Ultrashort Bowel Syndrome in Children

Sanchez, Sabrina E.; Javid, Patrick J.; Healey, Patrick J.; Reyes, Jorgé; Horslen, Simon

doi:10.1097/mpg.0b013e318266245f

Cited by 27 publications

(19 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present cohort, >90% of the patients underwent procedures to reestablish continuity over a period ranging from 0 to 150 days. Bowel-lengthening procedures are a part of our intestinal rehabilitation program; however, in this particular subgroup of patients, as similarly reported by other teams (11), we agree that, given the shortness of the residual small bowel, the gain of length after any procedure will not significantly improve absorption. As other teams have done with similar patients (11), no child was proposed to undergo a bowel-lengthening procedure in this series.…”

Section: Discussionsupporting

confidence: 79%

Long‐Term Outcome of Home Parenteral Nutrition in Patients With Ultra‐Short Bowel Syndrome

Diamanti

Conforti²,

Panetta

et al. 2014

J. pediatr. gastroenterol. nutr.

View full text Add to dashboard Cite

The survival of patients with U-SBS receiving HPN was good. Although IFALD was frequent, it had been manageable in most of the patients, but in a single complex case, it led to death. The multidisciplinary management warranted to these patients to approach the school age, to grow, and to maintain the oral intake. Patients with U-SBS are rare, and to better understand their long-term survival, further studies, including more large patient populations, are required.

show abstract

Section: Discussionsupporting

confidence: 79%

Long‐Term Outcome of Home Parenteral Nutrition in Patients With Ultra‐Short Bowel Syndrome

Diamanti

Conforti²,

Panetta

et al. 2014

J. pediatr. gastroenterol. nutr.

View full text Add to dashboard Cite

show abstract

“…The inclusion criteria were having a small intestine of up to 10 cm at the time of resection, according to the current definition of USBS , undergoing an intestine resection in the first two months of life and receiving PN for at least six months after their resection. The exclusion criteria were abnormal renal function, symptoms of sepsis at the time of study entry and urea cycle disorders.…”

Section: Methodsmentioning

confidence: 99%

Nutritional therapy complications in children with ultra‐short bowel syndrome include growth deficiency but not cholestasis

et al. 2018

View full text Add to dashboard Cite

AimChildren with ultra‐short bowel syndrome (USBS) have not been extensively studied to date because the condition is rare. The aim of the study was to assess the nutritional status of children with USBS receiving home parenteral nutrition, using citrulline serum concentration and cholestasis.MethodsWe studied 17 patients with USBS, with a median age of 6.6 years and median duration of parenteral nutrition of 6.6 years. The study was carried out at The Children's Memorial Health Institute, Warsaw, from January 2014 to January 2015.ResultsThe median standard deviation score (SDS) was −1.2 for body mass according to chronological age, −1.72 according to height and −0.59 according to height for age. Patients requiring seven days per week parenteral nutrition had a citrulline concentration below 10 μmol/L. Decreased bone‐mineral density was observed in 87% of the patients. Low values of 25‐hydroxyvitamin D were found in 53% of the children. None of the patients had elevated conjugated bilirubin levels above 34.2 μmol/L.ConclusionChildren with USBS were growth deficient according to their chronological age, with frequent abnormal bone mineralisation and vitamin D deficiency. Children requiring parenteral nutrition seven days a week had citrulline concentrations below 10 μmol/L. Cholestasis was not seen.

show abstract

“…Our findings are consistent with other reports. A small recent case series of a prospective database (2005-2011) reported 100% survival of patients with <10 cm of bowel (n ¼ 5) after a median follow-up of 54 months (43-61 months), and notably none of whom developed IFALD (19). A second case series of patients (2001-2011) with < 20 cm small bowel reported that nearly 50% of these patients achieved PN independence within 24 months and significant improvements in total bilirubin when treated at an intestinal rehabilitation program (5).…”

mentioning

confidence: 99%

Pediatric Intestinal Transplant Listing Criteria – A Call for a Change in the New Era of Intestinal Failure Outcomes

Burghardt

Wales

Silva³

et al. 2015

American Journal of Transplantation

View full text Add to dashboard Cite

Current listing indications used for intestinal transplantation (IT) were proposed in 2001. We undertook the present single center study to see if these criteria are still valid. The 2001 criteria (advanced cholestasis, loss of >50% central venous catheter (CVC) sites, !2 sepsis/year, ultrashort bowel) were compared in children with intestinal failure in old era-1998-2005 (N ¼ 99) to current era-2006-2012 (N ¼ 91) to predict the need for IT using sensitivity, specificity, NPV and PPV. Two 2001 criteria had poorer predictive value in the current era: Advanced cholestasis (PPV 64% old vs. 40% current era; sensitivity 84% vs. 65%, respectively) and ultrashort bowel (PPV 100% old vs. 9% current era; sensitivity 10% vs. 4%, respectively). Three newly proposed criteria had high predictive value: !2 ICU admissions (p ¼ 0.0001, OR 23.6, 95% CI 2.7-209.8), persistent bilirubin >75 mmol/L despite lipid strategies (p ¼ 0.0005, OR 24.0, 95% CI 3.2-177.4), and loss of !3 CVC sites (p ¼ 0.0003, OR 33.3,).There was 98% probability of needing IT when two of these new criteria were present. The 2001 IT criteria have limited predictive ability in the current era and should be revised. A multicenter study is required to validate the findings of this single center experience.

show abstract

Ultrashort Bowel Syndrome in Children

Cited by 27 publications

References 30 publications

Long‐Term Outcome of Home Parenteral Nutrition in Patients With Ultra‐Short Bowel Syndrome

Long‐Term Outcome of Home Parenteral Nutrition in Patients With Ultra‐Short Bowel Syndrome

Nutritional therapy complications in children with ultra‐short bowel syndrome include growth deficiency but not cholestasis

Pediatric Intestinal Transplant Listing Criteria – A Call for a Change in the New Era of Intestinal Failure Outcomes

Contact Info

Product

Resources

About