Ultrasmall Au nanoclusters for biomedical and biosensing applications: A mini-review

Zhang, Yong; Zhang, Chunyu; Chen, Xu; Wang, Xiaolin; Liu, Chang; Waterhouse, Geoffrey I. N.; Wang, Yaling; Yin, Huiming

doi:10.1016/j.talanta.2019.03.068

Cited by 129 publications

(81 citation statements)

References 84 publications

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“…[ 227 ] Gold nanoparticles and nanoclusters also exhibit in vivo toxicity by decreasing red blood cell count and damaging organs such as the spleen, liver and kidney. [ 228 ] Thorough investigations on biosafety will increase public acceptance of products created with nanotechnology. A recent study successfully demonstrated that decreasing the size of gold nanoparticles to the nanocluster range (< 2 nm in diameter) results in enhanced antimicrobial activity against Gram‐positive and Gram‐negative bacteria by increasing intracellular ROS levels but without exerting additional cytotoxic and genotoxic burdens on the host cells.…”

Section: Metal‐based Nanocompoundsmentioning

confidence: 99%

Metal‐Based Nanomaterials in Biomedical Applications: Antimicrobial Activity and Cytotoxicity Aspects

Makvandi

Wang

Zare

et al. 2020

Adv Funct Materials

516

368

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Microbial colonization on material surfaces is ubiquitous. Biofilms derived from surface-colonized microbes pose serious problems to the society from both an economical perspective and a health concern. Incorporation of antimicrobial nanocompounds within or on the surface of materials, or by coatings, to prevent microbial adhesion or kill the microorganisms after their attachment to biofilms, represents an important strategy in an increasingly challenging field. Over the last decade, many studies have been devoted to preparing meta-based nanomaterials that possess antibacterial, antiviral, and antifungal activities to combat pathogen-related diseases. Herein, an overview on the state-of-the-art antimicrobial nanosized metal-based compounds is provided, including metal and metal oxide nanoparticles as well as transition metal nanosheets. The antimicrobial mechanism of these nanostructures and their biomedical applications such as catheters, implants, medical delivery systems, tissue engineering, and dentistry are discussed. Their properties as well as potential caveats such as cytotoxicity, diminishing efficacy, and induction of antimicrobial resistance of materials incorporating these nanostructures are reviewed to provide a backdrop for future research.

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Section: Metal‐based Nanocompoundsmentioning

confidence: 99%

Metal‐Based Nanomaterials in Biomedical Applications: Antimicrobial Activity and Cytotoxicity Aspects

Makvandi

Wang

Zare

et al. 2020

Adv Funct Materials

516

368

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show abstract

“…In noble metal systems, such as gold, these are labelled protoplasmonic. Their properties change from a quantum regime to a size-scaling regime and may offer a number of unique properties, such as permeability in biological systems 1,2 or higher catalytic activity. 3,4 While LAL has been intensively investigated 5 and up-scaling routines have been defined, 6 the tendency is to add a second process to reduce sizes and achieve a well-defined size definition by laser-induced fragmentation in liquids (LFL).…”

mentioning

confidence: 99%

In situstructural kinetics of picosecond laser-induced heating and fragmentation of colloidal gold spheres

Ziefuß

Reich

Reichenberger

et al. 2020

Phys. Chem. Chem. Phys.

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“…As an alternative to organic dyes and QDots, M NCs have a crowd of strike features like ultrasmall size, water solubility, high fluorescent efficiency, large Stokes shifts, excellent photostability, and low cytotoxicity [182], making them become the safe and nontoxic clinical fluorescent contrast agents. In comparison to well-studied Au and Ag NCs [31,[183][184][185], relatively little research investigated the bioimaging application of fluorescent Pt NCs. In general, the imaging way of Pt NCs can be divided into two parts: (1) direct labelling without any other materials and (2) combination of certain biomolecule (e.g., proteins and DNA) to targeted imaging.…”

Section: Biological Applications Of Platinum Nanoclustersmentioning

confidence: 99%

“…This unique electronic properties of M NCs are potently depended on their size, morphology, metal oxidation state, and surrounding ligands [22,23]. Thus, a plenty of efforts focused on the preparation of desired and versatile M NCs by precise control of their sizes or shapes through meticulously choosing stabilized ligands or templates and the usage of NCs in an optical device [24,25], chemical detection [26][27][28][29], catalytic conversion [30], and especially in biological applications [31].…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in the Synthesis, Properties, and Biological Applications of Platinum Nanoclusters

Huang

et al. 2019

Journal of Nanomaterials

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Noble metal nanoclusters (M NCs), defined as an aggregation of a few to tens of atoms, are considered a borderline between atoms and metal nanoparticles (M NPs), which tends to exhibit molecule-like behaviours such as discrete electronic state and size-dependent fluorescence. In the past decades, gold and silver nanoclusters (Au NCs and Ag NCs) have been massively explored and utilized in the field of industrial catalysis, optoelectronic devices, biological imaging, environmental detection, clinical diagnoses, and treatment. The analogue of Au and Ag NCs and platinum nanoclusters (Pt NCs), especially their biological applications, is relatively and rarely discussed. This review firstly investigates the synthetic methodology of Pt NCs including template-assisted and template-free approaches and then introduces their unique optical, catalytic, and thermal properties. Particular importance here is the biological applications of Pt NCs such as the bioimaging of various cells as a preferred fluorophore in contrast to traditional fluorescent markers (e.g., organic dye, semiconductor quantum dots, and fluorescent proteins), the usage of Pt NCs-based antitumour drugs as a new class chemotherapeutics for malignant tumour therapy, and the utilization of antibacteria as an alternative of Ag-based antibacterial agent. On the whole, the development of Pt NCs has already gained delectable progress; however, the study of ultrafine Pt NCs is at the beginning stage and there are still plenty of challenges like synthesis of near-infrared (NIR) fluorescent Pt NCs, the explicit signal pathway of cell apoptosis, and attempt in diverse biological applications that need to be urgently tackled in future.

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Ultrasmall Au nanoclusters for biomedical and biosensing applications: A mini-review

Cited by 129 publications

References 84 publications

Metal‐Based Nanomaterials in Biomedical Applications: Antimicrobial Activity and Cytotoxicity Aspects

Metal‐Based Nanomaterials in Biomedical Applications: Antimicrobial Activity and Cytotoxicity Aspects

In situstructural kinetics of picosecond laser-induced heating and fragmentation of colloidal gold spheres

Recent Advances in the Synthesis, Properties, and Biological Applications of Platinum Nanoclusters

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