-19 in everyday life.

Building porphyrin-based MOFs on MXenes for ppb-level NO sensing

“…[3][4][5] Moreover, some studies have shown that FeNO level is a predictor of COVID-19 disease severity. [6][7][8][9] Obviously, the detection of ppb-level nitric oxide (NO) has its unique credit in the clinical diagnosis of respiratory diseases.…”

Rh single-atom nanozymes for efficient ascorbic acid oxidation and detection

“…16,17,31 However, few studies have been reported on the design of SACbased electrochemical sensors. [32][33][34] Furthermore, the active site of natural ascorbate peroxidase has been characterized as a central iron ion coordinated by the four pyrrole nitrogen atoms, 35,36 yet the design of SACs to mimic such structures with desirable activity remains a significant challenge.…”

Noninvasive Electrochemical Nitric Oxide Detection in Human Saliva Using Pt and TiO2 Nanoparticle Composite Electrodes

“…A recent study showed that human saliva also contains NO in nano-micromolar levels. , Oral bacteria and salivary glands play a major role in the conversion process of NO from nitrate (NO 3 ) or nitrite (NO 2 ) in the salivary fluid. − Any increase and decrease in the NO level in saliva can cause several deadly diseases including ischemia, hypertension, Parkinson, myocardial infarction, and cancer. − Oral diseases like periodontitis are also linked to higher NO concentrations in saliva …”