Ultrasensitive spectrofluorimetric method for rapid determination of daclatasvir and ledipasvir in human plasma and pharmaceutical formulations

Highly sensitive spectrofluorimetric method for rapid determination of orciprenaline in biological fluids and pharmaceuticals

“…Therefore there was no need for sample enrichment procedures and this led to shorter analysis times. This approach has been reported in several previous papers and resulted in complete protein precipitation. Table shows the results of the ORP assay in spiked human plasma and urine.…”

Novel spectrofluorimetric approach for determination of ledipasvir through UV-irradiation: application to biological fluids, pharmacokinetic study and content uniformity test

“…5 Due to its recent introduction in the market, few techniques were reported for LDS estimation including chromatographic, 6-9 spectrophotometric 10,11 and spectrouorimetric methods. [12][13][14] Although the reported chromatographic techniques are sensitive enough, [6][7][8] they are subject to extraction procedures as the plasma samples contain a high content of phospholipids as well as it requires expensive organic solvents and long operating time. 15 In addition, all the reported UV methods were restricted to the estimation of LDS in the tablets dosage only without extension to biological uids analysis due to their limited selectivity and sensitivity.…”

“…10,11 The spectrouorometric technique is one of the well-known analytical tools that provide the goal of increasing the method simplicity, selectivity and sensitivity without loss of precision. 16 In spite of the reported spectrouorimetric methods [12][13][14] were applied for the determination of LDS in the plasma and tablets but they not extended to pharmacokinetic study and content uniformity test of LDS by this technique. Moreover, up till now the determination of LDS in the faecal samples (the major excretion route for LDS 5 ) was not reported by any technique.…”

Pencil Graphite Electrode Decorated with Xylenol Orange Flakes for Studying Possible Pharmacokinetic Interaction Between Vardenafil and Daclatasvir

“…The reported analytical methods for determination of VAR include liquid chromatography [6][7][8][9][10][11], gas chromatography [12], atomic emission spectrometry [13], capillary electrophoresis [14], voltammetric methods [15][16][17] and different spectroscopic methods [18][19][20][21][22][23][24][25]. In addition, several methods were reported for quantitative determination of DAC either alone or simultaneously with the other newly approved drugs including different chromatographic methods [26][27][28][29], stability indicating HPLC studies in bulk and formulations [30][31][32][33], electrochemical methods [34][35][36], spectrofluorimetric methods [37][38][39] and thin layer chromatographic method [40].…”